Results 31 to 40 of about 11,557,555 (285)

Transient receptor potential channels and calcium dysregulation: a pathogenic duo in Parkinson's disease. [PDF]

Neural Regen Res
Parkinson’s disease (PD) has a complex and multifactorial pathophysiology. Various studies, conducted both in pre-clinical models and PD patients, have reported a link between the disruption of calcium (Ca2+) homeostasis and the subsequent development of
Saeed I, Ma L.
europepmc   +2 more sources

Transient Receptor Potential Cation Channels in Disease [PDF]

Physiological Reviews, 2007
The transient receptor potential (TRP) superfamily consists of a large number of cation channels that are mostly permeable to both monovalent and divalent cations. The 28 mammalian TRP channels can be subdivided into six main subfamilies: the TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPP (polycystin), TRPML (mucolipin), and the TRPA ...
Nilius, Bernd, Owsianik, Grzegorz, Voets, Thomas, Peters, John A.   +3 more
openaire   +2 more sources

Transient Receptor Potential Canonical Channels in Health and Disease: A 2020 Update [PDF]

, 2021
This 2020 Special Issue “TRPC channels” of Cells was dedicated to commemorating the 25th anniversary of discovery of the Transient Receptor Potential Canonical (TRPC) channel subfamily [...
Alexander G. Obukhov, Sooch, Gagandeep S., Obukhov, Alexander G., Priya R. Kirtley, Kirtley, Priya R., White, Fletcher A., Fletcher A. White, Gagandeep S. Sooch   +7 more
core   +1 more source

Dysfunction of transient receptor potential ion channels as an important pathophysiological mechanism in asthma

Russian Open Medical Journal, 2020
Asthma is a chronic heterogeneous disease characterized by chronic inflammation and bronchial hyperreactivity. Neurogenic inflammation is one of the important causes of hyperreactivity.
Oxana Y. Kytikova, Tatyana P. Novgorodtseva, Yulia K. Denisenko, Marina V. Antonyuk, Tatyana A. Gvozdenko   +4 more
doaj   +1 more source

Transient Receptor Potential Channels in Vascular Mechanotransduction. [PDF]

Am J Hypertens
Abstract Transmural pressure and shear stress are mechanical forces that profoundly affect the smooth muscle cells (SMCs) comprising the vascular wall and the endothelial cells (ECs) lining the lumen. Pressure and flow are detected by mechanosensors in these cells and translated into appropriate responses to regulate blood pressure ...
Solano AS, Lavanderos B, Metwally E, Earley S.   +3 more
europepmc   +3 more sources

Modulation of Calcium Transients in Cardiomyocytes by Transient Receptor Potential Canonical 6 Channels

Frontiers in Physiology, 2020
Transient receptor potential canonical 6 (TRPC6) channels are non-selective cation channels that are thought to underlie mechano-modulation of calcium signaling in cardiomyocytes.
Azmi A. Ahmad, Azmi A. Ahmad, Molly E. Streiff, Molly E. Streiff, Chris Hunter, Frank B. Sachse, Frank B. Sachse   +6 more
doaj   +1 more source

Transient Receptor Potential Channels and Inflammatory Bowel Disease

Frontiers in Immunology, 2020
The transient receptor potential (TRP) cation channels are present in abundance across the gastrointestinal (GI) tract, serving as detectors for a variety of stimuli and secondary transducers for G-protein coupled receptors.
Yiding Chen, Yiding Chen, Jingxi Mu, Jingxi Mu, Min Zhu, Min Zhu, Arjudeb Mukherjee, Hu Zhang, Hu Zhang   +8 more
doaj   +1 more source

The Effect of Osthole on Transient Receptor Potential Channels: A Possible Alternative Therapy for Atopic Dermatitis. [PDF]

J Inflamm Res
Natalia Karolina Kordulewska, Angelika Król-Grzymała Department of Biochemistry, Faculty of Biology and Biotechnology, University of Warmia and Mazury, Olsztyn, 10-719, PolandCorrespondence: Natalia Karolina Kordulewska, Oczapowskiego 1A, Olsztyn,
Kordulewska NK, Król-Grzymała A.
europepmc   +2 more sources

The role of transient receptor potential channels in metastasis

Biomedicine & Pharmacotherapy, 2023
Metastasis is the hallmark of failed tumor treatment and is typically associated with death due to cancer. Transient receptor potential (TRP) channels affect changes in intracellular calcium concentrations and participate at every stage of metastasis.
Suwen, Bai, Yuan, Wei, Rong, Liu, Yuhua, Chen, Wanling, Ma, Minghua, Wang, Li, Chen, Yumei, Luo, Juan, Du   +8 more
openaire   +2 more sources

Transient Receptor Potential (TRP) Channels in Haematological Malignancies: An Update

Biomolecules, 2021
Transient receptor potential (TRP) channels are improving their importance in different cancers, becoming suitable as promising candidates for precision medicine.
Federica Maggi, Maria Beatrice Morelli, Massimo Nabissi, Oliviero Marinelli, Laura Zeppa, Cristina Aguzzi, Giorgio Santoni, Consuelo Amantini   +7 more
doaj   +1 more source