Transient Receptor Potential Canonical (TRPC) Channels: Then and Now
Cells, 2020 Twenty-five years ago, the first mammalian Transient Receptor Potential Canonical (TRPC) channel was cloned, opening the vast horizon of the TRPC field. Today, we know that there are seven TRPC channels (TRPC1–7).
Xingjuan Chen +4 more
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Temperature activated transient receptor potential ion channels from Antarctic fishes
Open Biology, 2023 Antarctic notothenioid fishes (cryonotothenioids) live in waters that range between −1.86°C and an extreme maximum +4°C. Evidence suggests these fish sense temperature peripherally, but the molecular mechanism of temperature sensation in unknown ...
Julia M. York
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A novel ion channel formed by interaction of TRPML3 with TRPV5. [PDF]
, 2013 TRPML3 and TRPV5 are members of the mucolipin (TRPML) and TRPV subfamilies of transient receptor potential (TRP) cation channels. Based on sequence similarities of the pore forming regions and on structure-function evidence, we hypothesized that the pore
Becker, Lars +14 more
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Transient Receptor Potential Channels in the Vasculature
Physiological Reviews, 2015 The mammalian genome encodes 28 distinct members of the transient receptor potential (TRP) superfamily of cation channels, which exhibit varying degrees of selectivity for different ionic species. Multiple TRP channels are present in all cells and are involved in diverse aspects of cellular function, including sensory perception and signal transduction.
Scott, Earley, Joseph E, Brayden
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Cellular functions of Transient Receptor Potential channels [PDF]
The International Journal of Biochemistry & Cell Biology, 2010 Transient Receptor Potential channels are polymodal cellular sensors involved in a wide variety of cellular processes, mainly by increasing cellular Ca(2+). In this review we focus on the roles of these channels in: (i) cell death (ii) proliferation and differentiation and (iii) transmitter release.
Daniela, Dadon, Baruch, Minke
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Transient receptor potential ion channels control thermoregulatory behaviour in reptiles. [PDF]
PLoS ONE, 2007 Biological functions are governed by thermodynamics, and animals regulate their body temperature to optimise cellular performance and to avoid harmful extremes.
Frank Seebacher, Shauna A Murray
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Ultrasonic neuromodulation mediated by mechanosensitive ion channels: current and future
Frontiers in Neuroscience, 2023 Ultrasound neuromodulation technology is a promising neuromodulation approach, with the advantages of noninvasiveness, high-resolution, deep penetration and good targeting, which aid in circumventing the side effects of drugs and invasive therapeutic ...
Mengyao Song +9 more
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Canonical transient receptor potential channels and hypothalamic control of homeostatic functions [PDF]
Journal of NeuroendocrinologyMartin J Kelly, Edward J Wagner
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TRPing to the Point of Clarity: Understanding the Function of the Complex TRPV4 Ion Channel
Cells, 2021 The transient receptor potential vanilloid 4 channel (TRPV4) belongs to the mammalian TRP superfamily of cation channels. TRPV4 is ubiquitously expressed, activated by a disparate array of stimuli, interacts with a multitude of proteins, and is modulated
Trine L. Toft-Bertelsen, Nanna MacAulay
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Redox Regulation of Transient Receptor Potential Channels [PDF]
Antioxidants & Redox Signaling, 2014 Significance: Environmental and endogenous reactive species such as reactive oxygen species (ROS), reactive nitrogen species (RNS), and other electrophiles are not only known to exert toxic effects on organisms, but are also emerging as molecules that mediate cell ...
Kozai, Daisuke +2 more
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