Results 11 to 20 of about 103,120 (254)

Transient Receptor Potential Channels and Itch. [PDF]

Int J Mol Sci, 2022
Transient Receptor Potential (TRP) channels are multifunctional sensory molecules that are abundant in the skin and are involved in the sensory pathways of itch, pain, and inflammation. In this review article, we explore the complex physiology of different TRP channels, their role in modulating itch sensation, and their contributions to the ...
Mahmoud O, Soares GB, Yosipovitch G.
europepmc   +3 more sources

Transient receptor potential channel polymorphisms are associated with the somatosensory function in neuropathic pain patients. [PDF]

PLoS ONE, 2011
Transient receptor potential channels are important mediators of thermal and mechanical stimuli and play an important role in neuropathic pain. The contribution of hereditary variants in the genes of transient receptor potential channels to neuropathic ...
Andreas Binder, Denisa May, Ralf Baron, Christoph Maier, Thomas R Tölle, Rolf-Detlef Treede, Achim Berthele, Frank Faltraco, Herta Flor, Janne Gierthmühlen, Sierk Haenisch, Volker Huge, Walter Magerl, Christian Maihöfner, Helmut Richter, Roman Rolke, Andrea Scherens, Nurcan Uçeyler, Mike Ufer, Gunnar Wasner, Jihong Zhu, Ingolf Cascorbi   +21 more
doaj   +1 more source

Transient Receptor Potential Cation Channels in Disease [PDF]

Physiological Reviews, 2007
The transient receptor potential (TRP) superfamily consists of a large number of cation channels that are mostly permeable to both monovalent and divalent cations. The 28 mammalian TRP channels can be subdivided into six main subfamilies: the TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPP (polycystin), TRPML (mucolipin), and the TRPA ...
Nilius, Bernd, Owsianik, Grzegorz, Voets, Thomas, Peters, John A.   +3 more
openaire   +2 more sources

Dysfunction of transient receptor potential ion channels as an important pathophysiological mechanism in asthma

Russian Open Medical Journal, 2020
Asthma is a chronic heterogeneous disease characterized by chronic inflammation and bronchial hyperreactivity. Neurogenic inflammation is one of the important causes of hyperreactivity.
Oxana Y. Kytikova, Tatyana P. Novgorodtseva, Yulia K. Denisenko, Marina V. Antonyuk, Tatyana A. Gvozdenko   +4 more
doaj   +1 more source

Modulation of Calcium Transients in Cardiomyocytes by Transient Receptor Potential Canonical 6 Channels

Frontiers in Physiology, 2020
Transient receptor potential canonical 6 (TRPC6) channels are non-selective cation channels that are thought to underlie mechano-modulation of calcium signaling in cardiomyocytes.
Azmi A. Ahmad, Azmi A. Ahmad, Molly E. Streiff, Molly E. Streiff, Chris Hunter, Frank B. Sachse, Frank B. Sachse   +6 more
doaj   +1 more source

Transient Receptor Potential Channels and Inflammatory Bowel Disease

Frontiers in Immunology, 2020
The transient receptor potential (TRP) cation channels are present in abundance across the gastrointestinal (GI) tract, serving as detectors for a variety of stimuli and secondary transducers for G-protein coupled receptors.
Yiding Chen, Yiding Chen, Jingxi Mu, Jingxi Mu, Min Zhu, Min Zhu, Arjudeb Mukherjee, Hu Zhang, Hu Zhang   +8 more
doaj   +1 more source

Transient Receptor Potential (TRP) Channels [PDF]

, 2018
Transient Receptor Potential (TRP) channels are evolutionarily conserved integral membrane proteins. The mammalian TRP superfamily of ion channels consists of 28 cation permeable channels that are grouped into six subfamilies based on sequence homology (Fig. 6.1).
Amrita, Samanta, Taylor E T, Hughes, Vera Y, Moiseenkova-Bell   +2 more
openaire   +2 more sources

Transient Receptor Potential (TRP) Channels in Haematological Malignancies: An Update

Biomolecules, 2021
Transient receptor potential (TRP) channels are improving their importance in different cancers, becoming suitable as promising candidates for precision medicine.
Federica Maggi, Maria Beatrice Morelli, Massimo Nabissi, Oliviero Marinelli, Laura Zeppa, Cristina Aguzzi, Giorgio Santoni, Consuelo Amantini   +7 more
doaj   +1 more source

Transient receptor potential channel TRPV4 mediates TGF-β1-induced differentiation of human ventricular fibroblasts

Cardiology Journal, 2020
BACKGROUND: Cardiac fibroblasts (CFs) are principal extracellular matrix-producing cells. In response to injury, CFs transdifferentiate into myofibroblasts. Intracellular calcium (Ca2+) signaling, involved in fibroblast proliferation and differentiation,
Min-Soo Ahn, Young Woo Eom, Ji-Eun Oh, Seung-Kuy Cha, Kyu Sang Park, Jung-Woo Son, Jun-Won Lee, Young Jin Youn, Sung Gyun Ahn, Jang-Young Kim, Seung-Hwan Lee, Junghan Yoon, Byung-Su Yoo   +12 more
doaj   +1 more source

Transient Receptor Potential Canonical (TRPC) Channels: Then and Now

Cells, 2020
Twenty-five years ago, the first mammalian Transient Receptor Potential Canonical (TRPC) channel was cloned, opening the vast horizon of the TRPC field. Today, we know that there are seven TRPC channels (TRPC1–7).
Xingjuan Chen, Gagandeep Sooch, Isaac S. Demaree, Fletcher A. White, Alexander G. Obukhov   +4 more
doaj   +1 more source