Results 11 to 20 of about 108,113 (287)

Transient Receptor Potential Channels and Itch. [PDF]

Int J Mol Sci, 2022
Transient Receptor Potential (TRP) channels are multifunctional sensory molecules that are abundant in the skin and are involved in the sensory pathways of itch, pain, and inflammation. In this review article, we explore the complex physiology of different TRP channels, their role in modulating itch sensation, and their contributions to the ...
Mahmoud O, Soares GB, Yosipovitch G.
europepmc   +4 more sources

Transient receptor potential channel polymorphisms are associated with the somatosensory function in neuropathic pain patients. [PDF]

PLoS ONE, 2011
Transient receptor potential channels are important mediators of thermal and mechanical stimuli and play an important role in neuropathic pain. The contribution of hereditary variants in the genes of transient receptor potential channels to neuropathic ...
Andreas Binder, Denisa May, Ralf Baron, Christoph Maier, Thomas R Tölle, Rolf-Detlef Treede, Achim Berthele, Frank Faltraco, Herta Flor, Janne Gierthmühlen, Sierk Haenisch, Volker Huge, Walter Magerl, Christian Maihöfner, Helmut Richter, Roman Rolke, Andrea Scherens, Nurcan Uçeyler, Mike Ufer, Gunnar Wasner, Jihong Zhu, Ingolf Cascorbi   +21 more
doaj   +3 more sources

Transient Receptor Potential Cation Channels in Disease [PDF]

Physiological Reviews, 2007
The transient receptor potential (TRP) superfamily consists of a large number of cation channels that are mostly permeable to both monovalent and divalent cations. The 28 mammalian TRP channels can be subdivided into six main subfamilies: the TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPP (polycystin), TRPML (mucolipin), and the TRPA ...
Nilius, Bernd, Owsianik, Grzegorz, Voets, Thomas, Peters, John A.   +3 more
openaire   +4 more sources

Transient Receptor Potential Channels and Calcium Signaling [PDF]

Cold Spring Harbor Perspectives in Biology, 2019
Transient receptor potential (TRP) cation channels play diverse roles in cellular Ca2+ signaling. First, as Ca2+-permeable channels that respond to a variety of stimuli, TRP channels can directly initiate cellular Ca2+ signals. Second, as nonselective cation channels, TRP channel activation leads to membrane depolarization, influencing Ca2+ influx via ...
Vangeel, Laura, Voets, Thomas
openaire   +4 more sources

Transient receptor potential channels in Alzheimer's disease

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2007
Cognitive impairment and emotional disturbances in Alzheimer's disease (AD) result from the degeneration of synapses and neuronal death in the limbic system and associated regions of the cerebral cortex. An alteration in the proteolytic processing of the amyloid precursor protein (APP) results in increased production and accumulation of amyloid beta ...
Yamamoto, Shinichiro, Wajima, Teruaki, Hara, Yuji, Nishida, Motohiro, Mori, Yasuo   +4 more
openaire   +3 more sources

Transient Receptor Potential Channels and Dermatological Disorders

Current Topics in Medicinal Chemistry, 2013
Transient receptor potential (TRP) cation channels are an emerging field of research in dermatology. Beyond their classical role in skin sensory perception, TRPs are involved in various cutaneous functions that include keratinocyte differentiation, apoptosis and melanocyte pigmentation.
Rodrigo, Valdes-Rodriguez, Shivani B, Kaushik, Gil, Yosipovitch   +2 more
openaire   +3 more sources

Transient Receptor Potential (TRP) Channels: Markers and Therapeutic Targets for Cancer? [PDF]

Biomolecules, 2022
This Special Issue in Biomolecules explores the roles of Transient Receptor Potential channels (TRPs) in cancer [...]
Maria Beatrice Morelli, Consuelo Amantini   +1 more
doaj   +2 more sources

A novel method for evaluating activity of transient receptor potential channels using a cellular dielectric spectroscopy

Journal of Pharmacological Sciences, 2020
Cellular dielectric spectroscopy (CDS) is a novel technology enabling pharmacological evaluation of multiple receptor types with a label-free cell-based assay.
Kanako Miyano, Katsuya Ohbuchi, Yuka Sudo, Kouichiro Minami, Toru Yokoyama, Masahiro Yamamoto, Miaki Uzu, Miki Nonaka, Seiji Shiraishi, Hiroaki Murata, Yoshikazu Higami, Yasuhito Uezono   +11 more
doaj   +2 more sources

Vanilloid Transient Receptor Potential Cation Channels: An Overview [PDF]

Current Pharmaceutical Design, 2008
The mammalian branch of the Transient Receptor Potential (TRP) superfamily of cation channels consists of 28 members. They can be subdivided in six main subfamilies: the TRPC ('Canonical'), TRPV ('Vanilloid'), TRPM ('Melastatin'), TRPP ('Polycystin'), TRPML ('Mucolipin') and the TRPA ('Ankyrin') group.
Vennekens, Rudi, Owsianik, Grzegorz, Nilius, Bernd   +2 more
openaire   +5 more sources

Transient Receptor Potential Channels, the Kidney and Hypertension

Current Hypertension Reviews, 2006
Smooth muscle cells as well as non-excitable cells express multiple cationic channels with significant permeability to calcium, potassium and sodium. Several of these channels are sensors of calcium store depletion, G-protein coupled receptor activation, membrane stretch, intracellular Ca2+, pH, oxidative stress, phospholipid signals and other factors.
MENE', Paolo
openaire   +2 more sources