Results 21 to 30 of about 108,113 (287)

Transient receptor potential channels and calcium dysregulation: a pathogenic duo in Parkinson's disease. [PDF]

Neural Regen Res
Parkinson’s disease (PD) has a complex and multifactorial pathophysiology. Various studies, conducted both in pre-clinical models and PD patients, have reported a link between the disruption of calcium (Ca2+) homeostasis and the subsequent development of
Saeed I, Ma L.
europepmc   +2 more sources

Transient Receptor Potential (TRP) Channels [PDF]

, 2018
Transient Receptor Potential (TRP) channels are evolutionarily conserved integral membrane proteins. The mammalian TRP superfamily of ion channels consists of 28 cation permeable channels that are grouped into six subfamilies based on sequence homology (Fig. 6.1).
Amrita, Samanta, Taylor E T, Hughes, Vera Y, Moiseenkova-Bell   +2 more
openaire   +3 more sources

The Effect of Osthole on Transient Receptor Potential Channels: A Possible Alternative Therapy for Atopic Dermatitis. [PDF]

J Inflamm Res
Natalia Karolina Kordulewska, Angelika Król-Grzymała Department of Biochemistry, Faculty of Biology and Biotechnology, University of Warmia and Mazury, Olsztyn, 10-719, PolandCorrespondence: Natalia Karolina Kordulewska, Oczapowskiego 1A, Olsztyn,
Kordulewska NK, Król-Grzymała A.
europepmc   +2 more sources

Dysfunction of transient receptor potential ion channels as an important pathophysiological mechanism in asthma

Russian Open Medical Journal, 2020
Asthma is a chronic heterogeneous disease characterized by chronic inflammation and bronchial hyperreactivity. Neurogenic inflammation is one of the important causes of hyperreactivity.
Oxana Y. Kytikova, Tatyana P. Novgorodtseva, Yulia K. Denisenko, Marina V. Antonyuk, Tatyana A. Gvozdenko   +4 more
doaj   +1 more source

Modulation of Calcium Transients in Cardiomyocytes by Transient Receptor Potential Canonical 6 Channels

Frontiers in Physiology, 2020
Transient receptor potential canonical 6 (TRPC6) channels are non-selective cation channels that are thought to underlie mechano-modulation of calcium signaling in cardiomyocytes.
Azmi A. Ahmad, Azmi A. Ahmad, Molly E. Streiff, Molly E. Streiff, Chris Hunter, Frank B. Sachse, Frank B. Sachse   +6 more
doaj   +1 more source

Transient Receptor Potential Channels and Inflammatory Bowel Disease

Frontiers in Immunology, 2020
The transient receptor potential (TRP) cation channels are present in abundance across the gastrointestinal (GI) tract, serving as detectors for a variety of stimuli and secondary transducers for G-protein coupled receptors.
Yiding Chen, Yiding Chen, Jingxi Mu, Jingxi Mu, Min Zhu, Min Zhu, Arjudeb Mukherjee, Hu Zhang, Hu Zhang   +8 more
doaj   +1 more source

Transient Receptor Potential (TRP) Channels in Haematological Malignancies: An Update

Biomolecules, 2021
Transient receptor potential (TRP) channels are improving their importance in different cancers, becoming suitable as promising candidates for precision medicine.
Federica Maggi, Maria Beatrice Morelli, Massimo Nabissi, Oliviero Marinelli, Laura Zeppa, Cristina Aguzzi, Giorgio Santoni, Consuelo Amantini   +7 more
doaj   +1 more source

Transient Receptor Potential Channels and Auditory Functions. [PDF]

Antioxid Redox Signal, 2022
Significance: Transient receptor potential (TRP) channels are cation-gated channels that serve as detectors of various sensory modalities, such as pain, heat, cold, and taste. These channels are expressed in the inner ear, suggesting that they could also contribute to the perception of sound.
Ramkumar V, Sheth S, Dhukhwa A, Al Aameri R, Rybak L, Mukherjea D.   +5 more
europepmc   +3 more sources

Transient receptor potential channel TRPV4 mediates TGF-β1-induced differentiation of human ventricular fibroblasts

Cardiology Journal, 2020
BACKGROUND: Cardiac fibroblasts (CFs) are principal extracellular matrix-producing cells. In response to injury, CFs transdifferentiate into myofibroblasts. Intracellular calcium (Ca2+) signaling, involved in fibroblast proliferation and differentiation,
Min-Soo Ahn, Young Woo Eom, Ji-Eun Oh, Seung-Kuy Cha, Kyu Sang Park, Jung-Woo Son, Jun-Won Lee, Young Jin Youn, Sung Gyun Ahn, Jang-Young Kim, Seung-Hwan Lee, Junghan Yoon, Byung-Su Yoo   +12 more
doaj   +1 more source

The transient receptor potential family of ion channels [PDF]

Genome Biology, 2011
The transient receptor potential (TRP) multigene superfamily encodes integral membrane proteins that function as ion channels. Members of this family are conserved in yeast, invertebrates and vertebrates. The TRP family is subdivided into seven subfamilies: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPP (polycystin), TRPML (mucolipin ...
Nilius, Bernd, Owsianik, Grzegorz
openaire   +2 more sources