Results 21 to 30 of about 103,120 (254)
Temperature activated transient receptor potential ion channels from Antarctic fishes
Open Biology, 2023 Antarctic notothenioid fishes (cryonotothenioids) live in waters that range between −1.86°C and an extreme maximum +4°C. Evidence suggests these fish sense temperature peripherally, but the molecular mechanism of temperature sensation in unknown ...
Julia M. York
doaj +1 more source
Transient Receptor Potential Channels and Auditory Functions. [PDF]
Antioxid Redox Signal, 2022 Significance: Transient receptor potential (TRP) channels are cation-gated channels that serve as detectors of various sensory modalities, such as pain, heat, cold, and taste. These channels are expressed in the inner ear, suggesting that they could also contribute to the perception of sound.
Ramkumar V +5 more
europepmc +3 more sources
Transient Receptor Potential Channels in the Vasculature
Physiological Reviews, 2015 The mammalian genome encodes 28 distinct members of the transient receptor potential (TRP) superfamily of cation channels, which exhibit varying degrees of selectivity for different ionic species. Multiple TRP channels are present in all cells and are involved in diverse aspects of cellular function, including sensory perception and signal transduction.
Scott, Earley, Joseph E, Brayden
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Transient receptor potential ion channels control thermoregulatory behaviour in reptiles. [PDF]
PLoS ONE, 2007 Biological functions are governed by thermodynamics, and animals regulate their body temperature to optimise cellular performance and to avoid harmful extremes.
Frank Seebacher, Shauna A Murray
doaj +1 more source
Transient Receptor Potential Channels and Calcium Signaling [PDF]
Cold Spring Harbor Perspectives in Biology, 2019 Transient receptor potential (TRP) cation channels play diverse roles in cellular Ca2+ signaling. First, as Ca2+-permeable channels that respond to a variety of stimuli, TRP channels can directly initiate cellular Ca2+ signals. Second, as nonselective cation channels, TRP channel activation leads to membrane depolarization, influencing Ca2+ influx via ...
Vangeel, Laura, Voets, Thomas
openaire +3 more sources
Ultrasonic neuromodulation mediated by mechanosensitive ion channels: current and future
Frontiers in Neuroscience, 2023 Ultrasound neuromodulation technology is a promising neuromodulation approach, with the advantages of noninvasiveness, high-resolution, deep penetration and good targeting, which aid in circumventing the side effects of drugs and invasive therapeutic ...
Mengyao Song +9 more
doaj +1 more source
The transient receptor potential family of ion channels [PDF]
Genome Biology, 2011 The transient receptor potential (TRP) multigene superfamily encodes integral membrane proteins that function as ion channels. Members of this family are conserved in yeast, invertebrates and vertebrates. The TRP family is subdivided into seven subfamilies: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPP (polycystin), TRPML (mucolipin ...
Nilius, Bernd, Owsianik, Grzegorz
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TRPing to the Point of Clarity: Understanding the Function of the Complex TRPV4 Ion Channel
Cells, 2021 The transient receptor potential vanilloid 4 channel (TRPV4) belongs to the mammalian TRP superfamily of cation channels. TRPV4 is ubiquitously expressed, activated by a disparate array of stimuli, interacts with a multitude of proteins, and is modulated
Trine L. Toft-Bertelsen, Nanna MacAulay
doaj +1 more source
Canonical transient receptor potential channels and hypothalamic control of homeostatic functions [PDF]
Journal of NeuroendocrinologyMartin Kelly, Ed Wagner
exaly +2 more sources
Transient receptor potential channels in Alzheimer's disease
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2007 Cognitive impairment and emotional disturbances in Alzheimer's disease (AD) result from the degeneration of synapses and neuronal death in the limbic system and associated regions of the cerebral cortex. An alteration in the proteolytic processing of the amyloid precursor protein (APP) results in increased production and accumulation of amyloid beta ...
Yamamoto, Shinichiro +4 more
openaire +2 more sources