Results 51 to 60 of about 10,656,275 (241)

The Transient Receptor Potential Superfamily of Ion Channels [PDF]

Journal of the American Society of Nephrology, 2004
ABSTRACT. The transient receptor potential (TRP) superfamily of proteins is cation-selective ion channels with six predicted transmembrane segments and intracellularly localized amino and carboxyl termini. Members of the TRP superfamily are identified on the basis of amino acid sequence and structural similarity and are classified into TRPC, TRPV, TRPM,
openaire   +2 more sources

Transient receptor potential (TRP) channels: a metabolic TR(i)P to obesity prevention and therapy

, 2018
Cellular transport of ions, especially by ion channels, regulates physiological function. The transient receptor potential (TRP) channels, with 30 identified so far, are cation channels with high calcium permeability.
Bishnoi, M., Panchal, SK, Khare, P., Panchal, Sunil K. (R20071), Khare, Pragyanshu, L. Brown, Panchal, S. K., Brown, Lindsay, M. Bishnoi, P. Khare, Bishnoi, M, S. K. Panchal, Brown, L., Khare, P, Bishnoi, Mahendra, Brown, L   +15 more
core   +1 more source

Modulation and Regulation of Canonical Transient Receptor Potential 3 (TRPC3) Channels

Cells, 2023
Canonical transient receptor potential 3 (TRPC3) channel is a non-selective cation permeable channel that plays an essential role in calcium signalling.
Bethan A. Cole, Esther B. E. Becker
doaj   +1 more source

MAMMALIAN TRANSIENT RECEPTOR POTENTIAL TRPA1 CHANNELS: FROM STRUCTURE TO DISEASE

, 2019
The transient receptor potential ankyrin (TRPA) channels are Ca2+-permeable nonselective cation channels remarkably conserved through the animal kingdom.
Boonen, Brett, Brett Boonen, Yeranddy A. Alpizar, Startek, Justyna B., Alvarez-Collazo, Julio, Alpizar, Yeranddy A., Julio Alvarez-Collazo, Talavera, Karel, Bernd Nilius, Naert, Robbe, Alicia Sanchez, Karel Talavera, Nilius, Bernd, AGUIAR ALPIZAR, Yeranddy, Robbe Naert, Alpizar, Yeranddy A, Justyna B. Startek, Startek, Justyna B, Sanchez, Alicia   +18 more
core   +1 more source

Transient Receptor Potential Canonical (TRPC) Channels as Modulators of Migration and Invasion [PDF]

, 2020
Calcium (Ca2+) is perhaps the most versatile signaling molecule in cells. Ca2+ regulates a large number of key events in cells, ranging from gene transcription, motility, and contraction, to energy production and channel gating.
Törnquist, Kid, Asghar, Muhammad Yasir, Kid Törnquist, Muhammad Yasir Asghar   +3 more
core   +1 more source

Canonical transient receptor potential channels in diabetes [PDF]

Experimental Biology and Medicine, 2012
Canonical transient receptor potential (TRPC) channel proteins have been identified as downstream molecules in a G protein-coupled receptor signaling pathway and are involved in a variety of cell functions due to their ability to regulate intracellular calcium signaling.
Sarabeth, Graham, Joseph P, Yuan, Rong, Ma   +2 more
openaire   +2 more sources

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

A novel method for evaluating activity of transient receptor potential channels using a cellular dielectric spectroscopy

Journal of Pharmacological Sciences, 2020
Cellular dielectric spectroscopy (CDS) is a novel technology enabling pharmacological evaluation of multiple receptor types with a label-free cell-based assay.
Kanako Miyano, Katsuya Ohbuchi, Yuka Sudo, Kouichiro Minami, Toru Yokoyama, Masahiro Yamamoto, Miaki Uzu, Miki Nonaka, Seiji Shiraishi, Hiroaki Murata, Yoshikazu Higami, Yasuhito Uezono   +11 more
doaj   +1 more source

TRPC1 channels underlie stretch-modulated sarcoplasmic reticulum calcium leak in cardiomyocytes

Frontiers in Physiology, 2022
Transient receptor potential canonical 1 (TRPC1) channels are Ca2+-permeable ion channels expressed in cardiomyocytes. An involvement of TRPC1 channels in cardiac diseases is widely established.
Molly E. Streiff, Molly E. Streiff, Andrea C. Corbin, Andrea C. Corbin, Azmi A. Ahmad, Azmi A. Ahmad, Chris Hunter, Frank B. Sachse, Frank B. Sachse   +8 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source