Results 51 to 60 of about 108,113 (287)
TRP Channels as Molecular Targets to Relieve Endocrine-Related Diseases
Frontiers in Molecular Biosciences, 2022 Transient receptor potential (TRP) channels are polymodal channels capable of sensing environmental stimuli, which are widely expressed on the plasma membrane of cells and play an essential role in the physiological or pathological processes of cells as ...
Yusheng Liu, Yihan Lyu, Hongmei Wang
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Transient Receptor Potential Channels and Metabolism.
Molecules and cells, 2019 Transient receptor potential (TRP) channels are nonselective cationic channels, conserved among flies to humans. Most TRP channels have well known functions in chemosensation, thermosensation, and mechanosensation. In addition to being sensing environmental changes, many TRP channels are also internal sensors that help maintain homeostasis.
Dhakal, Subash, Lee, Youngseok
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Transient Receptor Potential Canonical (TRPC) Channels as Modulators of Migration and Invasion [PDF]
, 2020 Calcium (Ca2+) is perhaps the most versatile signaling molecule in cells. Ca2+ regulates a large number of key events in cells, ranging from gene transcription, motility, and contraction, to energy production and channel gating.
Törnquist, Kid +3 more
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Frontiers in Physiology, 2022 Lipids modulate the function of many ion channels, possibly through direct lipid-protein interactions. The recent outpouring of ion channel structures by cryo-EM has revealed many lipid binding sites.
Wayland W. L. Cheng +2 more
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Canonical transient receptor potential channels in diabetes [PDF]
Experimental Biology and Medicine, 2012 Canonical transient receptor potential (TRPC) channel proteins have been identified as downstream molecules in a G protein-coupled receptor signaling pathway and are involved in a variety of cell functions due to their ability to regulate intracellular calcium signaling.
Sarabeth, Graham +2 more
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The Transient Receptor Potential Superfamily of Ion Channels [PDF]
Journal of the American Society of Nephrology, 2004 ABSTRACT. The transient receptor potential (TRP) superfamily of proteins is cation-selective ion channels with six predicted transmembrane segments and intracellularly localized amino and carboxyl termini. Members of the TRP superfamily are identified on the basis of amino acid sequence and structural similarity and are classified into TRPC, TRPV, TRPM,
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TRPC1 channels underlie stretch-modulated sarcoplasmic reticulum calcium leak in cardiomyocytes
Frontiers in Physiology, 2022 Transient receptor potential canonical 1 (TRPC1) channels are Ca2+-permeable ion channels expressed in cardiomyocytes. An involvement of TRPC1 channels in cardiac diseases is widely established.
Molly E. Streiff +8 more
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, 2009 We investigate activation mechanisms of native TRPC1/C5/C6 channels (termed TRPC1 channels) by stimulation of endothelin-1 (ET-1) receptor subtypes in freshly dispersed rabbit coronary artery myocytes using single channel recording and ...
Anthony P. Albert +8 more
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Transient receptor potential (TRP) channels: a metabolic TR(i)P to obesity prevention and therapy
, 2018 Cellular transport of ions, especially by ion channels, regulates physiological function. The transient receptor potential (TRP) channels, with 30 identified so far, are cation channels with high calcium permeability.
Bishnoi, M. +15 more
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Drosophila TRPM channel is essential for the control of extracellular magnesium levels [PDF]
, 2010 The TRPM group of cation channels plays diverse roles ranging from sensory signaling to Mg2+ homeostasis. In most metazoan organisms the TRPM subfamily is comprised of multiple members, including eight in humans. However, the Drosophila TRPM subfamily is
Vladimir Chubanov +18 more
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