Transient receptor potential channel polymorphisms are associated with the somatosensory function in neuropathic pain patients. [PDF]
PLoS ONE, 2011 Transient receptor potential channels are important mediators of thermal and mechanical stimuli and play an important role in neuropathic pain. The contribution of hereditary variants in the genes of transient receptor potential channels to neuropathic ...
Andreas Binder +21 more
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Porcine transient receptor potential channel 1 promotes adipogenesis and lipid deposition [PDF]
Journal of Lipid ResearchAdipose tissue, an important organ involved in energy metabolism and endocrine, is closely related to animal meat quality and human health. Transient receptor potential channel 1 (TRPC1), an ion transporter, is adipocytes’ major Ca2+ entry channel ...
Yu Fu +7 more
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Peripheral glutamate receptor and transient receptor potential channel mechanisms of craniofacial muscle pain [PDF]
Molecular Pain, 2020 Temporomandibular joint disorder is a common chronic craniofacial pain condition, often involving persistent, widespread craniofacial muscle pain.
Man-Kyo Chung, Jin Y Ro
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Transient Receptor Potential Channel Ankyrin 1: A Unique Regulator of Vascular Function [PDF]
Cells, 2021 TRPA1 (transient receptor potential ankyrin 1), the lone member of the mammalian ankyrin TRP subfamily, is a Ca2+-permeable, non-selective cation channel.
Michael G. Alvarado +2 more
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Transient Receptor Potential Channel 4 Small-Molecule Inhibition Alleviates Migraine-Like Behavior in Mice [PDF]
Frontiers in Molecular Neuroscience, 2021 Migraine is a common neurological disorder with few available treatment options. Recently, we have demonstrated the role of transient receptor potential cation channel subfamily C member 4 (TRPC4) in itch and the modulation of the calcitonin gene-related
Cinder Faith Cohen +5 more
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Transient receptor potential channel TRPV4 mediates TGF-β1-induced differentiation of human ventricular fibroblasts [PDF]
Cardiology Journal, 2020 BACKGROUND: Cardiac fibroblasts (CFs) are principal extracellular matrix-producing cells. In response to injury, CFs transdifferentiate into myofibroblasts. Intracellular calcium (Ca2+) signaling, involved in fibroblast proliferation and differentiation,
Min-Soo Ahn +12 more
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Role of transient receptor potential melastatin type 7 channel in gastric cancer
Integrative Medicine Research, 2016 Transient receptor potential (TRP) proteins are a family of ion channels, which are responsible for a wide array of cellular functions. In particular, TRP melastatin type (TRPM) 7 is expressed everywhere and permeable to divalent cations such as Mg2+ and
Byung Joo Kim, Chansik Hong
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Anti-Inflammatory Effects of Serotonin Receptor and Transient Receptor Potential Channel Ligands in Human Small Intestinal Epithelial Cells [PDF]
Current Issues in Molecular Biology, 2023 Bo Wang +2 more
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Mouse transient receptor potential channel type 6 selectively regulates agonist-induced platelet function [PDF]
Biochemistry and Biophysics Reports, 2019 While changes in intracellular calcium levels is a central step in platelet activation and thrombus formation, the contribution and mechanism of receptor-operated calcium entry (ROCE) via transient receptor potential channels (TRPCs) in platelets remains
Enma V. Paez Espinosa +4 more
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mSphere, 2023 Transient receptor potential (TRP) channels are evolutionarily conserved integral membrane proteins. They serve as crucial mediators of sensory signals and have profound effects on cellular functions.
Hongchen Wang +3 more
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