Results 1 to 10 of about 11,016,750 (197)

Transient receptor potential channel polymorphisms are associated with the somatosensory function in neuropathic pain patients. [PDF]

PLoS ONE, 2011
Transient receptor potential channels are important mediators of thermal and mechanical stimuli and play an important role in neuropathic pain. The contribution of hereditary variants in the genes of transient receptor potential channels to neuropathic ...
Andreas Binder, Denisa May, Ralf Baron, Christoph Maier, Thomas R Tölle, Rolf-Detlef Treede, Achim Berthele, Frank Faltraco, Herta Flor, Janne Gierthmühlen, Sierk Haenisch, Volker Huge, Walter Magerl, Christian Maihöfner, Helmut Richter, Roman Rolke, Andrea Scherens, Nurcan Uçeyler, Mike Ufer, Gunnar Wasner, Jihong Zhu, Ingolf Cascorbi   +21 more
doaj   +6 more sources

Classical Transient Receptor Potential 1 (TRPC1): Channel or Channel Regulator? [PDF]

Cells, 2014
In contrast to other Classical Transient Receptor Potential TRPC channels the function of TRPC1 as an ion channel is a matter of debate, because it is often difficult to obtain substantial functional signals over background in response to over-expression
Alexander Dietrich, Meike Fahlbusch, Thomas Gudermann   +2 more
doaj   +2 more sources

Role of transient receptor potential melastatin type 7 channel in gastric cancer

Integrative Medicine Research, 2016
Transient receptor potential (TRP) proteins are a family of ion channels, which are responsible for a wide array of cellular functions. In particular, TRP melastatin type (TRPM) 7 is expressed everywhere and permeable to divalent cations such as Mg2+ and
Byung Joo Kim, Chansik Hong
doaj   +3 more sources

Anàlisi genètica i funcional de la migranya hemiplègica i la migranya comuna [PDF]

, 2011
[cat] Aquesta tesi es centra en la genètica de la migranya. La migranya comuna és un trastorn neurològic caracteritzat per episodis recurrents de mal de cap.
Carreño, Oriel
core   +6 more sources

The versatility of the putative transient receptor potential ion channels in regulating the calcium signaling in Aspergillus nidulans

mSphere, 2023
Transient receptor potential (TRP) channels are evolutionarily conserved integral membrane proteins. They serve as crucial mediators of sensory signals and have profound effects on cellular functions.
Hongchen Wang, Renwei Gao, Yuanwei Zhang, Ling Lu   +3 more
doaj   +1 more source

The distinctive role of menthol in pain and analgesia: Mechanisms, practices, and advances

Frontiers in Molecular Neuroscience, 2022
Menthol is an important flavoring additive that triggers a cooling sensation. Under physiological condition, low to moderate concentrations of menthol activate transient receptor potential cation channel subfamily M member 8 (TRPM8) in the primary ...
Ziping Li, Haoyue Zhang, Haoyue Zhang, Yigang Wang, Yigang Wang, Yize Li, Qing Li, Linlin Zhang   +7 more
doaj   +1 more source

Targeting ROS-sensitive TRP ion channels for relieving oxidative stress-related diseases based on nanomaterials

Materials Today Advances, 2023
Reactive oxygen species (ROS) play an important role in regulating various physiological functions by activating specific ion channels to mediate cell growth, proliferation, regeneration, and apoptosis.
Boying Li, Ning Li, Nana Wang, Chaoqun Li, Xiaoning Liu, Zhanshuo Cao, Chengfen Xing, Shu Wang   +7 more
doaj   +1 more source

A novel strategy for treating cancer: understanding the role of Ca2+ signaling from nociceptive TRP channels in regulating cancer progression

Exploration of Targeted Anti-tumor Therapy, 2021
Cancer is an aging-associated disease and caused by genomic instability that is driven by the accumulation of mutations and epimutations in the aging process.
Wen-Li Hsu, Mami Noda, Tohru Yoshioka, Etsuro Ito   +3 more
doaj   +1 more source

Thermo-sensitive TRP channels and prevention of major chronic diseases

Di-san junyi daxue xuebao, 2022
American scientists David Julius and Ardem Patapoutian won the Nobel Prize in physiology or medicine in 2021 for their groundbreaking discoveries of capsaicin receptor TRPV1 and menthol receptor TRPM8, revealing the secrets of temperature perception. The
ZHU Zhiming, LIU Daoyan
doaj   +1 more source

Emerging role of transient receptor potential (TRP) ion channels in cardiac fibroblast pathophysiology

Frontiers in Physiology, 2022
Cardiac fibroblasts make up a major proportion of non-excitable cells in the heart and contribute to the cardiac structural integrity and maintenance of the extracellular matrix.
Asfree Gwanyanya, Kanigula Mubagwa, Kanigula Mubagwa   +2 more
doaj   +1 more source