Results 21 to 30 of about 11,016,750 (197)

The TRPA1 Channel in the Cardiovascular System: Promising Features and Challenges

Frontiers in Pharmacology, 2019
The transient receptor potential ankyrin 1 (TRPA1) channel is a calcium-permeable nonselective cation channel in the plasma membrane that belongs to the transient receptor potential (TRP) channel superfamily.
Zhen Wang, Zhen Wang, Zhen Wang, Di Ye, Di Ye, Di Ye, Jing Ye, Jing Ye, Jing Ye, Menglong Wang, Menglong Wang, Menglong Wang, Jianfang Liu, Jianfang Liu, Jianfang Liu, Huimin Jiang, Huimin Jiang, Huimin Jiang, Yao Xu, Yao Xu, Yao Xu, Jishou Zhang, Jiangbin Chen, Jun Wan, Jun Wan, Jun Wan   +25 more
doaj   +1 more source

Peripheral glutamate receptor and transient receptor potential channel mechanisms of craniofacial muscle pain

Molecular Pain, 2020
Temporomandibular joint disorder is a common chronic craniofacial pain condition, often involving persistent, widespread craniofacial muscle pain.
Man-Kyo Chung, Jin Y Ro
doaj   +1 more source

Transient receptor potential melastatin 1: a hair cell transduction channel candidate. [PDF]

PLoS ONE, 2013
Sound and head movements are perceived through sensory hair cells in the inner ear. Mounting evidence indicates that this process is initiated by the opening of mechanically sensitive calcium-permeable channels, also referred to as the mechanoelectrical ...
John Gerka-Stuyt, Adrian Au, Neal S Peachey, Kumar N Alagramam   +3 more
doaj   +1 more source

Calcium-Permeable Channels Cooperation for Rheumatoid Arthritis: Therapeutic Opportunities

Biomolecules, 2022
Rheumatoid arthritis is a common autoimmune disease that results from the deposition of antibodies–autoantigens in the joints, leading to long-lasting inflammation.
Hong-Yu Liang, Huan-Xin Yin, Shu-Fang Li, Yong Chen, Ying-Jie Zhao, Wei Hu, Ren-Peng Zhou   +6 more
doaj   +1 more source

Drosophila TRPM channel is essential for the control of extracellular magnesium levels [PDF]

, 2010
The TRPM group of cation channels plays diverse roles ranging from sensory signaling to Mg2+ homeostasis. In most metazoan organisms the TRPM subfamily is comprised of multiple members, including eight in humans. However, the Drosophila TRPM subfamily is
Vladimir Chubanov, Craig Montell, Chen, Xiaodi, Xiaodi Chen, Anna S Dietz, Dietz, Anna S., Anna S. Dietz, Chubanov, Vladimir, Thomas Hofmann, Thomas Gudermann, Chen Xiaodi, Hofmann Thomas, Chubanov Vladimir, Dietz Anna S., Montell Craig, Gudermann, Thomas, Gudermann Thomas, Montell, Craig, Hofmann, Thomas   +18 more
core   +2 more sources

Transient Receptor Potential Channels, Natriuretic Peptides, and Angiotensin Receptor-Neprilysin Inhibitors in Patients With Heart Failure

Frontiers in Cardiovascular Medicine, 2022
Heart failure (HF) remains the leading cause of death, morbidity, and medical expenses worldwide. Treatments for HF with reduced ejection fraction have progressed in recent years; however, acute decompensated heart failure remains difficult to treat. The
Kun Ding, Kun Ding, Yang Gui, Yang Gui, Xu Hou, Xu Hou, Lifang Ye, Lihong Wang   +7 more
doaj   +1 more source

Modulation of Transient Receptor Potential C Channel Activity by Cholesterol

Frontiers in Pharmacology, 2019
Changes of cholesterol level in the plasma membrane of cells have been shown to modulate ion channel function. The proposed mechanisms underlying these modulations include association of cholesterol to a single binding site at a single channel ...
Rita Gutorov, Maximilian Peters, Ben Katz, Tal Brandwine, Nicolas A. Barbera, Irena Levitan, Baruch Minke   +6 more
doaj   +1 more source

Responses to transient receptor potential (TRP) channel agonists in Chlamydomonas reinhardtii

Biology Open, 2020
Pungent substances, such as capsaicin and gingerol, activate the transient receptor potential (TRP)-V1 channel and affect the feeding behaviors of animals.
Mamoru Wada, Itaru Kaizuka, Kenjiro Yoshimura   +2 more
doaj   +1 more source

Structural insights into TRPV2 activation by small molecules

Nature Communications, 2022
A non-selective calcium channel transient receptor potential vanilloid 2 (TRPV2) is a potential drug target. Here, the authors employ cryo-electron microscopy, in silico docking, and electrophysiology to identify a binding site for an activator 2 ...
Ruth A. Pumroy, Anna D. Protopopova, Tabea C. Fricke, Iris U. Lange, Ferdinand M. Haug, Phuong T. Nguyen, Pamela N. Gallo, Bárbara B. Sousa, Gonçalo J. L. Bernardes, Vladimir Yarov-Yarovoy, Andreas Leffler, Vera Y. Moiseenkova-Bell   +11 more
doaj   +1 more source

Reduced TRPC channel expression in psoriatic keratinocytes is associated with impaired differentiation and enhanced proliferation [PDF]

, 2011
Psoriasis is a characteristic inflammatory and scaly skin condition with typical histopathological features including increased proliferation and hampered differentiation of keratinocytes.
Ute Woelfle, Kristina Leuner, Schempp, Christoph M., Kraus, Margarethe, Walter E Müller, Harteneck Christian, Christoph M. Schempp, Walter E. Müller, Margarethe Kraus, Harteneck, Christian, Beschmann, Heike, Beschmann, Heike A., Boehncke, Wolf-Henning, Beschmann Heike, Boehncke Wolf-Henning, Schempp Christoph M., Kraus Margarethe, Christoph M Schempp, Schempp, Christoph Mathis, Wolf-Henning Boehncke, Heike Beschmann, Christian Harteneck, Woelfle Ute, Leuner Kristina, Leuner, Kristina, Wölfle, Ute, Müller Walter E., Woelfle, Ute, Müller, Walter E.   +28 more
core   +1 more source