Results 41 to 50 of about 238,661 (303)

Insights into Activation Mechanisms of Store-Operated TRPC1 Channels in Vascular Smooth Muscle. [PDF]

, 2020
In vascular smooth muscle cells (VMSCs), the stimulation of store-operated channels (SOCs) mediate Ca2+ influx pathways which regulate important cellular functions including contraction, proliferation, migration, and growth that are associated with the ...
Albert, AP, Baudel, MASM-A, Large, WA, Shi, J   +3 more
core   +1 more source

Transient Receptor Potential Channels and Calcium Signaling [PDF]

Cold Spring Harbor Perspectives in Biology, 2019
Transient receptor potential (TRP) cation channels play diverse roles in cellular Ca2+ signaling. First, as Ca2+-permeable channels that respond to a variety of stimuli, TRP channels can directly initiate cellular Ca2+ signals. Second, as nonselective cation channels, TRP channel activation leads to membrane depolarization, influencing Ca2+ influx via ...
Vangeel, Laura, Voets, Thomas
openaire   +3 more sources

Enhanced itch elicited by capsaicin in a chronic itch model

Molecular Pain, 2016
Chronic itch (pruritus) is an important clinical problem. However, the underlying molecular basis has yet to be understood. The Transient Receptor Potential Vanilloid 1 channel is a heat-sensitive cation channel expressed in primary sensory neurons and ...
Guang Yu PhD, Niuniu Yang MD, Fengxian Li MD, Meijuan Chen PhD, Changxiong J Guo BS, Changming Wang PhD, Danyou Hu BS, Yan Yang BS, Chan Zhu BS, Zhongli Wang PhD, Hao Shi MD, Tana Gegen MD, Ming Tang MS, Qian He MS, Qin Liu PhD, Zongxiang Tang PhD   +15 more
doaj   +1 more source

The TRPA1 Channel in the Cardiovascular System: Promising Features and Challenges

Frontiers in Pharmacology, 2019
The transient receptor potential ankyrin 1 (TRPA1) channel is a calcium-permeable nonselective cation channel in the plasma membrane that belongs to the transient receptor potential (TRP) channel superfamily.
Zhen Wang, Zhen Wang, Zhen Wang, Di Ye, Di Ye, Di Ye, Jing Ye, Jing Ye, Jing Ye, Menglong Wang, Menglong Wang, Menglong Wang, Jianfang Liu, Jianfang Liu, Jianfang Liu, Huimin Jiang, Huimin Jiang, Huimin Jiang, Yao Xu, Yao Xu, Yao Xu, Jishou Zhang, Jiangbin Chen, Jun Wan, Jun Wan, Jun Wan   +25 more
doaj   +1 more source

Flavaglines Stimulate Transient Receptor Potential Melastatin Type 6 (TRPM6) Channel Activity. [PDF]

PLoS ONE, 2015
Magnesium (Mg2+) is essential for enzymatic activity, brain function and muscle contraction. Blood Mg2+ concentrations are tightly regulated between 0.7 and 1.1 mM by Mg2+ (re)absorption in kidney and intestine.
Maxime G Blanchard, Jeroen H F de Baaij, Sjoerd A J Verkaart, Anke L Lameris, Christine Basmadjian, Qian Zhao, Laurent Désaubry, René J M Bindels, Joost G J Hoenderop   +8 more
doaj   +1 more source

Transient receptor potential melastatin 1: a hair cell transduction channel candidate. [PDF]

PLoS ONE, 2013
Sound and head movements are perceived through sensory hair cells in the inner ear. Mounting evidence indicates that this process is initiated by the opening of mechanically sensitive calcium-permeable channels, also referred to as the mechanoelectrical ...
John Gerka-Stuyt, Adrian Au, Neal S Peachey, Kumar N Alagramam   +3 more
doaj   +1 more source

Transient Receptor Potential Channels, Natriuretic Peptides, and Angiotensin Receptor-Neprilysin Inhibitors in Patients With Heart Failure

Frontiers in Cardiovascular Medicine, 2022
Heart failure (HF) remains the leading cause of death, morbidity, and medical expenses worldwide. Treatments for HF with reduced ejection fraction have progressed in recent years; however, acute decompensated heart failure remains difficult to treat. The
Kun Ding, Kun Ding, Yang Gui, Yang Gui, Xu Hou, Xu Hou, Lifang Ye, Lihong Wang   +7 more
doaj   +1 more source

Identification of a Calcium Signalling Pathway of S-[6]-Gingerol in HuH-7 Cells [PDF]

, 2013
Calcium signals in hepatocytes control cell growth, proliferation, and death. Members of the transient receptor potential (TRP) cation channel superfamily are candidate calcium influx channels. NF?B activation strictly depends on calcium influx and often
Duke, C, Heather, A, Li, X, Li, Y, Mandadi, S, McGrath, K, Roufogalis, B, Tran, V   +7 more
core   +4 more sources

The asparagine 533 residue in the outer pore loop region of the mouse PKD2L1 channel is essential for its voltage‐dependent inactivation

FEBS Open Bio, 2017
Voltage‐dependent inactivation of ion channels contributes to the regulation of the membrane potential of excitable cells. Mouse polycystic kidney disease 2‐like 1 (PKD2L1) forms voltage‐dependent nonselective cation channels, which are activated but ...
Takahiro Shimizu, Taiga Higuchi, Toshihiro Toba, Chie Ohno, Takuto Fujii, Bernd Nilius, Hideki Sakai   +6 more
doaj   +1 more source

Responses to transient receptor potential (TRP) channel agonists in Chlamydomonas reinhardtii

Biology Open, 2020
Pungent substances, such as capsaicin and gingerol, activate the transient receptor potential (TRP)-V1 channel and affect the feeding behaviors of animals.
Mamoru Wada, Itaru Kaizuka, Kenjiro Yoshimura   +2 more
doaj   +1 more source