Results 41 to 50 of about 127,083 (259)

Tetrandrine Suppresses Transient Receptor Potential Cation Channel Protein 6 Overexpression- Induced Podocyte Damage via Blockage of RhoA/ROCK1 Signaling

Drug Design, Development and Therapy, 2020
Jin Yu, Caifeng Zhu, Jiazhen Yin, Dongrong Yu, Feng Wan, Xuanli Tang, Xue Jiang Department of Nephrology, Guangxing Hospital Affiliated to ZheJiang Chinese Medical University (Key Laboratory of Zhejiang Province, Management of Kidney Disease), Hangzhou ...
Yu J, Zhu C, Yin J, Yu D, Wan F, Tang X, Jiang X   +6 more
doaj  

Dynamic evolution of transient receptor potential vanilloid (TRPV) ion channel family with numerous gene duplications and losses

Frontiers in Endocrinology, 2022
The transient receptor potential vanilloid (TRPV) ion channel family is involved in multiple sensory and physiological functions including thermosensing and temperature-dependent neuroendocrine regulation.
Marina Morini, Marina Morini, Christina A. Bergqvist, Juan F. Asturiano, Dan Larhammar, Sylvie Dufour   +5 more
doaj   +1 more source

Insulin Increases Expression of TRPC6 Channels in Podocytes by a Calcineurin-Dependent Pathway

Cellular Physiology and Biochemistry, 2016
Background/Aims: Insulin signaling to podocytes is relevant for the function of the glomerulus. Now, we tested the hypothesis that insulin increases the surface expression of canonical transient receptor potential canonical type 6 (TRPC6) channels in ...
Shengqiang Xia, Ying Liu, Xinming Li, Florian Thilo, Martin Tepel   +4 more
doaj   +1 more source

Roles of transient receptor potential channels in pain [PDF]

Brain Research Reviews, 2009
Pain perception begins with the activation of primary sensory nociceptors. Over the past decade, flourishing research has revealed that members of the Transient Receptor Potential (TRP) ion channel family are fundamental molecules that detect noxious stimuli and transduce a diverse range of physical and chemical energy into action potentials in ...
Cheryl L, Stucky, Adrienne E, Dubin, Nathaniel A, Jeske, Sacha A, Malin, David D, McKemy, Gina M, Story   +5 more
openaire   +2 more sources

Upregulated TRPC3 and downregulated TRPC1 channel expression during hypertension is associated with increased vascular contractility in rat

Frontiers in Physiology, 2011
Transient receptor potential C1 and C3 (TRPC1 and TRPC3) are expressed in vascular smooth muscle cells and are thought to be involved in vascular contractility.
Muzamil M Noorani, Rebecca C Noel, Sean eMarrelli, Sean eMarrelli   +3 more
doaj   +1 more source

TRPV3-ANO1 interaction positively regulates wound healing in keratinocytes

Communications Biology, 2023
The chloride channel anoctamin1, upon activation by calcium influx through transient receptor potential vanilloid 3, mediates chloride influx and enhances wound healing in keratinocytes.
Yu Yamanoi, Jing Lei, Yasunori Takayama, Shigekuni Hosogi, Yoshinori Marunaka, Makoto Tominaga   +5 more
doaj   +1 more source

Canonical transient receptor potential channels in diabetes [PDF]

Experimental Biology and Medicine, 2012
Canonical transient receptor potential (TRPC) channel proteins have been identified as downstream molecules in a G protein-coupled receptor signaling pathway and are involved in a variety of cell functions due to their ability to regulate intracellular calcium signaling.
Sarabeth, Graham, Joseph P, Yuan, Rong, Ma   +2 more
openaire   +2 more sources

Cholesterol Stimulates the Transient Receptor Potential Melastatin 4 Channel in mpkCCDc14 Cells

Frontiers in Pharmacology, 2021
We have shown that cholesterol regulates the activity of ion channels in mouse cortical collecting duct (CCD) mpkCCDc14 cells and that the transient receptor potential melastatin 4 (TRPM4) channel is expressed in these cells.
Yong-Xu Cai, Bao-Long Zhang, Miao Yu, Yan-Chao Yang, Xue Ao, Di Zhu, Qiu-Shi Wang, Jie Lou, Chen Liang, Liang-Liang Tang, Ming-Ming Wu, Ming-Ming Wu, Zhi-Ren Zhang, Zhi-Ren Zhang, He-Ping Ma   +14 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Meclonazepam sensitivity of parasitic flatworms correlates with TRPMMCLZ sensitivity to meclonazepam

International Journal for Parasitology: Drugs and Drug Resistance
The ionotropic portfolio of parasitic flatworms affords considerable opportunity for development of new anthelmintics. In this regard, transient receptor potential ion channels (TRP channels), cation channels responsive to various physiochemical cues ...
Claudia M. Rohr, Paul McCusker, Marc Kaethner, Rebecca Armstrong, Emily Robb, Sang-Kyu Park, Daniel J. Sprague, Aaron G. Maule, Mostafa Zamanian, Britta Lundström-Stadelmann, John D. Chan, Jonathan S. Marchant   +11 more
doaj   +1 more source