Results 51 to 60 of about 11,727,590 (290)

Dynamic evolution of transient receptor potential vanilloid (TRPV) ion channel family with numerous gene duplications and losses

Frontiers in Endocrinology, 2022
The transient receptor potential vanilloid (TRPV) ion channel family is involved in multiple sensory and physiological functions including thermosensing and temperature-dependent neuroendocrine regulation.
Marina Morini, Marina Morini, Christina A. Bergqvist, Juan F. Asturiano, Dan Larhammar, Sylvie Dufour   +5 more
doaj   +1 more source

Activation of native TRPC1/C5/C6 channels by endothelin-1 is mediated by both PIP3 and PIP2 in rabbit coronary artery myocytes [PDF]

, 2009
We investigate activation mechanisms of native TRPC1/C5/C6 channels (termed TRPC1 channels) by stimulation of endothelin-1 (ET-1) receptor subtypes in freshly dispersed rabbit coronary artery myocytes using single channel recording and ...
Anthony P. Albert, Saleh, Sohag N., Albert, Anthony P., Sohag N. Saleh, William A. Large, Large, William A., Large, WA, Saleh, SN, Albert, AP   +8 more
core   +1 more source

Insulin Increases Expression of TRPC6 Channels in Podocytes by a Calcineurin-Dependent Pathway

Cellular Physiology and Biochemistry, 2016
Background/Aims: Insulin signaling to podocytes is relevant for the function of the glomerulus. Now, we tested the hypothesis that insulin increases the surface expression of canonical transient receptor potential canonical type 6 (TRPC6) channels in ...
Shengqiang Xia, Ying Liu, Xinming Li, Florian Thilo, Martin Tepel   +4 more
doaj   +1 more source

Upregulated TRPC3 and downregulated TRPC1 channel expression during hypertension is associated with increased vascular contractility in rat

Frontiers in Physiology, 2011
Transient receptor potential C1 and C3 (TRPC1 and TRPC3) are expressed in vascular smooth muscle cells and are thought to be involved in vascular contractility.
Muzamil M Noorani, Rebecca C Noel, Sean eMarrelli, Sean eMarrelli   +3 more
doaj   +1 more source

The Transient Receptor Potential Superfamily of Ion Channels [PDF]

Journal of the American Society of Nephrology, 2004
ABSTRACT. The transient receptor potential (TRP) superfamily of proteins is cation-selective ion channels with six predicted transmembrane segments and intracellularly localized amino and carboxyl termini. Members of the TRP superfamily are identified on the basis of amino acid sequence and structural similarity and are classified into TRPC, TRPV, TRPM,
openaire   +2 more sources

Canonical transient receptor potential channels in diabetes [PDF]

Experimental Biology and Medicine, 2012
Canonical transient receptor potential (TRPC) channel proteins have been identified as downstream molecules in a G protein-coupled receptor signaling pathway and are involved in a variety of cell functions due to their ability to regulate intracellular calcium signaling.
Sarabeth, Graham, Joseph P, Yuan, Rong, Ma   +2 more
openaire   +2 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Remodelling of human atrial K+ currents but not ion channel expression by chronic β-blockade [PDF]

, 2011
Chronic β-adrenoceptor antagonist (β-blocker) treatment in patients is associated with a potentially anti-arrhythmic prolongation of the atrial action potential duration (APD), which may involve remodelling of repolarising K+ currents.
Currie, S., Tellez, James O, Julie A. Russell, Kane, Kathleen A, Jhund, Pardeep S, Boyett, M.R., Rankin, A.C., Pardeep S. Jhund, Mark R. Boyett, Dempster, John, Marshall, Gillian E., John Dempster, Currie, Susan, Russell, J.A., Workman, Antony J., Marshall, Gillian E, Workman, A.J., Marshall, G.E., Russell, Julie A, Dempster, J., Rankin, Andrew C, Russell, Julie A., Gillian E. Marshall, Tellez, James O., Boyett, Mark R, Kathleen A. Kane, Boyett, Mark R., Andrew C. Rankin, Rankin, Andrew C., Kane, K.A., Workman, Antony J, Tellez, J.O., Antony J. Workman, Kane, Kathleen A., Jhund, P.S., Susan Currie, James O. Tellez, Jhund, Pardeep S.   +37 more
core   +1 more source

Meclonazepam sensitivity of parasitic flatworms correlates with TRPMMCLZ sensitivity to meclonazepam

International Journal for Parasitology: Drugs and Drug Resistance
The ionotropic portfolio of parasitic flatworms affords considerable opportunity for development of new anthelmintics. In this regard, transient receptor potential ion channels (TRP channels), cation channels responsive to various physiochemical cues ...
Claudia M. Rohr, Paul McCusker, Marc Kaethner, Rebecca Armstrong, Emily Robb, Sang-Kyu Park, Daniel J. Sprague, Aaron G. Maule, Mostafa Zamanian, Britta Lundström-Stadelmann, John D. Chan, Jonathan S. Marchant   +11 more
doaj   +1 more source

The Role of Transient Receptor Potential Channel 6 Channels in the Pulmonary Vasculature

Frontiers in Immunology, 2017
Canonical or classical transient receptor potential channel 6 (TRPC6) is a Ca2+-permeable non-selective cation channel that is widely expressed in the heart, lung, and vascular tissues.
Monika Malczyk, Alexandra Erb, Christine Veith, Hossein Ardeschir Ghofrani, Ralph T. Schermuly, Thomas Gudermann, Alexander Dietrich, Norbert Weissmann, Akylbek Sydykov   +8 more
doaj   +1 more source