Results 61 to 70 of about 11,727,590 (290)

Cholesterol Stimulates the Transient Receptor Potential Melastatin 4 Channel in mpkCCDc14 Cells

Frontiers in Pharmacology, 2021
We have shown that cholesterol regulates the activity of ion channels in mouse cortical collecting duct (CCD) mpkCCDc14 cells and that the transient receptor potential melastatin 4 (TRPM4) channel is expressed in these cells.
Yong-Xu Cai, Bao-Long Zhang, Miao Yu, Yan-Chao Yang, Xue Ao, Di Zhu, Qiu-Shi Wang, Jie Lou, Chen Liang, Liang-Liang Tang, Ming-Ming Wu, Ming-Ming Wu, Zhi-Ren Zhang, Zhi-Ren Zhang, He-Ping Ma   +14 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Transient receptor potential ankyrin 1 channel localized to non-neuronal airway cells promotes non-neurogenic inflammation [PDF]

, 2012
The transient receptor potential ankyrin 1 (TRPA1) channel, localized to airway sensory nerves, has been proposed to mediate airway inflammation evoked by allergen and cigarette smoke (CS) in rodents, via a neurogenic mechanism.
Charlott Brunmark, Pierangelo Geppetti, Riccardo Patacchini (144063), Nassini, Romina, Anders B Damholt, Pedretti Pamela, Riccardo Patacchini, Serena Materazzi, Lorcan McGarvey (144059), Fusi, C, Camilla Fusi (144024), Arturo Roberto Viscomi (144036), Charlott Brunmark (144052), Facchinetti, F, Geppetti, P, Anna Rita Pisano, Romina Nassini (144009), Pisano, Anna Rita, Damholt Anders B., Brunmark, Charlott, Materazzi Serena, Naila Svitacheva, Patacchini, Riccardo, Damholt, Anders B., Naila Svitacheva (144057), Materazzi, S., Fabrizio Facchinetti (144032), Anders B. Damholt (144066), Fusi Camilla, Pamela Pedretti, Susan Stokesberry (144046), Pierangelo Geppetti (144069), Moretto Nadia, Lorcan McGarvey, Patacchini, R, Nassini Romina, Patacchini Riccardo, Facchinetti Fabrizio, Svitacheva Naila, Serena Materazzi (144070), Brunmark Charlott, Carnini Chiara, Stokesberry, Susan, Romina Nassini, Chiara Carnini, Materazzi, Serena, Anna Rita Pisano (144040), Geppetti, Pierangelo, Viscomi, Arturo Roberto, Stokesberry Susan, Viscomi Arturo Roberto, Moretto, Nadia, Damholt, Anders B, Chiara Carnini (144028), Susan Stokesberry, Facchinetti, Fabrizio, Nassini, R, Pedretti, Pamela, Carnini, Chiara, Nadia Moretto, Geppetti Pierangelo, McGarvey, Lorcan, Pisano Anna Rita, McGarvey Lorcan, Arturo Roberto Viscomi, Fusi, Camilla, Fabrizio Facchinetti, Svitacheva, Naila, Pedretti, P, Camilla Fusi, Pamela Pedretti (144015), Nadia Moretto (144020)   +71 more
core   +2 more sources

TRPtracker: a community database for monitoring praziquantel sensitivity at TRPMPZQ variants

International Journal for Parasitology: Drugs and Drug Resistance
The anthelmintic praziquantel (PZQ) has been used for decades as the clinical therapy for schistosomiasis, and remains the only available drug. As a cheap and effective drug therapy for all human disease-causing Schistosoma species, usage of PZQ ...
Claudia M. Rohr, Sang-Kyu Park, Kelsilandia Aguiar-Martins, Timothy J.C. Anderson, Duncan J. Berger, Matthew Berriman, Sarah K. Buddenborg, Amaya L. Bustinduy, Frédéric D. Chevalier, James A. Cotton, Thomas Crellen, Stephen R. Doyle, Aidan M. Emery, Julien Kincaid Smith, Safari Kinung'hi, Poppy H.L. Lamberton, Winka Le Clec'h, Eric Ndombi, Tom Pennance, Candia Rowel, Shannan S. Summers, John Vianney Tushabe, Martin Walker, Bonnie L. Webster, Joanne P. Webster, Shona Wilson, Jonathan S. Marchant   +26 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

TRPV3-ANO1 interaction positively regulates wound healing in keratinocytes

Communications Biology, 2023
The chloride channel anoctamin1, upon activation by calcium influx through transient receptor potential vanilloid 3, mediates chloride influx and enhances wound healing in keratinocytes.
Yu Yamanoi, Jing Lei, Yasunori Takayama, Shigekuni Hosogi, Yoshinori Marunaka, Makoto Tominaga   +5 more
doaj   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

The Transient Receptor Potential Vanilloid 4 Channel and Cardiovascular Disease Risk Factors

Frontiers in Physiology, 2021
Vascular endothelial cells regulate arterial tone through the release of nitric oxide and other diffusible factors such as prostacyclin and endothelium derived hyperpolarizing factors.
Kenichi Goto, Takanari Kitazono
doaj   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source