Results 71 to 80 of about 11,727,590 (290)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Transient receptor potential melastatin 4 channel contributes to migration of androgen-insensitive prostate cancer cells. [PDF]

, 2015
Impaired Ca2+ signaling in prostate cancer contributes to several cancer hallmarks, such as enhanced proliferation and migration and a decreased ability to induce apoptosis.
Kappel, Sven, Holzmann, Christian, Urban, Sabine Katharina, Rother, Karen, Kilch, Tatiana, Jochum, Marcus Martin, Peinelt, Christine, Greiner, Markus, Jung, Volker, Stöckle, Michael   +9 more
core   +2 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

The Role of Transient Receptor Potential Channels in Metabolic Syndrome [PDF]

Hypertension Research, 2008
Metabolic syndrome is correlated with increased cardiovascular risk and characterized by several factors, including visceral obesity, hypertension, insulin resistance, and dyslipidemia. Several members of a large family of nonselective cation entry channels, e.g., transient receptor potential (TRP) canonical (TRPC), vanilloid (TRPV), and melastatin ...
Liu, Daoyan, Zhu, Zhiming, Tepel, Martin
openaire   +2 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Transient Receptor Potential Cation Channels in Cancer Therapy [PDF]

Medical Sciences, 2019
In mammals, the transient receptor potential (TRP) channels family consists of six different families, namely TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPML (mucolipin), TRPP (polycystin), and TRPA (ankyrin), that are strictly connected with cancer cell proliferation, differentiation, cell death, angiogenesis, migration, and invasion ...
Santoni, Giorgio, Maggi, Federica, Morelli, Maria Beatrice, Santoni, Matteo, Marinelli, Oliviero   +4 more
openaire   +4 more sources

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

High glucose-induced oxidative stress increases transient receptor potential channel expression in human monocytes

, 2010
Transient receptor potential (TRP) channel-induced cation influx activates human monocytes, which play an important role in the pathogenesis of atherosclerosis. In the present study, we investigated the effects of high glucose-induced oxidative stress on
Ristow, Michael, Scholze, Alexandra; id_orcid, Wuensch, Tilo, Krueger, Katharina, Tepel, Martin; id_orcid, Thilo, Florian   +5 more
core   +1 more source

TRPM7 (Transient Receptor Potential Melastatin-Like 7 Channel) Kinase Controls Calcium Responses in Arterial Thrombosis and Stroke in Mice [PDF]

, 2017
Objective: TRPM7 (transient receptor potential cation channel, subfamily M, member 7) is a ubiquitously expressed bifunctional protein comprising a transient receptor potential channel segment linked to a cytosolic alpha-type serine/threonine protein ...
Stritt, Simon, Peter J. Noy, Vladimir Chubanov, Schmitz, Carsten, Sanjeev K. Gotru, Michael G. Tomlinson, Isabelle C. Becker, Bernhard Nieswandt, Thomas Gudermann, Rao, Deviyani, Dandekar, Thomas, Peter Kraft, Zierler, Susanna, Thomas Dandekar, Simon Stritt, Anne-Laure Perraud, René P. Zahedi, Wolf, Karen, Becker, Isabelle C., Stoll, Guido, Karen Wolf, Gotru, Sanjeev K., Noy, Peter J., Attila Braun, Perraud, Anne-Laure, Chen, Wenchun, Zahedi, Rene P., Guido Stoll, Masayuki Matsushita, Chubanov, Vladimir, Hermanns, Heike M., Nieswandt, Bernhard, Kraft, Peter, Tomlinson, Michael G., Gudermann, Thomas, Braun, Attila, Wenchun Chen, Heike M. Hermanns, Deviyani Rao, Susanna Zierler, Carsten Schmitz, Matsushita, Masayuki, Tomlinson, Michael; id_orcid   +42 more
core   +2 more sources

Pharmacology of Vanilloid Transient Receptor Potential Cation Channels [PDF]

Molecular Pharmacology, 2009
Depending on their primary structure, the 28 mammalian transient receptor potential (TRP) cation channels identified so far can be sorted into 6 subfamilies: TRPC ("Canonical"), TRPV ("Vanilloid"), TRPM ("Melastatin"), TRPP ("Polycystin"), TRPML ("Mucolipin"), and TRPA ("Ankyrin").
Vriens, Joris, Appendino, Giovanni, Nilius, Bernd   +2 more
openaire   +5 more sources