Results 91 to 100 of about 238,661 (303)

Transient Receptor Potential (TRP) Channels in Health and Disease

Cells, 2019
Almost 25 years ago, the first mammalian transient receptor potential (TRP) channel, now named TRPC1, was cloned and published (reviewed in [...]
Alexander Dietrich
doaj   +1 more source

Antiviral Effects of Menthol on Coxsackievirus B

Viruses, 2020
Coxsackievirus B (CVB) is a common human enterovirus that causes systemic infection but specifically replicates to high titers in the pancreas. It was reported that certain viruses induce mitochondrial fission to support infection. We documented that CVB
David J.R. Taylor, Syed M. Hamid, Allen M. Andres, Hannaneh Saadaeijahromi, Honit Piplani, Juliana F. Germano, Yang Song, Savannah Sawaged, Ralph Feuer, Stephen J. Pandol, Jon Sin   +10 more
doaj   +1 more source

Transient Receptor Potential Canonical Channels in Health and Disease: A 2020 Update

Cells, 2021
This 2020 Special Issue “TRPC channels” of Cells was dedicated to commemorating the 25th anniversary of discovery of the Transient Receptor Potential Canonical (TRPC) channel subfamily [...]
Priya R. Kirtley, Gagandeep S. Sooch, Fletcher A. White, Alexander G. Obukhov   +3 more
doaj   +1 more source

Dominant mutations in the cation channel gene transient receptor potential vanilloid 4 cause an unusual spectrum of neuropathies [PDF]

, 2017
Hereditary neuropathies form a heterogeneous group of disorders for which over 40 causal genes have been identified to date. Recently, dominant mutations in the transient receptor potential vanilloid 4 gene were found to be associated with three distinct
Auer-Grumbach, Michaela, Baets, Jonathan, Barisic, Nina, Berciano, José, Boltshauser, Eugen, Crosby, Andrew H., Fischbeck, Kenneth H., Garcia, Antonio, Gaudet, Rachelle, Hilton-Jones, David, Houlden, Henry, Jonghe, Peter De, Jordanova, Albena, Landouré, Guida, Lopez-Laso, Eduardo, Ludlow, Christy L., McEntagart, Meriel, Merlini, Luciano, Reilly, Mary M., Shaw, Christopher E., Sumner, Charlotte J., Timmerman, Vincent, Zimoń, Magdalena   +22 more
core  

Understand spiciness: mechanism of TRPV1 channel activation by capsaicin. [PDF]

, 2017
Capsaicin in chili peppers bestows the sensation of spiciness. Since the discovery of its receptor, transient receptor potential vanilloid 1 (TRPV1) ion channel, how capsaicin activates this channel has been under extensive investigation using a variety ...
Yang, Fan, Zheng, Jie
core   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

TRPA1 mediates aromatase inhibitor-evoked pain by the aromatase substrate androstenedione [PDF]

, 2016
Aromatase inhibitors (AI) induce painful musculoskeletal symptoms (AIMSS), which are dependent upon the pain transducing receptor TRPA1. However, as the AI concentrations required to engage TRPA1 in mice are higher than those found in the plasma of ...
Benemei, Silvia, Coppi, Elisabetta, De Logu, Francesco, Di Tommaso, Mariarosaria, Fusi, Camilla, Geppetti, Pierangelo, Li Puma, Simone, Marone, Ilaria M., Materazzi, Serena, Moneti, Gloriano, Morice, Alyn H., Nassini, Romina, Sadofsky, Laura R., Susini, Tommaso, Terreni, Alessandro, Tonello, Raquel   +15 more
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

3-Iodothyronamine, a Novel Endogenous Modulator of Transient Receptor Potential Melastatin 8?

Frontiers in Endocrinology, 2017
The decarboxylated and deiodinated thyroid hormone (TH) derivative, 3-iodothyronamine (3-T1AM), is suggested to be involved in energy metabolism and thermoregulation.
Noushafarin Khajavi, Stefan Mergler, Heike Biebermann   +2 more
doaj   +1 more source