Results 101 to 110 of about 11,727,590 (290)

KDAC6 alters cell morphology and motility through positive and negative modulation of F‐actin distribution

FEBS Open Bio, EarlyView.
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph, Andrea B. Pham, Kiara E. Bornes, Razan H. Hammad, Chelsea A. Rousseve‐Ross, Thomas M. Huckaba, Terry J. Watt, Tasha B. Toro   +7 more
wiley   +1 more source

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

Natural-Product-Derived Transient Receptor Potential Melastatin 8 (TRPM8) Channel Modulators

, 2016
A library of novel structural hybrids of menthol and cubebol was tested for each derivative’s ability to interact with the transient receptor potential subfamily melastatin member 8 (TRPM8) channel.
Evgueni Gorobets (2741056), Darren J. Derksen (2297485), Christina M. LeGay (2741062), Rithwik Ramachandran (195347), Mircea Iftinca (2741059), Christophe Altier (87127)   +5 more
core   +1 more source

Transient Receptor Potential Channels as Targets for Phytochemicals [PDF]

ACS Chemical Neuroscience, 2014
To date, 28 mammalian transient receptor potential (TRP) channels have been cloned and characterized. They are grouped into six subfamilies on the basis of their amino acid sequence homology: TRP Ankyrin (TRPA), TRP Canonical (TRPC), TRP Melastatin (TRPM), TRP Mucolipin (TRPML), TRP Polycystin (TRPP), and TRP Vanilloid (TRPV).
openaire   +2 more sources

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

The paradoxical role of the transient receptor potential vanilloid 1 receptor in inflammation

, 2010
The transient potential receptor vanilloid 1 (TRPV1) receptor is a non-selective cation channel that is chemically activated by capsaicin, the pungent component of hot peppers.
Keeble, Julie; id_orcid, Julie Keeble, Khadija Alawi, Alawi, Khadija   +3 more
core   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Data_Sheet_1_Function of Transient Receptor Potential-Like Channel in Insect Egg Laying.pdf

, 2022
The transient receptor potential-like channel (TRPL) is a member of the transient receptor potential (TRP) channel family involved in regulating many fundamental senses, such as vision, pain, taste, and touch, in both invertebrates and vertebrates.
Yali V. Zhang (12978527), Shun-Fan Wu (462256), Cong-Fen Gao (11278523), Yan Zhang (8098), Yi-Jie Zhang (713506), Li-Xiang Wang (4249732), Chun-Dong Niu (12978524), Di Guo (718480)   +7 more
core   +1 more source

Role of transient receptor potential melastatin type 7 channel in gastric cancer

Integrative Medicine Research, 2016
Transient receptor potential (TRP) proteins are a family of ion channels, which are responsible for a wide array of cellular functions. In particular, TRP melastatin type (TRPM) 7 is expressed everywhere and permeable to divalent cations such as Mg2+ and
Byung Joo Kim, Chansik Hong
doaj   +1 more source

Transient receptor potential channels and energy homeostasis

Trends in Endocrinology & Metabolism, 2013
Transient receptor potential (TRP) channels are members of an ancient class of ion channels that are present in most mammalian tissues. Consistent with their wide tissue distribution, TRPs are capable of influencing diverse physiological processes including adipocyte function, energy intake and energy expenditure. TRPs function as transduction channels
openaire   +3 more sources