Results 31 to 40 of about 127,083 (259)
The TRPA1 Channel in the Cardiovascular System: Promising Features and Challenges
Frontiers in Pharmacology, 2019 The transient receptor potential ankyrin 1 (TRPA1) channel is a calcium-permeable nonselective cation channel in the plasma membrane that belongs to the transient receptor potential (TRP) channel superfamily.
Zhen Wang +25 more
doaj +1 more source
Calcium-Permeable Channels Cooperation for Rheumatoid Arthritis: Therapeutic Opportunities
Biomolecules, 2022 Rheumatoid arthritis is a common autoimmune disease that results from the deposition of antibodies–autoantigens in the joints, leading to long-lasting inflammation.
Hong-Yu Liang +6 more
doaj +1 more source
Flavaglines Stimulate Transient Receptor Potential Melastatin Type 6 (TRPM6) Channel Activity. [PDF]
PLoS ONE, 2015 Magnesium (Mg2+) is essential for enzymatic activity, brain function and muscle contraction. Blood Mg2+ concentrations are tightly regulated between 0.7 and 1.1 mM by Mg2+ (re)absorption in kidney and intestine.
Maxime G Blanchard +8 more
doaj +1 more source
Transient receptor potential channels meet phosphoinositides [PDF]
The EMBO Journal, 2008 Transient receptor potential (TRP) cation channels are unique cellular sensors that are involved in multiple cellular functions, ranging from transduction of sensory signals to the regulation of Ca(2+) and Mg(2+) homoeostasis. Malfunctioning of TRP channels is now recognized as the cause of several hereditary and acquired human diseases. At the time of
Nilius, Bernd +2 more
openaire +3 more sources
Transient receptor potential melastatin 1: a hair cell transduction channel candidate. [PDF]
PLoS ONE, 2013 Sound and head movements are perceived through sensory hair cells in the inner ear. Mounting evidence indicates that this process is initiated by the opening of mechanically sensitive calcium-permeable channels, also referred to as the mechanoelectrical ...
John Gerka-Stuyt +3 more
doaj +1 more source
Frontiers in Cardiovascular Medicine, 2022 Heart failure (HF) remains the leading cause of death, morbidity, and medical expenses worldwide. Treatments for HF with reduced ejection fraction have progressed in recent years; however, acute decompensated heart failure remains difficult to treat. The
Kun Ding +7 more
doaj +1 more source
Modulation of Transient Receptor Potential C Channel Activity by Cholesterol
Frontiers in Pharmacology, 2019 Changes of cholesterol level in the plasma membrane of cells have been shown to modulate ion channel function. The proposed mechanisms underlying these modulations include association of cholesterol to a single binding site at a single channel ...
Rita Gutorov +6 more
doaj +1 more source
Responses to transient receptor potential (TRP) channel agonists in Chlamydomonas reinhardtii
Biology Open, 2020 Pungent substances, such as capsaicin and gingerol, activate the transient receptor potential (TRP)-V1 channel and affect the feeding behaviors of animals.
Mamoru Wada +2 more
doaj +1 more source
Structural insights into TRPV2 activation by small molecules
Nature Communications, 2022 A non-selective calcium channel transient receptor potential vanilloid 2 (TRPV2) is a potential drug target. Here, the authors employ cryo-electron microscopy, in silico docking, and electrophysiology to identify a binding site for an activator 2 ...
Ruth A. Pumroy +11 more
doaj +1 more source
Transient Receptor Potential Channels and Metabolism.
Molecules and cells, 2019 Transient receptor potential (TRP) channels are nonselective cationic channels, conserved among flies to humans. Most TRP channels have well known functions in chemosensation, thermosensation, and mechanosensation. In addition to being sensing environmental changes, many TRP channels are also internal sensors that help maintain homeostasis.
Dhakal, Subash, Lee, Youngseok
openaire +2 more sources