Results 31 to 40 of about 11,727,590 (290)

Transient receptor potential channels in Alzheimer's disease

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2007
Cognitive impairment and emotional disturbances in Alzheimer's disease (AD) result from the degeneration of synapses and neuronal death in the limbic system and associated regions of the cerebral cortex. An alteration in the proteolytic processing of the amyloid precursor protein (APP) results in increased production and accumulation of amyloid beta ...
Yamamoto, Shinichiro, Wajima, Teruaki, Hara, Yuji, Nishida, Motohiro, Mori, Yasuo   +4 more
openaire   +2 more sources

TRPM1 (transient receptor potential cation channel, subfamily M, member 1) [PDF]

, 2010
Review on TRPM1 (transient receptor potential cation channel, subfamily M, member 1), with data on DNA, on the protein encoded, and where the gene is ...
Setaluri, V, S Devi, V Setaluri, Devi, S
core   +1 more source

TRPM8 (transient receptor potential cation channel, subfamily M, member 8) [PDF]

, 2013
Review on TRPM8 (transient receptor potential cation channel, subfamily M, member 8), with data on DNA, on the protein encoded, and where the gene is ...
Valero, ML, Pardo, LA
core   +1 more source

Function of Transient Receptor Potential-Like Channel in Insect Egg Laying

Frontiers in Molecular Neuroscience, 2022
The transient receptor potential-like channel (TRPL) is a member of the transient receptor potential (TRP) channel family involved in regulating many fundamental senses, such as vision, pain, taste, and touch, in both invertebrates and vertebrates.
Yan Zhang, Yi-Jie Zhang, Di Guo, Li-Xiang Wang, Chun-Dong Niu, Shun-Fan Wu, Yali V. Zhang, Cong-Fen Gao   +7 more
doaj   +1 more source

Enhanced itch elicited by capsaicin in a chronic itch model

Molecular Pain, 2016
Chronic itch (pruritus) is an important clinical problem. However, the underlying molecular basis has yet to be understood. The Transient Receptor Potential Vanilloid 1 channel is a heat-sensitive cation channel expressed in primary sensory neurons and ...
Guang Yu PhD, Niuniu Yang MD, Fengxian Li MD, Meijuan Chen PhD, Changxiong J Guo BS, Changming Wang PhD, Danyou Hu BS, Yan Yang BS, Chan Zhu BS, Zhongli Wang PhD, Hao Shi MD, Tana Gegen MD, Ming Tang MS, Qian He MS, Qin Liu PhD, Zongxiang Tang PhD   +15 more
doaj   +1 more source

Flavaglines Stimulate Transient Receptor Potential Melastatin Type 6 (TRPM6) Channel Activity. [PDF]

PLoS ONE, 2015
Magnesium (Mg2+) is essential for enzymatic activity, brain function and muscle contraction. Blood Mg2+ concentrations are tightly regulated between 0.7 and 1.1 mM by Mg2+ (re)absorption in kidney and intestine.
Maxime G Blanchard, Jeroen H F de Baaij, Sjoerd A J Verkaart, Anke L Lameris, Christine Basmadjian, Qian Zhao, Laurent Désaubry, René J M Bindels, Joost G J Hoenderop   +8 more
doaj   +1 more source

The asparagine 533 residue in the outer pore loop region of the mouse PKD2L1 channel is essential for its voltage‐dependent inactivation

FEBS Open Bio, 2017
Voltage‐dependent inactivation of ion channels contributes to the regulation of the membrane potential of excitable cells. Mouse polycystic kidney disease 2‐like 1 (PKD2L1) forms voltage‐dependent nonselective cation channels, which are activated but ...
Takahiro Shimizu, Taiga Higuchi, Toshihiro Toba, Chie Ohno, Takuto Fujii, Bernd Nilius, Hideki Sakai   +6 more
doaj   +1 more source

The TRPA1 Channel in the Cardiovascular System: Promising Features and Challenges

Frontiers in Pharmacology, 2019
The transient receptor potential ankyrin 1 (TRPA1) channel is a calcium-permeable nonselective cation channel in the plasma membrane that belongs to the transient receptor potential (TRP) channel superfamily.
Zhen Wang, Zhen Wang, Zhen Wang, Di Ye, Di Ye, Di Ye, Jing Ye, Jing Ye, Jing Ye, Menglong Wang, Menglong Wang, Menglong Wang, Jianfang Liu, Jianfang Liu, Jianfang Liu, Huimin Jiang, Huimin Jiang, Huimin Jiang, Yao Xu, Yao Xu, Yao Xu, Jishou Zhang, Jiangbin Chen, Jun Wan, Jun Wan, Jun Wan   +25 more
doaj   +1 more source

Transient receptor potential melastatin 1: a hair cell transduction channel candidate. [PDF]

PLoS ONE, 2013
Sound and head movements are perceived through sensory hair cells in the inner ear. Mounting evidence indicates that this process is initiated by the opening of mechanically sensitive calcium-permeable channels, also referred to as the mechanoelectrical ...
John Gerka-Stuyt, Adrian Au, Neal S Peachey, Kumar N Alagramam   +3 more
doaj   +1 more source

Calcium-Permeable Channels Cooperation for Rheumatoid Arthritis: Therapeutic Opportunities

Biomolecules, 2022
Rheumatoid arthritis is a common autoimmune disease that results from the deposition of antibodies–autoantigens in the joints, leading to long-lasting inflammation.
Hong-Yu Liang, Huan-Xin Yin, Shu-Fang Li, Yong Chen, Ying-Jie Zhao, Wei Hu, Ren-Peng Zhou   +6 more
doaj   +1 more source