Results 11 to 20 of about 11,016,750 (197)

A novel ion channel formed by interaction of TRPML3 with TRPV5. [PDF]

, 2013
TRPML3 and TRPV5 are members of the mucolipin (TRPML) and TRPV subfamilies of transient receptor potential (TRP) cation channels. Based on sequence similarities of the pore forming regions and on structure-function evidence, we hypothesized that the pore
Becker, Lars, Anthony J Ricci, Grimm, Christian, Heller, Stefan, Anthony J. Ricci (212303), Ricci, Anthony J., Stefan Heller, Lars Becker (358879), Zhaohua Guo (383295), Zhaohua Guo, Stefan Heller (36641), Guo, Zhaohua, Lars Becker, Christian Grimm, Christian Grimm (84987)   +14 more
core   +2 more sources

Activation of native TRPC1/C5/C6 channels by endothelin-1 is mediated by both PIP3 and PIP2 in rabbit coronary artery myocytes [PDF]

, 2009
We investigate activation mechanisms of native TRPC1/C5/C6 channels (termed TRPC1 channels) by stimulation of endothelin-1 (ET-1) receptor subtypes in freshly dispersed rabbit coronary artery myocytes using single channel recording and ...
Anthony P. Albert, Saleh, Sohag N., Albert, Anthony P., Sohag N. Saleh, William A. Large, Large, William A., Large, WA, Saleh, SN, Albert, AP   +8 more
core   +1 more source

Emergence of functional sensory subtypes as defined by transient receptor potential channel expression [PDF]

, 2007
The existence of heterogeneous populations of dorsal root ganglion (DRG) neurons conveying different somatosensory information is the basis for the perception of touch, temperature, and pain. A differential expression of transient receptor potential (TRP)
Hjerling-Leffler, J, Ernfors, P, Ernfors, P,, Koltzenburg, M, AlQatari, M   +4 more
core   +1 more source

The effect of chronic constriction injury after a period of endurance training on the expression of TRPC1 and TRPC3 in the plantaris muscle of male Wistar rats [PDF]

فصلنامه ابن سینا, 2023
Background and aims: Due to the role of TRPC1/3 in muscle atrophy, this study aimed to investigate the effect of Chronic Constriction Injury (CCI) after a period of endurance training on TRPC1/3 gene expression in the plantaris muscle of male Wistar rats.
Abdolreza Kazemi, Hadi Kerendi, Parvaneh Dinarzehi, Naimeh Nekoie   +3 more
doaj  

Inhibition of native TRPC6 channel activity by phosphatidylinositol 4,5-bisphosphate in mesenteric artery myocytes [PDF]

, 2008
The present work investigates the effect of phosphatidylinositol-4,5-bisphosphate (PIP2) on native TRPC6 channel activity in freshly dispersed rabbit mesenteric artery myocytes using patch clamp recording and co-immunoprecipitation methods.
Saleh, Sohag N., Albert, Anthony P., Large, William A., Large, WA, Saleh, SN, Albert, AP   +5 more
core   +1 more source

Function of Transient Receptor Potential-Like Channel in Insect Egg Laying

Frontiers in Molecular Neuroscience, 2022
The transient receptor potential-like channel (TRPL) is a member of the transient receptor potential (TRP) channel family involved in regulating many fundamental senses, such as vision, pain, taste, and touch, in both invertebrates and vertebrates.
Yan Zhang, Yi-Jie Zhang, Di Guo, Li-Xiang Wang, Chun-Dong Niu, Shun-Fan Wu, Yali V. Zhang, Cong-Fen Gao   +7 more
doaj   +1 more source

Remodelling of human atrial K+ currents but not ion channel expression by chronic β-blockade [PDF]

, 2011
Chronic β-adrenoceptor antagonist (β-blocker) treatment in patients is associated with a potentially anti-arrhythmic prolongation of the atrial action potential duration (APD), which may involve remodelling of repolarising K+ currents.
Currie, S., Tellez, James O, Julie A. Russell, Kane, Kathleen A, Jhund, Pardeep S, Boyett, M.R., Rankin, A.C., Pardeep S. Jhund, Mark R. Boyett, Dempster, John, Marshall, Gillian E., John Dempster, Currie, Susan, Russell, J.A., Workman, Antony J., Marshall, Gillian E, Workman, A.J., Marshall, G.E., Russell, Julie A, Dempster, J., Rankin, Andrew C, Russell, Julie A., Gillian E. Marshall, Tellez, James O., Boyett, Mark R, Kathleen A. Kane, Boyett, Mark R., Andrew C. Rankin, Rankin, Andrew C., Kane, K.A., Workman, Antony J, Tellez, J.O., Antony J. Workman, Kane, Kathleen A., Jhund, P.S., Susan Currie, James O. Tellez, Jhund, Pardeep S.   +37 more
core   +1 more source

Enhanced itch elicited by capsaicin in a chronic itch model

Molecular Pain, 2016
Chronic itch (pruritus) is an important clinical problem. However, the underlying molecular basis has yet to be understood. The Transient Receptor Potential Vanilloid 1 channel is a heat-sensitive cation channel expressed in primary sensory neurons and ...
Guang Yu PhD, Niuniu Yang MD, Fengxian Li MD, Meijuan Chen PhD, Changxiong J Guo BS, Changming Wang PhD, Danyou Hu BS, Yan Yang BS, Chan Zhu BS, Zhongli Wang PhD, Hao Shi MD, Tana Gegen MD, Ming Tang MS, Qian He MS, Qin Liu PhD, Zongxiang Tang PhD   +15 more
doaj   +1 more source

Flavaglines Stimulate Transient Receptor Potential Melastatin Type 6 (TRPM6) Channel Activity. [PDF]

PLoS ONE, 2015
Magnesium (Mg2+) is essential for enzymatic activity, brain function and muscle contraction. Blood Mg2+ concentrations are tightly regulated between 0.7 and 1.1 mM by Mg2+ (re)absorption in kidney and intestine.
Maxime G Blanchard, Jeroen H F de Baaij, Sjoerd A J Verkaart, Anke L Lameris, Christine Basmadjian, Qian Zhao, Laurent Désaubry, René J M Bindels, Joost G J Hoenderop   +8 more
doaj   +1 more source

The asparagine 533 residue in the outer pore loop region of the mouse PKD2L1 channel is essential for its voltage‐dependent inactivation

FEBS Open Bio, 2017
Voltage‐dependent inactivation of ion channels contributes to the regulation of the membrane potential of excitable cells. Mouse polycystic kidney disease 2‐like 1 (PKD2L1) forms voltage‐dependent nonselective cation channels, which are activated but ...
Takahiro Shimizu, Taiga Higuchi, Toshihiro Toba, Chie Ohno, Takuto Fujii, Bernd Nilius, Hideki Sakai   +6 more
doaj   +1 more source