Results 61 to 70 of about 23,681 (244)

Polysulfide Evokes Acute Pain through the Activation of Nociceptive TRPA1 in Mouse Sensory Neurons

Molecular Pain, 2015
Background Hydrogen sulfide (H 2 S) is oxidized to polysulfide. Recent reports show that this sulfur compound modulates various biological functions. We have reported that H 2 S is involved in inflammatory pain in mice. On the other hand, little is known
Yukari Hatakeyama, Kenji Takahashi, Makoto Tominaga, Hideo Kimura, Toshio Ohta   +4 more
doaj   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

TRPA1 has a key role in the somatic pro-nociceptive actions of hydrogen sulfide. [PDF]

PLoS ONE, 2012
Hydrogen sulfide (H(2)S), which is produced endogenously from L-cysteine, is an irritant with pro-nociceptive actions. We have used measurements of intracellular calcium concentration, electrophysiology and behavioral measurements to show that the ...
David A Andersson, Clive Gentry, Stuart Bevan   +2 more
doaj   +1 more source

Sono‐Mechanogenetics: Linking Ultrasound Physics With Cellular Mechanobiology

Advanced Science, EarlyView.
Sono‐mechanogenetics links ultrasound physics with cellular mechanotransduction to enable noninvasive control of engineered biological systems. Acoustic forces generate distinct deformation modes that activate intracellular signaling pathways, which can be coupled to synthetic gene circuits to regulate diverse cellular functions, including gene ...
Yunjia Qu, Fan Wei, Chi Woo Yoon, Qifa Zhou, Yingxiao Wang   +4 more
wiley   +1 more source

TMEM100, a regulator of TRPV1-TRPA1 interaction, contributes to temporomandibular disorder pain

Frontiers in Molecular Neuroscience, 2023
There is an unmet need to identify new therapeutic targets for temporomandibular disorder (TMD) pain because current treatments are limited and unsatisfactory.
Peng Wang, Qiaojuan Zhang, Fabiana C. Dias, Abbie Suttle, Xinzhong Dong, Yong Chen, Yong Chen, Yong Chen   +7 more
doaj   +1 more source

Zebrafish TRPA1 Channels Are Required for Chemosensation But Not for Thermosensation or Mechanosensory Hair Cell Function [PDF]

, 2008
Transient receptor potential (TRP) ion channels have been implicated in detecting chemical, thermal, and mechanical stimuli in organisms ranging from mammals to Caenorhabditis elegans.
Caron, Sophie, Hudspeth, A. J., Julius, David, Kim, Seok-Hyung, McDermott, Brian M., Jr., Myers, Benjamin R., Prober, David A., Rihel, Jason, Schier, Alexander F., Solnica-Krezel, Lilianna, Zimmerman, Steven   +10 more
core   +4 more sources

The Effects of Angiotensin Receptor Neprilysin Inhibitor on Endoplasmic Reticulum Stress in Doxorubicin‐Mediated Cardiomyopathy‐Associated Heart Failure Model in Rats

Journal of Applied Toxicology, EarlyView.
ABSTRACT One of the most serious complications associated with the use of the chemotherapeutic agent doxorubicin (DOX) is cardiomyopathy. Although cardioprotective drugs such as angiotensin receptor‐neprilysin inhibitors (ARNI) are used to prevent cardiomyopathy in DOX patients, no studies have reported the relationship between ARNI and endoplasmic ...
Mert Unvan, Meryem İlkay Karagül, Hatice Oruç Demirbağ, Ebru Balli   +3 more
wiley   +1 more source

TRPA1 modulators in preclinical development

Expert Opinion on Therapeutic Patents, 2009
Transient receptor potential ankyrin 1 (TRPA1) has been revealed as a pivotal molecular entity in sensory biology, especially as a sensor of chemical irritants present in foods, atmospheric pollutants and neurotoxic compounds. In addition, this channel appears responsible for detecting physical signals such as noxious cold and mechanical forces.There ...
Viana, Félix, Ferrer-Montiel, Antonio
openaire   +3 more sources

Can trigeminal sensations impact saltiness perception? A mini‐review

Journal of the Science of Food and Agriculture, EarlyView.
Abstract Many food companies have begun to reduce the salt content in their products due to health concerns; however, this reduction in salt content can affect the food's sensory appeal and flavour complexity. Flavour is defined as a combination of odour (i.e., smell), taste (i.e., gustation) and trigeminal sensations (i.e., chemesthesis).
Emily Dolan, Nicoletta Faraone, Matthew B McSweeney   +2 more
wiley   +1 more source

Differential regulation of the Drosophila sleep homeostat by circadian and arousal inputs. [PDF]

, 2019
One output arm of the sleep homeostat in Drosophila appears to be a group of neurons with projections to the dorsal fan-shaped body (dFB neurons) of the central complex in the brain.
Elsheikh, Ahmed, Gurav, Adishthi S, Hackbart, Hannah, Liu, Weiwei, Montell, Craig, Ni, Jinfei D, Ogunmowo, Tyler H, Verdegaal, Andrew A   +7 more
core   +1 more source