Results 81 to 90 of about 12,428 (199)

Irritating channels: the case of TRPA1

The Journal of Physiology, 2011
Transient receptor potential (TRP) channels have been extensively studied over the past years. Yet, in most cases, the gating mechanisms of these polymodal cation channels still remain a puzzle. Using the nociceptive channel TRPA1 as an example, we discuss the role of dynamic regulation of the pore size (pore dilatation) on channel gating. Additionally,
Bernd, Nilius, Jean, Prenen, Grzegorz, Owsianik   +2 more
openaire   +3 more sources

Peripheral targets for neuropathic pain

British Journal of Pharmacology, EarlyView.
Neuropathic pain represents a significant clinical challenge, with still limited pharmacological approaches to symptomatic relief. This review focuses on molecular targets implicated in neuropathic pain, particularly those involved in peripheral mechanisms. Using the IUPHAR/BPS database of biological targets, their occurrence together with ‘neuropathic
Amirhossein Afsharipour, Cosmin I. Ciotu, Felix J. Resch, Michael J. M. Fischer   +3 more
wiley   +1 more source

Roux-en-Y gastric bypass enhances insulin secretion in type 2 diabetes via FXR-mediated TRPA1 expression

Molecular Metabolism, 2019
Objective: Roux-en-Y gastric bypass surgery (RYGB) improves the first phase of glucose-stimulated insulin secretion (GSIS) in patients with type 2 diabetes. How it does so remains unclear.
Xiangchen Kong, Yifan Tu, Bingfeng Li, Longmei Zhang, Linxian Feng, Lixiang Wang, Lin Zhang, Huarong Zhou, Xianxin Hua, Xiaosong Ma   +9 more
doaj   +1 more source

Involvement of TRPA1 Activation in Acute Pain Induced by Cadmium in Mice

Molecular Pain, 2013
Background Cadmium (Cd) is an environmental pollutant and acute exposure to it causes symptoms related to pain and inflammation in the airway and gastrointestinal tract, but the underlying mechanisms are still unclear.
Saeko Miura, Kenji Takahashi, Toshiaki Imagawa, Kunitoshi Uchida, Shigeru Saito, Makoto Tominaga, Toshio Ohta   +6 more
doaj   +1 more source

TRPA1 Ion Channel Determines Beneficial and Detrimental Effects of GYY4137 in Murine Serum-Transfer Arthritis

Frontiers in Pharmacology, 2019
Modulation of nociception and inflammation by sulfide in rheumatoid arthritis and activation of transient receptor potential ankyrin 1 (TRPA1) ion channels by sulfide compounds are well documented.
István Z. Bátai, Cecília Pápainé Sár, Ádám Horváth, Éva Borbély, Kata Bölcskei, Ágnes Kemény, Ágnes Kemény, Zoltán Sándor, Balázs Nemes, Zsuzsanna Helyes, Anikó Perkecz, Attila Mócsai, Attila Mócsai, Gábor Pozsgai, Erika Pintér   +14 more
doaj   +1 more source

Persistent in vitro nociceptor hyperexcitability and axonal retraction produced by repeated paclitaxel doses

The FEBS Journal, EarlyView.
Repeated paclitaxel exposure causes long‐lasting nociceptor hyperexcitability and axonal retraction in adult sensory neurons. Using a long‐term primary nociceptor culture, we show that hyperexcitability is mediated by sequential upregulation of NaV1.8, TRPV1, TRPA1, and TRPM8 channels.
Angela Lamberti, Victor Moreno Lozano, Asia Fernández‐Carvajal, Antonio Ferrer‐Montiel   +3 more
wiley   +1 more source

TRPA1 Ion Channel Mediates the Analgesic Effects of Acupuncture at the ST36 Acupoint in Mice Suffering from Arthritis

Journal of Inflammation Research
Kaifang Yao,1,* Zhihan Chen,1,* Yanwei Li,1 Baomin Dou,1 Zhifang Xu,1– 3 Yajing Ma,1 Simin Du,1 Jiangshan Wang,1 Jiangjiang Fu,1 Qi Liu,1 Zezhi Fan,1 Yangyang Liu,1– 3 Xiaowei Lin,1– 3 Yuan Xu,1– 3 Yuxin Fang,1– 3 Shenjun Wang,1– 3 Yi Guo1,3,4 ...
Yao K, Chen Z, Li Y, Dou B, Xu Z, Ma Y, Du S, Wang J, Fu J, Liu Q, Fan Z, Liu Y, Lin X, Xu Y, Fang Y, Wang S, Guo Y   +16 more
doaj  

Defining cellular mechanisms important for painful chemotherapy‐related neuropathy using long‐term primary cultures of nociceptors

The FEBS Journal, EarlyView.
Basic excitability alterations that drive irregular spontaneous activity in primary nociceptors during chemotherapy‐induced peripheral neuropathy. Using an in vitro model of repeated paclitaxel application to dorsal root ganglion neurons that produces progressive axonal degeneration, Lamberti and colleagues show that all three basic excitability ...
Edgar T. Walters
wiley   +1 more source

Warmth suppresses and desensitizes damage-sensing ion channel TRPA1

Molecular Pain, 2012
Background Acute or chronic tissue damage induces an inflammatory response accompanied by pain and alterations in local tissue temperature. Recent studies revealed that the transient receptor potential A1 (TRPA1) channel is activated by a wide variety of
Wang Sen, Lee Jongseok, Ro Jin Y, Chung Man-Kyo   +3 more
doaj   +1 more source

The Role of Neuropeptide Y in Dental Pulp: Balancing Neurogenic Inflammation and Pain Modulation

International Endodontic Journal, EarlyView.
ABSTRACT Background Dental pulp is a densely innervated, low‐compliance tissue in which neurogenic inflammation can rapidly escalate into oedema, raised intrapulpal pressure, microvascular compromise, and pain. While Substance P (SP) and Calcitonin gene‐related peptide (CGRP) are well‐established drivers of pulp vasodilation, the Neuroopeptide Y (NPY ...
Javier Caviedes‐Bucheli, Esteban Ulate, Hugo‐Roberto Munoz, Nestor Ríos‐Osorio   +3 more
wiley   +1 more source