Results 101 to 110 of about 23,681 (244)

Camphor Attenuates Hyperalgesia in Neuropathic Pain Models in Mice

Journal of Pain Research, 2023
Ziyuan Li,1,* Yu Gan,1,* Ting Kang,1,* Yi Zhao,1 Tianguang Huang,2 Yuhao Chen,3 Jin Liu,1 Bowen Ke1 1Department of Anesthesiology, Laboratory of Anesthesia and Critical Care Medicine, National-Local Joint Engineering Research Centre of ...
Li Z, Gan Y, Kang T, Zhao Y, Huang T, Chen Y, Liu J, Ke B   +7 more
doaj  

TRPA1 gene polymorphisms and childhood asthma. [PDF]

, 2016
BACKGROUND: Animal data have suggested that the transient receptor potential ankyrin-1 (TRPA1) ion channel plays a key role in promoting airway inflammation in asthma and may mediate effects of paracetamol on asthma, yet confirmatory human data are ...
Andre, Barnes, Barrett, Bautista, Belvisi, Bessac, Binder, Bonnelykke, Boyd, Brunekreef, Caceres, Deering-Rice, Doehring, Facchinetti, Fraser, Henderson, Hox, Jaddoe, Kang, Kim, Kruithof, Li, Lotvall, Meyers, Moffatt, Mukhopadhyay, Nassini, Nassini, Newson, Nyholt, Raemdonck, Shaheen, Siroux, Smit, Uhl, Wijga   +35 more
core   +7 more sources

High concentrations of morphine sensitize and activate mouse dorsal root ganglia via TRPV1 and TRPA1 receptors. [PDF]

, 2011
BACKGROUND: Morphine and its derivatives are key drugs in pain control. Despite its well-known analgesic properties morphine at high concentrations may be proalgesic.
Fischer, Michael JM, Forster, Alexander B, Messlinger, Karl, Reeh, Peter W   +3 more
core   +1 more source

Effectiveness and Tolerability of Topical Amitriptyline 10% Plus Lidocaine 2% Gel in Adults With Post‐Traumatic Trigeminal Neuropathic Pain: A Real‐World Evidence Study

Journal of Oral Rehabilitation, EarlyView.
A compounded amitriptyline 10% plus lidocaine 2% mucoadhesive gel was associated with substantial pain improvement and favourable tolerability in adults with post‐traumatic trigeminal neuropathic pain (PTNP). These findings support targeted mucosal delivery as a promising practical local option and a potential medication‐sparing strategy, particularly ...
Ashley Lebel, Imen Stambouli, Yves Boucher   +2 more
wiley   +1 more source

Transient activation of dopaminergic neurons during development modulates visual responsiveness, locomotion and brain activity in a dopamine ontogeny model of schizophrenia [PDF]

, 2013
It has been observed that certain developmental environmental risk factors for schizophrenia when modeled in rodents alter the trajectory of dopaminergic development, leading to persistent behavioural changes in adults. This has recently been articulated
A Gonzalo-Gomez, AH Brand, B Van Swinderen, B van Swinderen, B van Swinderen, B van Swinderen, B van Swinderen, D Eyles, D Lenz, D Tadin, DA Lewis, F Friggi-Grelin, G Gonzalez-Burgos, G Leicht, HY Chang, J van Os, J Wood, JJ McGrath, JP Wisor, K Kume, K Zhang, L Seugnet, L Shao, MJ Lundell, N Sawamura, NJ Rubinstein, O Evans, OA Masseck, OD Howes, P O’Donnell, P Seeman, P Seeman, PJ Shaw, PJ Uhlhaas, PS Goldman-Rakic, R Andretic, R Andretic, S Kapur, S Waddell, SA Hillyard, SH Fatemi, SJ Broughton, SR Pulver, T Burne, T Kitamoto, T Lebestky, TL Vickrey, TW Robbins, U Meyer, U Meyer, VS Sohal, WS Neckameyer, WS Neckameyer, X Cui, Y Ye, Z Mao   +55 more
core   +1 more source

Effects of Electroacupuncture at ST36 on Visceral Pain and Inflammatory Markers in IBS Rats

Neurogastroenterology &Motility, EarlyView.
Electroacupuncture (EA) at ST36 significantly reduced visceral pain and colonic inflammation in IBS model rats. EA increased pain thresholds, lowered AWR scores, and downregulated key inflammatory mediators (IL‐1β, IL‐6, TNF‐α, TRPV1, NF‐κB). These findings highlight ST36‐targeted EA as a promising therapeutic strategy for IBS visceral hypersensitivity
Ya‐bo Hao, Yan‐lin Liu, Xiao‐mei Wang, Kai Cheng, Qing‐yu Tu, Fei Dai, Xi‐bing Yang   +6 more
wiley   +1 more source

TRPA1: irritant detector of the airways

The Journal of Physiology, 2008
The respiratory tract is innervated by primary afferent sensory neurons that respond to mechanical and chemical stimuli (Taylor-Clark & Undem, 2006). The majority of these neurons are unmyelinated C-fibres that respond to noxious chemicals, such as reactive oxygen species (ROS), the main irritants of tear gas, air pollution and burning vegetation ...
K A, Gerhold, D M, Bautista
openaire   +3 more sources

Vascular endothelial growth factor-A165b prevents diabetic neuropathic pain and sensory neuronal degeneration [PDF]

, 2015
Diabetic peripheral neuropathy affects up to half of diabetic patients. This neuronal damage leads to sensory disturbances, including allodynia and hyperalgesia.
Arimura, Barriere, Bates, Beazley-Long, Calcutt, Calcutt, Casanova-Molla, Chattopadhyay, Chen, Chen, Christianson, Costa, David O. Bates, Deguchi, Drake, Dunham, Duran-Jimenez, Eberhardt, Eisenstein, Ferrari, Galloway, Habib, Hamilton, Hamza Riaz, Hamzeh, Hargreaves, Hulse, Ibrahim, Kamiya, Kawamura, Koivisto, Kurt Ballmer Hofer, Lin, Lucy F. Donaldson, Materazzi, McNamara, Meseguer, Motawi, Murakami, Nicholas Beazley-Long, Nikita Ved, Nowak, Obrosova, Ohta, Oltean, Pawson, Price, Priya Singhal, Quattrini, Ragavendran, Rennel, Richard P. Hulse, Ropper, Russell, Samuel M. Bestall, Schratzberger, Simard, Simon-Yarza, Simovic, Sondell, Steve J. Harper, Tomlinson, Tomlinson, Tsantoulas, Verheyen, Wei, Woolard, Xu, Zochodne   +68 more
core   +2 more sources

Integrative Phosphoproteomic Profiling Reveals Stage‐Specific Signalling and Metabolism in Equine Melanocytic Neoplasm

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT Equine melanocytic neoplasms (EMN) are aggressive tumours characterised by high metastatic potential and limited therapeutic options available. However, the molecular mechanisms underlying their progression remain poorly understood. This study therefore presents the integrative phosphoproteomic analysis of EMN tissue, with the aim of ...
Paitoon Srimontri, Amornthep Kingkaw, Nawarus Prapaiwan, Rangsima Sujittosakul, Nichapat Iamkaewprasert, Jiraschaya Piputwat, Puetta Isama‐al, Thanutchanok Munkongdee, Thanapon Chotikaprakal, Petchpailin Yanyongsirikarn, Narumon Phaonakrop, Sittiruk Roytrakul, Wanwipa Vongsangnak, Parichart Tesena   +13 more
wiley   +1 more source

Transient receptor potential ankyrin 1 (trpa1) mediates il-1β-induced apoptosis in rat chondrocytes via calcium overload and mitochondrial dysfunction

Journal of Inflammation, 2018
Background Chondrocyte apoptosis is a central feature in the progression of osteoarthritis (OA), and would be triggered by sustained elevation of intracellular calcium ion (Ca2+), also known as a cellular second messenger.
Songjiang Yin, Li Zhang, Liang Ding, Zhengquan Huang, Bo Xu, XiaoChen Li, Peimin Wang, Jun Mao   +7 more
doaj   +1 more source