Results 111 to 120 of about 13,150 (209)

Integrated O2 and H2 Gas Therapy via Microneedle‐Assisted Photocatalytic Water Splitting for Accelerating Diabetic Full‐Thickness Skin Wound Healing

Advanced Science, Volume 13, Issue 63, 12 November 2026.
A concept of integrated O2 and H2 gas therapy is achieved using a gas‐producing material. PMP nanoparticles, fabricated from platinum, MIL‐101(Fe)‐NH2, and phosphotungstic acid, are integrated into bilayer gelatin methacryloyl microneedles for transdermal delivery. These microneedles enable integrated O2 and H2 gas therapy and promote wound healing via
Zesheng Chen, Yanchao Yu, Xingyuan Xiao, Wenwen Cheng, Ye Yang, Zhengyao Zhang, Wang Wang, Zhijun Zhou, Weikang Hu, Xiaolong Wang, Bing Li, Kwang Leong Choy, Yun Chen, Zijian Wang   +13 more
wiley   +1 more source

Piezo1‐mediated unfolded protein response in goblet cells regulates intestinal mucus barrier homeostasis through the Ca2+–IRE1α–XBP1 pathway

Clinical and Translational Medicine, Volume 16, Issue 11, November 2026.
This study demonstrates that activation of Piezo1 channels in goblet cells by intestinal mechanical stimulation modulates ER calcium homeostasis via calcium ion (Ca2+) flux, which in turn regulates Mucin2 production and synthesis through the IRE1α‐XBP1. Intraperitoneal administration of Yoda1 alleviates mucus barrier impairment in DSS/WAS‐treated mice.
Jiandi Wu, Shaotong Wang, Zhe Wang, Jianhua Fang, Xueyan Li, Qingqing Zhang, Yan Dai, Wenjing Tian, Yize Ma, Gangping Li, Lei Zhang, Yudong Jiang, Xiaohua Hou, Jun Song   +13 more
wiley   +1 more source

Ruta graveolens L. in Evidence‐Based Phytotherapy: Pharmacological Activities, Bioactive Compounds and Safety

Phytotherapy Research, Volume 40, Issue 11, Page 6320-6369, November 2026.
Graphical representation of ethnomedical uses, major bioactive compounds, pharmacological potential and toxicological risks of Ruta graveolens L. ABSTRACT Ruta graveolens L. is widely used in traditional European, Asian, African, and South American medicine for digestive, nervous, cardiovascular, respiratory, and reproductive disorders.
Tetiana Serhiienko, Victoriya Georgiyants, Liudas Ivanauskas, Olha Mykhailenko   +3 more
wiley   +1 more source

Plant‐Derived Bioactives and PPAR Signaling in Functional Dyspepsia: Mechanistic Insights and Therapeutic Perspectives

Phytotherapy Research, Volume 40, Issue 11, Page 6553-6563, November 2026.
Functional dyspepsia involves duodenal barrier dysfunction, low‐grade immune activation and altered neuroimmune signalling. Various plant‐derived bioactives may modulate PPAR signalling, reduce inflammatory and oxidative stress, and support epithelial, immune, metabolic, and sensory homeostasis.
Irene Palenca, Emidio Scarpellini, Jan Tack, Pierluigi De Pierro, Giovanni Sarnelli, Giuseppe Esposito   +5 more
wiley   +1 more source

Integrated machine learning and in vitro pipeline for TRPA1-active chemesthetic flavor compounds: From predictive screening to molecular mechanisms. [PDF]

Curr Res Food Sci
Wen X, Zhang Q, Wang S, Shi Q, Wang J, Fan W, Guan S, Chai G.   +7 more
europepmc   +1 more source

TRPA1 as the Intersection of Sensory Perception, Innate Immunity, and Adaptive Immune Regulation in Cutaneous Immunity. [PDF]

Cells
Torsello A, Cattani C, Napoli C, Cavani A, Scopelliti F.   +4 more
europepmc   +1 more source

Uracil-driven ROS signaling and larval TrpA1-B neuron activation are required for priming the adult Drosophila gustatory response to bacteria. [PDF]

PLoS Biol
Milleville R, Manière G, Berthelot-Grosjean M, Lamotte O, Grosjean Y, Royet J, Kurz CL.   +6 more
europepmc   +1 more source

Resveratrol mitigates hypoxia-induced mitochondrial oxidative damage and apoptosis <i>via</i> inhibition of TRPA1 channel in retinal pigment epithelial cells. [PDF]

Int J Ophthalmol
Argun M, Nazıroğlu M.
europepmc   +1 more source

Crystal Sensing and Neurogenic Inflammation in Gout: A Proposed Sensory Neuroimmune Framework for Flare Pain. [PDF]

J Pain Res
Dong X, Xu R, Liang J, Qiu Y, Tong Y.
europepmc   +1 more source

TRPA1 blockade potentiates a ferroptosis-driven in situ vaccine nanoplatform for enhanced ROS immunotherapy against TNBC. [PDF]

Mater Today Bio
Xu X, Gao Y, Zhao R, Chen Y, Wang Z, Li Y, Wang X, Zhang P.   +7 more
europepmc   +1 more source