Results 111 to 120 of about 12,428 (199)

Chronic alcohol consumption downregulates TRPA1 ion channel and the main peptidergic messengers of the Edinger-Westphal nucleus

Scientific Reports
The urocortin 1 (UCN1) and cocaine- and amphetamine-regulated transcript (CART) co-expressing neurons of the centrally projecting Edinger-Westphal nucleus (EWcp), regulate the function of reward- and addiction-related brain areas.
Ammar Al-Omari, Izabella Török, Balázs Zoltán Zsidó, Csaba Hetényi, Erika Pintér, Zoltán Sándor, Gergely Berta, Péter Szocsics, Péter Gombás, Tünde Biró-Sütő, Balázs Gaszner, Viktória Kormos   +11 more
doaj   +1 more source

Dual role of transient receptor potential ankyrin 1 in respiratory and gastrointestinal physiology: From molecular mechanisms to therapeutic targets

Frontiers in Physiology
The transient receptor potential ankyrin 1 (TRPA1) channel plays a pivotal role in the respiratory and gastrointestinal tracts. Within the respiratory system, TRPA1 exhibits diverse distribution patterns across key cell types, including epithelial cells,
Kavya Reddy Tekulapally, Ji Yeon Lee, Dong Seop Kim, Md. Mahbubur Rahman, Chul-Kyu Park, Yong Ho Kim   +5 more
doaj   +1 more source

Could NAPQI Contribute to Paracetamol Analgesia? Redox Modulation of Kv7 Ion Channels

Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
ABSTRACT Paracetamol (acetaminophen, APAP) is one of the most widely used analgesic and antipyretic drugs worldwide, yet its mechanism of action remains incompletely understood. While several pathways have been proposed, including cyclooxygenase inhibition and endocannabinoid modulation via AM404, none fully account for its pharmacological profile. The
Sara M‐Alicante, Janire Urrutia, Arantza Muguruza‐Montero, Miren Revuelta, Ane Arrizabalaga‐Iriondo, Alvaro Villarroel, Eider Nuñez   +6 more
wiley   +1 more source

Contact sensitisers activate keratinocytes and induce cytotoxicity via Transient Receptor Potential Ankyrin 1 in allergic contact dermatitis

British Journal of Pharmacology, Volume 183, Issue 16, Page 4610-4627, August 2026.
Abstract Background and Purpose Allergic contact dermatitis (ACD) is a frequent inflammatory skin disease with limited therapeutic options. While neuronal Transient Receptor Potential Ankyrin 1 (TRPA1) has been implicated in ACD, the role of keratinocyte TRPA1 remains unclear.
Areej Jaber, Szabina Horváth, Balázs Zoltán Zsidó, Viktória Kormos, János Konkoly, Csaba Hetényi, Erika Pintér, Ágnes Kemény, Rolland Gyulai   +8 more
wiley   +1 more source

Effectiveness and Tolerability of Topical Amitriptyline 10% Plus Lidocaine 2% Gel in Adults With Post‐Traumatic Trigeminal Neuropathic Pain: A Real‐World Evidence Study

Journal of Oral Rehabilitation, Volume 53, Issue 8, Page 1550-1561, August 2026.
A compounded amitriptyline 10% plus lidocaine 2% mucoadhesive gel was associated with substantial pain improvement and favourable tolerability in adults with post‐traumatic trigeminal neuropathic pain (PTNP). These findings support targeted mucosal delivery as a promising practical local option and a potential medication‐sparing strategy, particularly ...
Ashley Lebel, Imen Stambouli, Yves Boucher   +2 more
wiley   +1 more source

Strategies for the Selection and Application of Biological Scaffolds in Organ‐on‐a‐Chip Systems

ChemBioChem, Volume 27, Issue 13, 14 July 2026.
Organ‐on‐a‐chip (OoC) serves as a promising microphysiological platform for drug screening, disease modeling, and toxicity assessment. Biomimetic scaffolds are core components that determine the performance of OoC systems by mimicking the in vivo extracellular microenvironment.
Yichi Zhang, Ning Zhang, Linkai Jiang, Zhilong Zhou, Yuwei Zhang, Yuwen Wang, Yiting Lei, Ning Hu, Zhong Alan Li   +8 more
wiley   +1 more source

Postherpetic Neuralgia: Mechanisms, Risk Factors, and Stratified Management—A Narrative Review

CNS Neuroscience &Therapeutics, Volume 32, Issue 7, July 2026.
The incidence of PHN is increasing, posing a substantial public health burden. Its pathogenesis involves VZV reactivation, peripheral and central sensitization, and genetic susceptibility, with key risk factors including older age, severe acute pain, extensive rash, immunocompromise, comorbidities, and delayed treatment.
Fei Tang, Fukun Zhao
wiley   +1 more source

Defining AV2‐1 as a novel pharmacological probe to target human and rodent TRPV2

British Journal of Pharmacology, Volume 183, Issue 13, Page 3538-3557, July 2026.
Abstract Background and Purpose Transient receptor potential vanilloid 2 (TRPV2) is a non‐selective cation channel implicated in immune cell functions. However, progress in understanding TRPV2 has been limited by a lack of potent and selective pharmacological tools, particularly those targeting the human variant. We aimed to identify and characterise a
Andrea Leipe, Julia A. Rocereta, Ruth A. Pumroy, Andreas Leffler, Michael Schaefer, Vera Moiseenkova‐Bell, Kerstin Hill   +6 more
wiley   +1 more source

Modulating Protein Function through Genetically Encoded Oxidative Chemistry. [PDF]

J Am Chem Soc
Li H, Pavlič A, Ibrahim NE, Wu D, Shapiro MG.   +4 more
europepmc   +1 more source

TRPA1 Integrates Nociceptive and Immune Signaling in <i>Hydra vulgaris</i>. [PDF]

Int J Mol Sci
D'Ezio V, Malafoglia V, Russo V, Ilari S, Proietti R, Muscoli C, Cianfanelli V, Spani F, Scalici M, Persichini T, Colasanti M.   +10 more
europepmc   +1 more source