Results 131 to 140 of about 12,878 (216)

Iso‐ and Benzisothiazolinone Inhibitors of Monoacylglycerol Lipase: Exploring On‐Target Activity Through Scaffold Decoration and In Situ Warhead Generation

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
We explore covalent allosteric targeting of MGL regulatory cysteines using iso‐ and benzisothiazolinone scaffolds. Combining mechanism‐based warhead release with structure‐guided scaffold decoration to improve molecular recognition, this study probes strategies to achieve selective on‐target engagement beyond the catalytic site. Monoacylglycerol lipase
Edoardo Rocca, Annalida Bedini, Laura Scalvini, Francesca Galvani, Riccardo Castelli, Lorenzo Sarcone, Adriano Recchia, Fabiola Fanini, Adren Tran, Silvia Rivara, Gilberto Spadoni, Daniele Piomelli, Marco Mor   +12 more
wiley   +1 more source

Relationship between sensory irritation on skin surface and TRP channel activation. [PDF]

J Physiol Sci
Fujita F, Takaishi M, Iwashita S, Yoshikawa K, Sawada M, Shimizu H, Nagamatsu M, Shiomi Y, Hara T, Ishida K, Uchida K, Suzuki Y, Tominaga M.   +12 more
europepmc   +1 more source

A TRPA1-mediated substance P release assay as an <i>in vitro</i> screening tool for airway irritant potential. [PDF]

Front Toxicol
Bedford R, Medhane R, Lawrance J, Hollings M.   +3 more
europepmc   +1 more source

TRPA1 Channels as Multimodal Environmental Sensors: Structure-Function Insights From Aquatic Organisms. [PDF]

FASEB J
He D, Li S, Zhang M, Zhan A.
europepmc   +1 more source

TRPA1 deficiency alters brown adipose tissue proteome and thermogenic gene expression during cold exposure in mice. [PDF]

Biochem Biophys Rep
Sua-Cespedes CD, Lima OG, Vasconcelos LM, Zanetti G, Avelino da Silva M, Moraes MN, Gomes G, Festuccia WT, Castrucci AML, Lacerda JT.   +9 more
europepmc   +1 more source

Evidence for Altered Epigenetic Regulatory Machinery in Migraine: A Peripheral Blood Study. [PDF]

Int J Mol Sci
Fila M, Kołacz-Milewska K, Grygiel M, Przysło L, Tworek K, Robaszkiewicz A, Ionov M, Blasiak J.   +7 more
europepmc   +1 more source

TRPA1 Gene [PDF]

, 2020
openaire   +1 more source

Gustatory function of Aedes aegypti opsins and TRPA1 in avoiding a natural insect repellent. [PDF]

Curr Biol
Chandel A, Dhavan P, Ganguly A, Singh R, Aguilar D, Lu Z, Chen Q, Montell C.   +7 more
europepmc   +1 more source

The Mitigating Effect of Remifentanil Against Sevoflurane-Induced Cardiotoxicity in Human Cardiomyocytes via TRPA1 Channels. [PDF]

J Cardiovasc Dev Dis
Aydoğan E, Övey İS, Karahan O.
europepmc   +1 more source

Context-dependent arousal via wake-promoting pontine neurons in the Drosophila melanogaster fan-shaped body. [PDF]

Sleep
Aleman A, Donlea JM.
europepmc   +1 more source