Results 131 to 140 of about 23,681 (244)

TRPA1 Ion Channel Determines Beneficial and Detrimental Effects of GYY4137 in Murine Serum-Transfer Arthritis

Frontiers in Pharmacology, 2019
Modulation of nociception and inflammation by sulfide in rheumatoid arthritis and activation of transient receptor potential ankyrin 1 (TRPA1) ion channels by sulfide compounds are well documented.
István Z. Bátai, Cecília Pápainé Sár, Ádám Horváth, Éva Borbély, Kata Bölcskei, Ágnes Kemény, Ágnes Kemény, Zoltán Sándor, Balázs Nemes, Zsuzsanna Helyes, Anikó Perkecz, Attila Mócsai, Attila Mócsai, Gábor Pozsgai, Erika Pintér   +14 more
doaj   +1 more source

Renal Disease Burden in Prurigo Nodularis: A Systematic Review and Meta‐Analysis

International Journal of Dermatology, EarlyView.
Natalia Chalupczak, Natalie Bourand, Deborah Woo, Raj Chovatiya   +3 more
wiley   +1 more source

Drafting the calmodulation playbook: Emerging structural insights into transient receptor potential channel regulation by calmodulin

The Journal of Physiology, EarlyView.
Abstract figure legend Calmodulin (CaM) is a ubiquitous calcium (Ca2+) sensor that translates intracellular Ca2+ signals into modulation of hundreds of effector proteins including ion channels. CaM is increasingly recognized as a key regulator of the transient receptor potential (TRP) channel family, yet the underlying ‘calmodulation playbook’ is only ...
Aden M. Alemayhu, Candice E. Paulsen
wiley   +1 more source

Activation of TRPA1 by membrane permeable local anesthetics

Molecular Pain, 2011
Background Low concentrations of local anesthetics (LAs) suppress cellular excitability by inhibiting voltage-gated Na+ channels. In contrast, LAs at high concentrations can be excitatory and neurotoxic. We recently demonstrated that LA-evoked activation
Kronewald Sergej, Lattrell Anja, Leffler Andreas, Niedermirtl Florian, Nau Carla   +4 more
doaj   +1 more source

Neuropeptide F regulates courtship in Drosophila through a male-specific neuronal circuit. [PDF]

, 2019
Male courtship is provoked by perception of a potential mate. In addition, the likelihood and intensity of courtship are influenced by recent mating experience, which affects sexual drive.
Aguilar, Morris A, Ganguly, Anindya, Gurav, Adishthi S, Huang, Jia, Liu, Weiwei, Montell, Craig, Ni, Jinfei D, Wang, Yijin   +7 more
core  

Conservation of Neuron‐Astrocyte Correlated Activity in Developing Sensory Pathways

Glia, Volume 74, Issue 5, May 2026.
Astrocytes and neurons in the superior colliculus exhibit spatiotemporal correlated activity before eye opening. Each neuronal wave is followed by a calcium wave in astrocytes. Spillover of glutamate activates mGluR5 and mGluR3 in astrocytes. ABSTRACT Neurons in developing sensory organs exhibit prolonged burst firing before the onset of sensory ...
Vered Kellner, Patrick Parker, Dongeun Heo, Xuelong Mi, Mikhail Coen, Guoqiang Yu, Gesine Saher, Loyal A. Goff, Dwight E. Bergles   +8 more
wiley   +1 more source

Spatial and temporal coordination of Duox/TrpA1/Dh31 and IMD pathways is required for the efficient elimination of pathogenic bacteria in the intestine of Drosophila larvae

eLife
Multiple gut antimicrobial mechanisms are coordinated in space and time to efficiently fight foodborne pathogens. In Drosophila melanogaster, production of reactive oxygen species (ROS) and antimicrobial peptides (AMPs) together with intestinal cell ...
Fatima Tleiss, Martina Montanari, Romane Milleville, Olivier Pierre, Julien Royet, Dani Osman, Armel Gallet, C Leopold Kurz   +7 more
doaj   +1 more source

Macrophage‐Targeting Biomaterials for Osteoarthritis Therapy

Journal of Biomedical Materials Research Part A, Volume 114, Issue 5, May 2026.
Macrophage‐Targeting Biomaterials for Osteoarthritis Therapy. Created in BioRender. Jain, E. (2026) https://BioRender.com/x4f9o8g. ABSTRACT Osteoarthritis (OA) is a highly prevalent, disabling, and painful disease of the joints, characterized by progressive cartilage degeneration, synovial fibrosis, and pain.
Era Jain, Paul Nana Kwame Sagoe
wiley   +1 more source

Chronic Pain: Epidemiology, Pathophysiology, and Clinical Management

MedComm, Volume 7, Issue 5, May 2026.
The multidimensional nature of chronic pain is illustrated through four interconnected domains. (Left) Epidemiology and Global Burden: Chronic pain affects approximately one in five individuals globally, contributing to a rising trend in disability‐adjusted life years (YLDs) and a significant socioeconomic impact.
Zhihao Shang, Zijiao Tian, Zhaoquan Wang, Zerui Yang, Ziyao Wang, Zikang Wang, Ziqing Wang, Xingyuan He, Yu Yan, Yuanfeng Gong, Siyuan Xu, Xinyi Li, Guihua Tian   +12 more
wiley   +1 more source

Maladaptive Inflammatory Signaling in Old Mice Impairs Colonic Regeneration by Promoting a Sustained Fetal‐Like Epithelial State

Aging Cell, Volume 25, Issue 5, May 2026.
This study explores the impact of aging on regeneration of the mouse colonic epithelium. The authors find that old mice exhibit excessive and prolonged inflammation after infection with Citrobacter, resulting in the maintenance of a fetal regenerative state in epithelial cells, insufficient tissue repair, and death of the animal.
Antonion Korcari, Helen Tauc, Jeff Duggan, Jina Yun, Fabien Wehbe, Spyros Darmanis, Zora Modrusan, Rajita Pappu, David Garfield, Heinrich Jasper, David Castillo‐Azofeifa   +10 more
wiley   +1 more source