Results 141 to 150 of about 23,681 (244)

Review Article: Targeting Peroxisome Proliferator‐Activated Receptors in Primary Biliary Cholangitis

Alimentary Pharmacology &Therapeutics, Volume 63, Issue 9, Page 1215-1235, May 2026.
Peroxisome proliferator‐activated receptor (PPAR) agonists have emerged as important second‐line treatments in primary biliary cholangitis, with profiles influenced by different selectivity for α‐, δ‐ and γ‐isoforms. PPAR‐α and PPAR‐δ agonism improve cholestasis, with inflammation reduced via all isoforms. PPAR‐δ agonism also reduces pruritus.
Jörn M. Schattenberg, Jesus M. Banales, Gideon Hirschfield, Palak Trivedi, Edward E. Cable, Charles A. McWherter, Andrew N. Billin, Daria B. Crittenden, Grant Budas   +8 more
wiley   +1 more source

Small Cell Lung Cancer Establishes a Metabolic Autocrine Mechanism Through Active Extracellular ATP Transport

Cancer Science, Volume 117, Issue 5, Page 1333-1345, May 2026.
Small cell lung cancer (SCLC) actively exports ATP through PANX1 channels, triggering P2RX7‐mediated autocrine signaling and promoting tumor proliferation. Inhibition of PANX1 or P2RX7 disrupts this loop and suppresses tumor growth. ABSTRACT Small cell lung cancer (SCLC) is an aggressive malignancy with a 5‐year survival rate of less than 7%.
Takeshi Tsuruda, Manabu Kodama, Keiichi I. Nakayama   +2 more
wiley   +1 more source

Conservation of Olfactory Avoidance in Drosophila Species and Identification of Repellents for Drosophila suzukii. [PDF]

, 2015
Flying insects use olfaction to navigate towards fruits in complex odor environments with remarkable accuracy. Some fruits change odor profiles substantially during ripening and related species can prefer different stages.
Krause Pham, Christine, Ray, Anandasankar   +1 more
core  

Animal Models of Hunner‐Type Interstitial Cystitis

International Journal of Urology, Volume 33, Issue 5, May 2026.
ABSTRACT Background Animal models are crucial for mechanistic studies and therapeutic development of human diseases. At present, the etiology of interstitial cystitis/bladder pain syndrome (IC/BPS), a chronic disease of the urinary bladder, remains undefined.
Yoshiyuki Akiyama, Yi Luo
wiley   +1 more source

The Contact Allergen Methylisothiazolinone (MIT) is a Potent Activator of the TRPA1 Ion Channel

Pharmacology Research & Perspectives
Methylisothiazolinone (MIT) is a known inducer of allergic contact dermatitis that is used as a preservative and a biocide in consumer products. Transient receptor potential ankyrin 1 (TRPA1) is a non‐selective cation channel expressed in neurons and in ...
Ilari Mäki‐Opas, Samu Luostarinen, Mari Hämäläinen, Katsuhiko Muraki, Eeva Moilanen   +4 more
doaj   +1 more source

Dual role of transient receptor potential ankyrin 1 in respiratory and gastrointestinal physiology: From molecular mechanisms to therapeutic targets

Frontiers in Physiology
The transient receptor potential ankyrin 1 (TRPA1) channel plays a pivotal role in the respiratory and gastrointestinal tracts. Within the respiratory system, TRPA1 exhibits diverse distribution patterns across key cell types, including epithelial cells,
Kavya Reddy Tekulapally, Ji Yeon Lee, Dong Seop Kim, Md. Mahbubur Rahman, Chul-Kyu Park, Yong Ho Kim   +5 more
doaj   +1 more source

TRPA1 in Inflammation

, 2016
Tulehdus on elimistön suojamekanismi ulkoisia taudinaiheuttajia vastaan. Sen tarkoituksena on poistaa uhkaava tekijä sekä palauttaa kohde-elimen ja elimistön tasapaino. Tulehdusreaktion oireita ovat punoitus, kuumotus, turvotus ja kipu. Immuunijärjestelmä pyrkii kohdentamaan tulehdusreaktion oikeisiin kohteisiin sopivissa mittasuhteissa, mutta ...
openaire   +2 more sources

Ionic Mechanisms of Spinal Neuronal Cold Hypersensitivity in Ciguatera [PDF]

, 2015
Cold hypersensitivity is evident in a range of neuropathies and can evoke sensations of paradoxical burning cold pain. Ciguatoxin poisoning is known to induce a pain syndrome caused by consumption of contaminated tropical fish that can persist for months
Brice, NL, Dickenson, AH, Lewis, RJ, Patel, R   +3 more
core  

TRPA1 Gene [PDF]

, 2020
openaire   +1 more source

Schwann Cell TRPA1, a Proalgesic Ion Channel, Mediates Neuroinflammation and Fibromyalgia-Associated Behaviours in Mice. [PDF]

J Neurochem
Brum ES, Fialho MFP, de Araújo DSM, Landini L, Marini M, De Logu F, Nassini R, Oliveira SM.   +7 more
europepmc   +1 more source