Results 21 to 30 of about 27,030 (231)

Targeting TRPV1 for Body Weight Control using TRPV1−/− Mice and Electroacupuncture [PDF]

Scientific Reports, 2015
AbstractObesity is a global social medical problem resulting in morbidity as high as 20–30%. Here we investigated whether the manipulation of TRPV1 can control mice body weight through electroacupuncture (EA). The results demonstrated that body weight increased with time in the control group (108.19 ± 1.31%, n = 7). The increase of mice body weight was
Monchanok Choowanthanapakorn, Kung-Wen Lu, Jun Yang, Ching-Liang Hsieh, Yi-Wen Lin   +4 more
openaire   +2 more sources

Monoacylglycerols Activate TRPV1 – A Link between Phospholipase C and TRPV1

PLoS ONE, 2013
Phospholipase C-mediated hydrolysis of phosphatidylinositol 4,5-bisphosphate generates diacylglycerol, inositol 1,4,5-trisphosphate and protons, all of which can regulate TRPV1 activity via different mechanisms. Here we explored the possibility that the diacylglycerol metabolites 2-arachidonoylglycerol and 1-arachidonoylglycerol, and not metabolites of
Zygmunt, Peter, Ermund, Anna, Movahed, Pouya, Andersson, David, Simonsen, Charlotte, Jönsson, Bo, Blomgren, Anders, Birnir, Bryndis, Bevan, Stuart, Eschalier, Alain, Mallet, Christophe, Gomis, Ana, Högestätt, Edward   +12 more
openaire   +8 more sources

EFFECT OF EXERCISE ON TRPV1 EXPRESSION IN THE MUSCLE OF GALUR WISTAR RATS

Jurnal Kedokteran Diponegoro
Background: Exercise is an activity that induces acid generation as one of the TRPV1 stimulants. Activation of TRPV1, a pain receptor, by acid, can lead to the formation of neuropeptides such as substance P and calcitonin gene-related peptides as a cause
Hanna Goenawan, Raisa Zahra, Putri Teesa Radhiyanti, Julia Ramadhanti, Vita Murniati Tarawan, Fifi Veronica   +5 more
doaj   +1 more source

The mechanism of heat stress-induced injury in the immature oocytes of zebrafish (Danio rerio)

The Journal of Reproduction and Development
Immature zebrafish oocytes are highly susceptible to high temperatures, making it difficult to warm cryopreserved oocytes rapidly. In the present study, we aimed to investigate whether thermosensitive channels, lipid mediators, and ferroptosis ...
Yanuar ACHADRI, Nao KUWAHARA, Momoko KIMURA, Nami KANAMARU, Kazutsugu MATSUKAWA, Keisuke EDASHIGE   +5 more
doaj   +1 more source

To not be hot when TRPV1 is not [PDF]

Temperature, 2015
Induction of hyperthermia emerged as a major side effect impeding the development of antagonists of the transient receptor potential vanilloid-1 (TRPV1) nociceptor. New ligands are now exploiting the complicated pharmacology of TRPV1 to avoid hyperthermia while insights continue to grow regarding the mechanistic basis for the action of TRPV1 ligands on
openaire   +2 more sources

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

Pressing Intervention Alleviates Pain in Rats With Myofascial Trigger Points via the TRPV1 Channel in Unmyelinated C-Type Sensory Nerve Fibers

Journal of Integrative Neuroscience
Background: Although pressing intervention is widely used clinically to alleviate pain associated with chronic myofascial trigger points (MTrPs), the mechanisms by which it modulates pain via sensory nerves remain unclear.
Yuqiao Zhang, Liya Tang, Xinyue Lv, Jiangshang Li, Fei Liu, Xiaoxia Kuang, Wu Li   +6 more
doaj   +1 more source

The Heat Sensing Trpv1 Receptor Is Not a Viable Anticonvulsant Drug Target in the Scn1a+/− Mouse Model of Dravet Syndrome

Frontiers in Pharmacology, 2021
Cannabidiol has been approved for the treatment of drug-resistant childhood epilepsies including Dravet syndrome (DS). Although the mechanism of anticonvulsant action of cannabidiol is unknown, emerging data suggests involvement of the transient receptor
Vaishali Satpute Janve, Vaishali Satpute Janve, Lyndsey L. Anderson, Lyndsey L. Anderson, Dilara Bahceci, Dilara Bahceci, Nicole A. Hawkins, Jennifer A. Kearney, Jonathon C. Arnold, Jonathon C. Arnold   +9 more
doaj   +1 more source

ROS‐Targeted Nanomotor Therapy in OA: Cartilage Protection and Pain Relief

Advanced Science, EarlyView.
ROS‐responsive NM@MET nanomotors utilize elevated ROS in osteoarthritic joints to promote deep penetration into cartilage and synovium and enable sustained metformin release. By scavenging ROS, regulating NRF2/KEAP1 signaling, protecting chondrocytes, suppressing synovial inflammation, and attenuating nociceptive signaling, NM@MET alleviates pain and ...
Meng Zheng, Changyu Liu, Qin Xia, Arndt F. Schilling, Jiawei Jiang, Renpeng Peng, Zixing Shu, Tian Ma, Danni Luo, Yaoyu Zhang, Yibo Fan, Xuyuan Zhang, Song Li, Kai Wang, Wentao Ke, Yuan Xiong, Yuanli Zhu, Fangzhi Mou, Jun Xiao, Hao Zhu   +19 more
wiley   +1 more source

Essential Oils as Modulators of TRPV1: A Scoping Review of Mechanisms and Preclinical Evidence for Natural Analgesics

Journal of Basic Medical Veterinary
Essential oils contain diverse bioactive constituents capable of modulating ion channels involved in nociception, including the transient receptor potential vanilloid 1 (TRPV1) channel. Increasing evidence suggests that these volatile compounds may exert
Chaerul Fadly Mochtar, Andini Febriyanda, Andi Ainun Zulkiah Surur, Andi Sri Dewi Anggraeni, Ulfah Widyastuti Arsal, Nana Aulia Massakuta, Nita Magfirah Ilyas, Suriati   +7 more
doaj   +1 more source