Results 21 to 30 of about 13,621 (198)

EFFECT OF EXERCISE ON TRPV1 EXPRESSION IN THE MUSCLE OF GALUR WISTAR RATS

Jurnal Kedokteran Diponegoro
Background: Exercise is an activity that induces acid generation as one of the TRPV1 stimulants. Activation of TRPV1, a pain receptor, by acid, can lead to the formation of neuropeptides such as substance P and calcitonin gene-related peptides as a cause
Hanna Goenawan, Raisa Zahra, Putri Teesa Radhiyanti, Julia Ramadhanti, Vita Murniati Tarawan, Fifi Veronica   +5 more
doaj   +1 more source

The mechanism of heat stress-induced injury in the immature oocytes of zebrafish (Danio rerio)

The Journal of Reproduction and Development
Immature zebrafish oocytes are highly susceptible to high temperatures, making it difficult to warm cryopreserved oocytes rapidly. In the present study, we aimed to investigate whether thermosensitive channels, lipid mediators, and ferroptosis ...
Yanuar ACHADRI, Nao KUWAHARA, Momoko KIMURA, Nami KANAMARU, Kazutsugu MATSUKAWA, Keisuke EDASHIGE   +5 more
doaj   +1 more source

Tumor Mechanical Remodeling via Bidirectional Calcium Redistribution Enables Deep Photothermal‐Immunotherapy

Advanced Science, EarlyView.
A bidirectional calcium‑redistributing nanomodulator rewires intra‑extracellular calcium homeostasis to remodel tumor mechanical microenvironments. It softens tumor stroma to facilitate deep tissue penetration while stiffening tumor cells, evoking amplified immunogenic cell death and robust CTL infiltration, which achieves potent deep photothermal ...
Hongjuan Zhao, Jinpei Sun, Chenxi Zhao, Yuting Cang, Keyu Zong, Yuxin Guo, Yajing Wang, Di Meng, Qingling Song, Lei Wang   +9 more
wiley   +1 more source

Pressing Intervention Alleviates Pain in Rats With Myofascial Trigger Points via the TRPV1 Channel in Unmyelinated C-Type Sensory Nerve Fibers

Journal of Integrative Neuroscience
Background: Although pressing intervention is widely used clinically to alleviate pain associated with chronic myofascial trigger points (MTrPs), the mechanisms by which it modulates pain via sensory nerves remain unclear.
Yuqiao Zhang, Liya Tang, Xinyue Lv, Jiangshang Li, Fei Liu, Xiaoxia Kuang, Wu Li   +6 more
doaj   +1 more source

An Extracellular Pore‑Targeting Peptide Defines a Designable Allosteric Site in TRPV2

Advanced Science, EarlyView.
Structure‐guided peptide engineering yields Depiv2, a highly potent and subtype‐selective TRPV2 inhibitor that binds to the extracellular pore and remodels it into a closed, non‐conductive state. Depiv2 suppresses pathological cardiac hypertrophy, establishing the TRPV2 outer pore as a designable interface for selective peptide modulation.
Aiqin Zhu, Hongkun Wang, Jiawei Wang, Xiaolu Liu, Aerziguli Aierken, Lizhen Xu, Ping Liang, Fan Yang   +7 more
wiley   +1 more source

Essential Oils as Modulators of TRPV1: A Scoping Review of Mechanisms and Preclinical Evidence for Natural Analgesics

Journal of Basic Medical Veterinary
Essential oils contain diverse bioactive constituents capable of modulating ion channels involved in nociception, including the transient receptor potential vanilloid 1 (TRPV1) channel. Increasing evidence suggests that these volatile compounds may exert
Chaerul Fadly Mochtar, Andini Febriyanda, Andi Ainun Zulkiah Surur, Andi Sri Dewi Anggraeni, Ulfah Widyastuti Arsal, Nana Aulia Massakuta, Nita Magfirah Ilyas, Suriati   +7 more
doaj   +1 more source

The Heat Sensing Trpv1 Receptor Is Not a Viable Anticonvulsant Drug Target in the Scn1a+/− Mouse Model of Dravet Syndrome

Frontiers in Pharmacology, 2021
Cannabidiol has been approved for the treatment of drug-resistant childhood epilepsies including Dravet syndrome (DS). Although the mechanism of anticonvulsant action of cannabidiol is unknown, emerging data suggests involvement of the transient receptor
Vaishali Satpute Janve, Vaishali Satpute Janve, Lyndsey L. Anderson, Lyndsey L. Anderson, Dilara Bahceci, Dilara Bahceci, Nicole A. Hawkins, Jennifer A. Kearney, Jonathon C. Arnold, Jonathon C. Arnold   +9 more
doaj   +1 more source

Cannabinoid CB1 Receptor in Nociceptors Mediates Postoperative Analgesia via ASIC3 Inhibition

Advanced Science, EarlyView.
CB1R and ASIC3 are co‐expressed in CGRP+ nociceptors of mouse DRG. Plantar incision triggers an upregulation of ASIC3 and activation of ASIC3+ neurons, driving mechanical allodynia. CB1R activation suppresses ASIC3 function and downstream ERK1/2 phosphorylation, thereby braking nociceptive signaling and accelerating pain resolution.
Kangtai Xu, Luyao Ji, Haoyi Yang, Xiying Chen, Qiaodan Hu, Haimei He, Jiawei Wu, Leyan Shan, Shihui Feng, Yingzhi Li, Xiongchang Tan, Hao Wang, Zilong Wang, Chaoran Wu   +13 more
wiley   +1 more source

Bibliometric Analysis of Global Research on Transient Receptor Potential Vanilloid 1 in the Field of Pain

Journal of Pain Research, 2023
Sisi Wang,1 Wen Wang,2 Xiangming Ye1 1Center for Rehabilitation Medicine, Rehabilitation & Sports Medicine Research Institute of Zhejiang Province, Department of Rehabilitation Medicine, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital,
Wang S, Wang W, Ye X
doaj  

Maximal transient receptor potential vanilloid 1 (TRPV1) immunoreactivity is seen in the keratinocytes of the suprabasal layer of the epidermis

, 2011
Copyright information:Taken from "Epidermal transient receptor potential vanilloid 1 in idiopathic small nerve fibre disease, diabetic neuropathy and healthy human subjects"Histopathology 2007;51(5):674-680.Published online Jan 2007PMCID:PMC2121152 ...
Y Guo (82682), E P Wilder-Smith (82680), W-Y Ong (82681), A W-L Chow (82683)   +3 more
core   +1 more source