Results 21 to 30 of about 26,834 (239)
Gut Microbes, 2021 Ferroptosis, a new type of cell death has been found to aggravate intestinal ischemia/reperfusion (I/R) injury. However, little is known about the changes of gut microbiota and metabolites in intestinal I/R and the role of gut microbiota metabolites on ...
Fan Deng +10 more
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Thorax, 2004 Iodo-resiniferatoxin, a new TRPV1 inhibitor, shows promising antitussive activity in an animal model Cough is one of the most common respiratory complaints and intractable cough remains one of the most distressing and difficult to treat conditions of the lung.
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Urothelial TRPV1: TRPV1-Reporter Mice, a Way to Clarify the Debate? [PDF]
Frontiers in Physiology, 2012 The urothelium is a complex and dynamic epithelial layer with a sensory role contributing to mechano- and chemosensation in the bladder. This primary source of sensory inputs modulates micturition via an urothelial–sensory fibers crosstalk. The communication is mediated by ATP and NO release from epithelial cells.
Mathieu eBoudes +2 more
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Targeting TRPV1 for Body Weight Control using TRPV1−/− Mice and Electroacupuncture [PDF]
Scientific Reports, 2015 AbstractObesity is a global social medical problem resulting in morbidity as high as 20–30%. Here we investigated whether the manipulation of TRPV1 can control mice body weight through electroacupuncture (EA). The results demonstrated that body weight increased with time in the control group (108.19 ± 1.31%, n = 7). The increase of mice body weight was
Monchanok Choowanthanapakorn +4 more
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Acupoint Catgut Embedding Diminishes Fibromyalgia Pain through TRPV1 in the Mouse Brain
Journal of Integrative Neuroscience, 2023 Background: Chronic pain refers to pain that persists for over three months. Chronic pain may restrict activities of daily living, including work, learning, social life, and can lead to anxiety, depression, and sleep disturbance.
Po-Chih Lai +4 more
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Journal of Pain Research, 2023 Christie RA Leite-Panissi,1 Bruna B De Paula,2 John K Neubert,3 Robert M Caudle2 1Department of Psychology, School of Philosophy, Science and Literature of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil; 2Department of Oral and ...
Leite-Panissi CR +3 more
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Frontiers in Bioscience-Landmark, 2021 Tetrahydropalmatine (dl-THP) demonstrates an analgesic effect in animal models of neuropathic and inflammatory pain, however, the underlying mechanisms of its pharmacological action within the spinal cord remains unclear. Both P2X3 receptor and TRPV1 are
Yan Wang +8 more
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Animals, 2020 Joint pain and osteoarthritis (OA) are some of the most common causes of lameness in horses, and most of the available treatments focus on symptomatic relief without a disease-modifying effect.
Anne Frank Gallagher vom Braucke +6 more
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Journal of the International Society of Sports Nutrition, 2023 Background The aim of this study was to explore the effects of a low dose (LD) of 0.625 mg and a high dose (HD) of 2.5 mg of phenylcapsaicin (PC) on full squat (SQ) performance, active muscle (RPE-AM) and overall body (RPE-OB) ratings of perceived ...
Pablo Jiménez-Martínez +7 more
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Monoacylglycerols Activate TRPV1 – A Link between Phospholipase C and TRPV1
PLoS ONE, 2013 Phospholipase C-mediated hydrolysis of phosphatidylinositol 4,5-bisphosphate generates diacylglycerol, inositol 1,4,5-trisphosphate and protons, all of which can regulate TRPV1 activity via different mechanisms. Here we explored the possibility that the diacylglycerol metabolites 2-arachidonoylglycerol and 1-arachidonoylglycerol, and not metabolites of
Zygmunt, Peter +12 more
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