Results 31 to 40 of about 26,834 (239)

The role of TRPV1 channels in atherosclerosis [PDF]

Channels, 2020
Transient receptor potential vanilloid subfamily member 1 (TRPV1) is a nonselective cation channel, that is mainly distributed in sensory nerve endings and can release a variety of neurotransmitters after activation. Early studies showed that it mainly conducts pain sensation, but research has demonstrated that it also plays an important role in ...
Chenyang Zhang, Lifang Ye, Qinggang Zhang, Fei Wu, Lihong Wang   +4 more
openaire   +2 more sources

To not be hot when TRPV1 is not [PDF]

Temperature, 2015
Induction of hyperthermia emerged as a major side effect impeding the development of antagonists of the transient receptor potential vanilloid-1 (TRPV1) nociceptor. New ligands are now exploiting the complicated pharmacology of TRPV1 to avoid hyperthermia while insights continue to grow regarding the mechanistic basis for the action of TRPV1 ligands on
openaire   +2 more sources

Contributions of Different Modes of TRPV1 Activation to TRPV1 Antagonist-Induced Hyperthermia [PDF]

The Journal of Neuroscience, 2010
Transient receptor potential vanilloid-1 (TRPV1) antagonists are widely viewed as next-generation pain therapeutics. However, these compounds cause hyperthermia, a serious side effect. TRPV1 antagonists differentially block three modes of TRPV1 activation: by heat, protons, and chemical ligands (e.g., capsaicin).
Andras, Garami, Yury P, Shimansky, Eszter, Pakai, Daniela L, Oliveira, Narender R, Gavva, Andrej A, Romanovsky   +5 more
openaire   +2 more sources

Dual Regulation of TRPV1 by Phosphoinositides [PDF]

Journal of Neuroscience, 2007
The membrane phospholipid phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P2 or PIP2] regulates many ion channels. There are conflicting reports on the effect of PtdIns(4,5)P2 on transient receptor potential vanilloid 1 (TRPV1) channels. We show that in excised patches PtdIns(4,5)P2 and other phosphoinositides activate and the PIP2 scavenger poly-Lys
Viktor, Lukacs, Baskaran, Thyagarajan, Peter, Varnai, Andras, Balla, Tamas, Balla, Tibor, Rohacs   +5 more
openaire   +2 more sources

EFFECT OF EXERCISE ON TRPV1 EXPRESSION IN THE MUSCLE OF GALUR WISTAR RATS

Jurnal Kedokteran Diponegoro
Background: Exercise is an activity that induces acid generation as one of the TRPV1 stimulants. Activation of TRPV1, a pain receptor, by acid, can lead to the formation of neuropeptides such as substance P and calcitonin gene-related peptides as a cause
Hanna Goenawan, Raisa Zahra, Putri Teesa Radhiyanti, Julia Ramadhanti, Vita Murniati Tarawan, Fifi Veronica   +5 more
doaj   +1 more source

Dissecting TRPV1: Lessons to be learned? [PDF]

Channels, 2011
The transient receptor potential channel TRPV1 is a polymodal nociceptor. It is primarily expressed in dorsal root ganglia and peripheral sensory nerve endings, and to a much lesser extent, in the central nervous system. It has also been implicated in the functional properties of e.g. urinary and bronchial epithelia. TRPV1 has long been under intensive
Christian, Grimm, Eduardo, Aneiros, Marcel, de Groot   +2 more
openaire   +2 more sources

The mechanism of heat stress-induced injury in the immature oocytes of zebrafish (Danio rerio)

The Journal of Reproduction and Development
Immature zebrafish oocytes are highly susceptible to high temperatures, making it difficult to warm cryopreserved oocytes rapidly. In the present study, we aimed to investigate whether thermosensitive channels, lipid mediators, and ferroptosis ...
Yanuar ACHADRI, Nao KUWAHARA, Momoko KIMURA, Nami KANAMARU, Kazutsugu MATSUKAWA, Keisuke EDASHIGE   +5 more
doaj   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Pressing Intervention Alleviates Pain in Rats With Myofascial Trigger Points via the TRPV1 Channel in Unmyelinated C-Type Sensory Nerve Fibers

Journal of Integrative Neuroscience
Background: Although pressing intervention is widely used clinically to alleviate pain associated with chronic myofascial trigger points (MTrPs), the mechanisms by which it modulates pain via sensory nerves remain unclear.
Yuqiao Zhang, Liya Tang, Xinyue Lv, Jiangshang Li, Fei Liu, Xiaoxia Kuang, Wu Li   +6 more
doaj   +1 more source

The Heat Sensing Trpv1 Receptor Is Not a Viable Anticonvulsant Drug Target in the Scn1a+/− Mouse Model of Dravet Syndrome

Frontiers in Pharmacology, 2021
Cannabidiol has been approved for the treatment of drug-resistant childhood epilepsies including Dravet syndrome (DS). Although the mechanism of anticonvulsant action of cannabidiol is unknown, emerging data suggests involvement of the transient receptor
Vaishali Satpute Janve, Vaishali Satpute Janve, Lyndsey L. Anderson, Lyndsey L. Anderson, Dilara Bahceci, Dilara Bahceci, Nicole A. Hawkins, Jennifer A. Kearney, Jonathon C. Arnold, Jonathon C. Arnold   +9 more
doaj   +1 more source