Results 51 to 60 of about 37,042 (291)

Loss of SHP1 in Spinal Astrocytes Triggers T‐Lymphocyte Infiltration and Nociceptive Hypersensitivity

Advanced Science, EarlyView.
Astrocyte‐specific SHP1 deletion disrupts astrocyte–vascular interactions and compromises BBB integrity while enhancing STAT1‐dependent CXCL10 expression. These changes synergistically promote peripheral CD4+ and CD8+ T‐cell infiltration into the SDH. The infiltrating T cells secrete IFN‐γ, which in turn activates microglia.
Lan‐Xing Yi, Lin Yang, Kang‐Li Wang, Hui‐Zhu Liu, Rui‐Ying Chen, Min Su, Xiao Xiao, Yu‐Qiu Zhang   +7 more
wiley   +1 more source

The Association Between Long-Term Spicy-Food Consumption and the Incidence of Chronic Postsurgical Pain After Cesarean Delivery: An Observational Study

Journal of Pain Research, 2022
Zhuoxi Wu,1,* Mi Yang,1,* Peng Zhao,1,2 Feng Zou,1 Jing Peng,1 Qiangting Deng,3 Guangyou Duan,4,* Hong Li1,* 1Department of Anesthesiology, Second Affiliated Hospital of Army Medical University, People’s Liberation Army of China ...
Wu Z, Yang M, Zhao P, Zou F, Peng J, Deng Q, Duan G, Li H   +7 more
doaj  

TRPV1 activation and internalization is part of the LPS-induced inflammation in human iPSC-derived cardiomyocytes

Scientific Reports, 2021
The non-selective cation channel transient receptor potential vanilloid 1 (TRPV1) is expressed throughout the cardiovascular system. Recent evidence shows a role for TRPV1 in inflammatory processes.
Katherine Sattler, Ibrahim El-Battrawy, Lukas Cyganek, Siegfried Lang, Huan Lan, Xin Li, Zhihan Zhao, Jochen Utikal, Thomas Wieland, Martin Borggrefe, Xiaobo Zhou, Ibrahim Akin   +11 more
doaj   +1 more source

The role of The TRPV1 receptor in vascularity

, 2022
This thesis describes the role of the trpv1 receptor in vascularity, research has shown that it has a mixed vasodilatory and vasoconstrictor effect.
Abdallah, Ahmed Ayman Mohammed Aly
core  

Maximal transient receptor potential vanilloid 1 (TRPV1) immunoreactivity is seen in the keratinocytes of the suprabasal layer of the epidermis

, 2011
Copyright information:Taken from "Epidermal transient receptor potential vanilloid 1 in idiopathic small nerve fibre disease, diabetic neuropathy and healthy human subjects"Histopathology 2007;51(5):674-680.Published online Jan 2007PMCID:PMC2121152 ...
Y Guo (82682), E P Wilder-Smith (82680), W-Y Ong (82681), A W-L Chow (82683)   +3 more
core   +1 more source

Identification of TRPV1 ion channels agonists in Tropaeolum tuberosum

, 2020
Tropaeolum tuberosum, commonly known as Mashua, is an herbal remedy used in traditional Andean medicine (Peruvian-Bolivian) for the relief of kidney and bladder pain, as well as contusions.
Palomino Ruiz-Poveda, Olga María, Thiebaut Estrada, Cristina, Rumbero Sánchez, Angel, Apaza Ticona, Luis Nestor   +3 more
core   +1 more source

An Innervated Human Skin Equivalent that Electrically Encodes Mechanical and Thermal Stimuli

Advanced Science, EarlyView.
An innervated human skin equivalent is integrated with high‐density microelectrode arrays to reveal how engineered free nerve ending–like structures translate touch and temperature into electrical codes. Mechanical indentation and thermal stimulation engage the engineered somatosensory circuitry and evoke distinct firing and waveform signatures ...
Daniele Bellantoni, Costantino Casale, Marika Sperduti, Nevio L. Tagliamonte, Giorgia Imparato, Loredana Zollo, Paolo A. Netti   +6 more
wiley   +1 more source

Participação dos receptores CXCR2 e TRPV1 na cistite induzida por ciclofosfamida em ratos [PDF]

, 2013
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Farmacologia, Florianópolis, 2013.A proposta do presente estudo foi avaliar a participação dos receptores CXCR2 e TRPV1 na cistite ...
Dornelles, Fabiana Noronha
core  

Contributions of Different Modes of TRPV1 Activation to TRPV1 Antagonist-Induced Hyperthermia [PDF]

The Journal of Neuroscience, 2010
Transient receptor potential vanilloid-1 (TRPV1) antagonists are widely viewed as next-generation pain therapeutics. However, these compounds cause hyperthermia, a serious side effect. TRPV1 antagonists differentially block three modes of TRPV1 activation: by heat, protons, and chemical ligands (e.g., capsaicin).
Andras, Garami, Yury P, Shimansky, Eszter, Pakai, Daniela L, Oliveira, Narender R, Gavva, Andrej A, Romanovsky   +5 more
openaire   +2 more sources

Tumor Mechanical Remodeling via Bidirectional Calcium Redistribution Enables Deep Photothermal‐Immunotherapy

Advanced Science, EarlyView.
A bidirectional calcium‑redistributing nanomodulator rewires intra‑extracellular calcium homeostasis to remodel tumor mechanical microenvironments. It softens tumor stroma to facilitate deep tissue penetration while stiffening tumor cells, evoking amplified immunogenic cell death and robust CTL infiltration, which achieves potent deep photothermal ...
Hongjuan Zhao, Jinpei Sun, Chenxi Zhao, Yuting Cang, Keyu Zong, Yuxin Guo, Yajing Wang, Di Meng, Qingling Song, Lei Wang   +9 more
wiley   +1 more source