Results 51 to 60 of about 26,834 (239)

Toward Chromoselective Transformations in Biological Systems: Perspectives and Challenges

Angewandte Chemie International Edition, EarlyView.
Controlling biological systems with small‐molecule chromophores has evolved into a powerful strategy and is applied from chemical biology to medicine. However, the complexity of in vivo systems cannot be matched by a single wavelength of light. Developing methods to combine and individually control multiple chromophores is crucial.
Nadja A. Simeth
wiley   +1 more source

Diverse TRPV1 responses to cannabinoids [PDF]

Channels, 2019
Cannabinoid compounds are potential analgesics. Users of medicinal Cannabis report efficacy for pain control, clinical studies show that cannabis can be effective and opioid sparing in chronic pain, and some constituent cannabinoids have been shown to target nociceptive ion channels. Here, we explore and compare a suite of cannabinoids for their impact
J. Starkus, C. Jansen, L. M. N. Shimoda, A. J. Stokes, A. L. Small-Howard, H. Turner   +5 more
openaire   +2 more sources

Comprehensive Characterization of Acer truncatum Leaf Extract: Identification of Systemic Metabolites and Effects on Performance, Antioxidant Status, and Intestinal Microbiota in Laying Hens

Animal Research and One Health, EarlyView.
Dietary A. truncatum leaf extract is absorbed and improves laying performance in aged hens by enhancing systemic antioxidant capacity and modulating the gut microbiota. ABSTRACT The demand for natural feed additives is considerably increasing in the antibiotic‐free feed era.
Kailong Qin, Jiantao Yang, Minglu Gao, Xiaozhao Tao, Xin Yang, Yanli Liu, Xiaojun Yang   +6 more
wiley   +1 more source

Capsaicin: beyond TRPV1

Frontiers in Nutrition
Capsaicin, the chili-pungent compound, has a peculiar chemical structure that allows it to impact mammalian physiology. Besides its classical effects through activating the Transient Receptor Potential Vanilloid type 1 (TRPV1), growing experimental evidence demonstrates that capsaicin has pleiotropic actions in a TRPV1-independent manner. These effects
Rebeca Juárez-Contreras, Rebeca Juárez-Contreras, Edgardo Mota-Carrillo, Edgardo Mota-Carrillo, Angelica Piedra-Ramírez, Angelica Piedra-Ramírez, Daniel Farías-Sánchez, Daniel Farías-Sánchez, Ricardo González-Ramírez, Ricardo González-Ramírez, Sara Luz Morales-Lázaro, Sara Luz Morales-Lázaro   +11 more
openaire   +3 more sources

Myrcene and terpene regulation of TRPV1 [PDF]

Channels, 2019
Nociceptive Transient Receptor Potential channels such as TRPV1 are targets for treating pain. Both antagonism and agonism of TRP channels can promote analgesia, through inactivation and chronic desensitization. Since plant-derived mixtures of cannabinoids and the Cannabis component myrcene have been suggested as pain therapeutics, we screened terpenes
C. Jansen, L.M.N Shimoda, J.K. Kawakami, L. Ang, A.J. Bacani, J.D. Baker, C. Badowski, M. Speck, A.J. Stokes, A.L. Small-Howard, H Turner   +10 more
openaire   +2 more sources

Fiber‐type soft bioelectronics for wearable and implantable sensing and therapy

BMEMat, EarlyView.
Fiber‐type soft bioelectronics are emerging as versatile platforms for wearable and implantable health monitoring and therapeutic applications. These bioelectronics use organic and inorganic matrices combined with advanced fillers, which feature high conductivity, electrochemical sensitivity, softness, and biocompatibility.
Haneul Kim, Hak Yong Kim, Ja Hoon Koo, Gi Doo Cha, Dae‐Hyeong Kim, Hye Jin Kim   +5 more
wiley   +1 more source

Central Sensitization-Related Changes in Brain Function Activity in a Rat Endometriosis-Associated Pain Model [Corrigendum]

Journal of Pain Research, 2020
Zheng P, Jia S, Guo D, et al. J Pain Res. 2020;13:95–107.During the final editing stages of manuscript preparation, the authors mistakenly repeated the Pain Cg1 and Tha images used in Figure 6 on page 103.
Zheng P, Jia S, Guo D, Chen S, Zhang W, Cheng A, Xie W, Sun G, Leng J, Lang J   +9 more
doaj  

Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases

BMEMat, EarlyView.
This review highlights the immunomodulatory potential of nanomaterials (NMs) in treating neurodegenerative diseases (NDs). It focuses on their roles in regulating innate and adaptive immune responses to maintain immune homeostasis. By providing insights into these mechanisms, the review lays the groundwork for innovative NMs therapeutic strategies to ...
Xinru Zhou, Jia Liu, Shulin Lai, Suhan Yin, Bingmin Luo, Longquan Shao, Yiyuan Kang   +6 more
wiley   +1 more source

Targeting neutrophil extracellular traps in metabolic and immune niche: Nanomaterials for diabetes tissue regeneration

BMEMat, EarlyView.
The effects of NETs on regeneration of various diabetic tissues, and strategies targeting NETs for diabetes tissue regeneration. In the diabetic environment, NETs undergo complex metabolic and immune reprogramming, leading to dynamic changes in antibacterial and proinflammatory functions, and affecting regeneration of multiple systemic tissues.
Xinyi Jiang, Muxin Yue, Kai Mao, Boon Chin Heng, Noor Azlin Yahya, Yunsong Liu, Zheng Li   +6 more
wiley   +1 more source

Cannabidiol as a Novel Therapeutic for Immune Modulation

ImmunoTargets and Therapy, 2020
Nadia Peyravian,1,2 Sapna Deo,1,2 Sylvia Daunert,1– 3 Joaquin J Jimenez1,2,4 1Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL, USA; 2Dr.
Peyravian N, Deo S, Daunert S, Jimenez JJ   +3 more
doaj