Results 71 to 80 of about 37,042 (291)
BMEMat, EarlyView.The effects of NETs on regeneration of various diabetic tissues, and strategies targeting NETs for diabetes tissue regeneration. In the diabetic environment, NETs undergo complex metabolic and immune reprogramming, leading to dynamic changes in antibacterial and proinflammatory functions, and affecting regeneration of multiple systemic tissues.
Xinyi Jiang +6 more
wiley +1 more source
Optical control of TRPV1 channels in vitro with tethered photopharmacology [PDF]
Transient receptor potential vanilloid 1 (TRPV1) is a nonselective cation channel that is important for nociception and inflammatory pain, and is activated by a variety of nociceptive stimuli—including lipids such as capsaicin (CAP) and endocannabinoids.
James, Frank +2 more
core +2 more sources
Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges
BMEMat, EarlyView.This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma +8 more
wiley +1 more source
Emodin Down-Regulates Expression of TRPV1 mRNA and Its Function in DRG Neurons in Vitro [PDF]
, 2010 Emodin is a principle ingredient isolated from rhubarb rhizome, which is commonly used for constipation or pain-related diseases in traditional Chinese medicine (TCM) practice. The transient receptor potential vanilloid 1 ion channel proteins (TRPV1) are
Zhao, Bao-Sheng +11 more
core +1 more source
Peripheral and central mechanisms in acid induced visceral pain hypersensitivity in the human oesophagus [PDF]
, 2010 PhDIntroduction: Gastro-oesophageal reflux disease (GORD) affects 40% of Western populations. Many symptoms persist despite the resolution of inflammation or acid exposure.
Chua, Yang Chong
core +3 more sources
Drug Design, Development and Therapy, 2021 Qudong Lu,1 Yang Yang,1 Hengshuai Zhang,1 Cheng Chen,2 Jiang Zhao,1 Zhenxing Yang,1 Yi Fan,1 Longkun Li,1 Huan Feng,1 Jingzhen Zhu,1 Shanhong Yi1 1Department of Urology, Second Affiliated Hospital, Army Medical University, Chongqing, 400037, People’s ...
Lu Q +10 more
doaj
PILOT STUDY OF THE ASSOCIATION OF TRPA1 AND TRPV1 GENE POLYMORPHISMS WITH MYOCARDIAL INFARCTION
Атеросклероз, 2019 The aim of the study was to investigate the association of SNPs in the TRPA1 (rs13268757) and TRPV1 (rs222747) genes with myocardial infarction. Material and methods.
P. S. Orlov +5 more
doaj +1 more source
The genetic architecture of epilepsy across molecular mechanisms and clinical heterogeneity
Epilepsia Open, EarlyView.Abstract Epilepsy comprises a highly heterogeneous group of neurological disorders unified by a persistent predisposition to recurrent seizures, yet driven by remarkably diverse genetic, molecular, and network‐level mechanisms. Advances in genomic technologies have revealed that epilepsy arises from a multilayered genetic architecture encompassing rare
Mohammad Reza Seyedtaghia +4 more
wiley +1 more source
Exploration, EarlyView.This review highlights recent advances in engineering messenger RNA (mRNA)‐lipid nanoparticles (LNPs) to cross the ageing blood–brain barrier and target neurodegenerative diseases. It outlines design principles, delivery routes, and translational challenges, charting a roadmap towards clinical application of mRNA‐LNP therapeutics for neurodegenerative ...
Abdel Ali Belaidi +5 more
wiley +1 more source
Journal of Pain Research, 2020 Ping Zheng, 1 Shuangzheng Jia, 1 Dalong Guo, 2 Sikai Chen, 1 Wen Zhang, 1 Aoshuang Cheng, 1 Weijie Xie, 3 Guibo Sun, 3 Jinhua Leng, 1 Jinghe Lang 1 1Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of ...
Zheng P +9 more
doaj