Results 71 to 80 of about 13,621 (198)

Artificial Intelligence‐Driven Natural Product Drug Discovery: From Computational Genome Mining to Clinical Translation

Medicinal Research Reviews, EarlyView.
ABSTRACT Natural products (NPs) have historically yielded numerous therapeutic agents, yet their integration into modern drug discovery has been constrained by chemical complexity, low abundance, laborious dereplication, and limited target annotation.
Antonio Lavecchia
wiley   +1 more source

Comparison of TRPV1 and TRPV1/mSlo1 currents.

, 2013
A, The time coruse of the TRPV1 currents. The TRPV1 currents, expressed in HEK293 cells, were recorded with repetitive voltage steps from -60 to 0 mV with a time interval of 2 seconds, before, during, and after the application of 5 μM Capsaicin as ...
Ying Wu (19057), Beiying Liu (471709), Feng Qin (133395), Wenjuan Kong (471708), Yuexuan Zhang (471710), Yongfeng Liu (413340), Panpan Hou (471706), Jing Yao (169854), Zonghe Yan (471707), Jiuping Ding (45929), Xia Li (14984)   +10 more
core   +1 more source

Repurposing antimicrobial agents for neuroprotection: Mechanisms, clinical potential, and challenges

Neuroprotection, EarlyView.
Antimicrobial agents exert neuroprotective effects through modulation of interconnected pathways. Tetracyclines, macrolides, antimalarial agents, sulfones, and antiparasitic agents suppress neuroinflammation, oxidative stress, and apoptosis while preserving mitochondrial function and neurotransmission.
Mohammad Amin Manavi, Mohammadreza Salehi, Razieh Mohammad Jafari, Ramin Goudarzi, Saman Khosravi, Ahmad Reza Dehpour   +5 more
wiley   +1 more source

Multitarget Regulatory Mechanisms and Research Advances of Plant‐Derived Bioactive Ingredients in Hypertension Prevention and Management

Phytotherapy Research, EarlyView.
Schematic overview of the multi‐target and multi‐pathway mechanisms of PDBI in the prevention and management of hypertension. ABSTRACT Hypertension remains a major global risk factor for cardiovascular diseases, yet current treatments face challenges such as suboptimal blood pressure control and inadequate organ protection.
Qiqi Deng, Yonglin Zhang, Jing Pan, Jing Luo, Hualin Sun, Chaonian Li, Li Li   +6 more
wiley   +1 more source

A New Perspective on the Prevention and Treatment of Knee Osteoarthritis: the Mechanism and Intervention Strategy of TRPV1

Xiehe Yixue Zazhi
Transient receptor potential vanilloid 1 is a non-selective cation channel, which is sensitive to heat, acidic environment and capsaicin. It is widely expressed in sensory neurons and various other tissues, and is closely associated with the development ...
SHAO Hong, ZHAO Jirong, LI Xixiang, HUANG Qingjie, CHEN Qiqing   +4 more
doaj   +1 more source

Ruta graveolens L. in Evidence‐Based Phytotherapy: Pharmacological Activities, Bioactive Compounds and Safety

Phytotherapy Research, EarlyView.
Graphical representation of ethnomedical uses, major bioactive compounds, pharmacological potential and toxicological risks of Ruta graveolens L. ABSTRACT Ruta graveolens L. is widely used in traditional European, Asian, African, and South American medicine for digestive, nervous, cardiovascular, respiratory, and reproductive disorders.
Tetiana Serhiienko, Victoriya Georgiyants, Liudas Ivanauskas, Olha Mykhailenko   +3 more
wiley   +1 more source

Plant‐Derived Bioactives and PPAR Signaling in Functional Dyspepsia: Mechanistic Insights and Therapeutic Perspectives

Phytotherapy Research, EarlyView.
Functional dyspepsia involves duodenal barrier dysfunction, low‐grade immune activation and altered neuroimmune signalling. Various plant‐derived bioactives may modulate PPAR signalling, reduce inflammatory and oxidative stress, and support epithelial, immune, metabolic, and sensory homeostasis.
Irene Palenca, Emidio Scarpellini, Jan Tack, Pierluigi De Pierro, Giovanni Sarnelli, Giuseppe Esposito   +5 more
wiley   +1 more source

Monoacylglycerols Activate TRPV1-A Link between Phospholipase C and TRPV1 [PDF]

, 2013
Phospholipase C-mediated hydrolysis of phosphatidylinositol 4,5-bisphosphate generates diacylglycerol, inositol 1,4,5-trisphosphate and protons, all of which can regulate TRPV1 activity via different mechanisms.
Andersson, David A, Peter M. Zygmunt (241661), Bryndis Birnir (113570), Alain Eschalier (209750), Stuart Bevan (303154), Pouya Movahed, Edward D. Högestätt (241662), Charlotte Simonsen (441655), Zygmunt, Peter M, Andersson, David A., Bevan, Stuart, Andersson, David, Jonsson, Bo A. G., Anna Ermund (241659), Jönsson, Bo, a G, Blomgren, Anders, Eschalier, Alain, Zygmunt, Peter M., Movahed, Pouya, Simonsen, Charlotte, Mallet, Christophe, Högestätt, Edward, D, Ana Gomis (491626), Bo A G Jönsson, Anders Blomgren, Gomis, Ana, Jönsson, Bo A G, Birnir, Bryndis, Christophe Mallet, Edward D Högestätt, Anna Ermund, Pouya Movahed (491625), David A. Andersson (303152), Jönsson, Bo A, Peter M Zygmunt, Anders Blomgren (441654), Högestätt, Edward D, Zygmunt, Peter, Bo A. G. Jönsson (241660), Charlotte Simonsen, Alain Eschalier, David A Andersson, Stuart Bevan, Bevan, Stuart; id_orcid, Andersson, David, A, Ermund, Anna, Bryndis Birnir, Birnir, Bryndis,, Christophe Mallet (241657), Andersson, David A; id_orcid, Ana Gomis, Zygmunt, Peter, M, Hogestatt, Edward D., Högestätt, Edward, Movahed Rad, Pouya, Zygmunt Peter M., Mallet Christophe, Högestätt Edward D., Bevan Stuart, Högestätt, Edward,, Jönsson Bo A. G., Zygmunt, Peter,, Blomgren Anders, Lund University., Ermund, Anna,, Simonsen Charlotte, Movahed Rad, Pouya,, Jönsson, Bo A,, Ermund Anna, Andersson David A., Gomis Ana, Birnir Bryndis, Simonsen, Charlotte,, Blomgren, Anders,, Movahed Pouya, Eschalier Alain   +75 more
core   +2 more sources

Herbal Therapeutics in Osteoporosis: Mechanisms, Evidence, and Translational Potential

Phytotherapy Research, EarlyView.
Schematic overview of bone remodeling dysregulation in osteoporosis and the multi‐target protective role of herbal therapeutics. ABSTRACT Osteoporosis is a chronic bone disease marked by reduced density and increased fracture risk. Current treatments face limitations in safety, efficacy, and long‐term adherence, prompting interest in alternative ...
Elnaz Vafadar Moradi, Sina Vossoughinia, Zahra Yazdanpanah, Hossein Sobhani, Jalileh Jalali, Mahboobeh Ghasemzadeh Rahbardar   +5 more
wiley   +1 more source

Unique Responses are Observed in Transient Receptor Potential Ankyrin 1 and Vanilloid 1 (TRPA1 and TRPV1) Co-Expressing Cells

Cells, 2014
Transient receptor potential (TRP) ankyrin 1 (TRPA1) and vanilloid 1 (TRPV1) receptors are implicated in modulation of cough and nociception. In vivo, TRPA1 and TRPV1 are often co-expressed in neurons and TRPA1V1 hetero-tetramer formation is noted in ...
Laura R. Sadofsky, Koti T. Sreekrishna, Yakang Lin, Renee Schinaman, Kate Gorka, Yogita Mantri, John Christian Haught, Thomas G. Huggins, Robert J. Isfort, Charles C. Bascom, Alyn H. Morice   +10 more
doaj   +1 more source