Results 91 to 100 of about 27,030 (231)
The FEBS Journal, EarlyView.Basic excitability alterations that drive irregular spontaneous activity in primary nociceptors during chemotherapy‐induced peripheral neuropathy. Using an in vitro model of repeated paclitaxel application to dorsal root ganglion neurons that produces progressive axonal degeneration, Lamberti and colleagues show that all three basic excitability ...
Edgar T. Walters
wiley +1 more source
The Role of Neuropeptide Y in Dental Pulp: Balancing Neurogenic Inflammation and Pain Modulation
International Endodontic Journal, EarlyView.ABSTRACT Background Dental pulp is a densely innervated, low‐compliance tissue in which neurogenic inflammation can rapidly escalate into oedema, raised intrapulpal pressure, microvascular compromise, and pain. While Substance P (SP) and Calcitonin gene‐related peptide (CGRP) are well‐established drivers of pulp vasodilation, the Neuroopeptide Y (NPY ...
Javier Caviedes‐Bucheli +3 more
wiley +1 more source
Frontiers in Molecular NeuroscienceThe transient receptor potential vanilloid 1 (TRPV1) channel plays a dual role in peripheral neuropathic pain (NeuP) by acting as a “pain switch” through its sensitization and desensitization.
Ning Gao +4 more
doaj +1 more source
Swiss Practice Recommendations for Chronic Prurigo Including Prurigo Nodularis
International Journal of Dermatology, EarlyView.Chronic prurigo, including prurigo nodularis, is a chronic, often treatment‐refractory condition characterized by persistent pruritus and chronic scratch lesions. Advances in the understanding of its underlying pathophysiology have enabled the development of novel targeted therapies; however, management remains challenging due to the expanding range of
Simon M. Mueller +11 more
wiley +1 more source
Is Capsaicin Effective in Relieving the Symptoms of Burning Mouth Syndrome? A Systematic Review
Journal of Oral Rehabilitation, EarlyView.The capsaicin, administered topically or systemically, reduces pain symptoms in patients with Burning Mouth Syndrome (BMS). However, despite consistent clinical improvement, the current evidence is limited and of low certainty, highlighting the need for well‐designed studies to confirm its effectiveness. ABSTRACT Background Burning Mouth Syndrome (BMS)
Ana Paula de Andrade Silva +7 more
wiley +1 more source
Innovations in Obesity Treatment: Beyond Adipose Tissue Dysfunction
Obesity Reviews, EarlyView.Obesity drives chronic inflammation, insulin resistance, type 2 diabetes, and cancer development through adipocyte dysfunction. Addressing this multisystemic disorder requires integrated strategies beyond diet and exercise, such as thermogenesis activation via menthol or capsinoids and appetite control through GLP‐1/GIP agonists and neuromodulation to ...
Jesica Martínez‐Godfrey +7 more
wiley +1 more source
Oral Diseases, EarlyView.ABSTRACT Objective Pistacia lentiscus L. tree is known for its aromatic mastic gum containing terpenes α‐pinene and β‐myrcene, and has been applied as a traditional remedy in oral care for centuries. Previously, intranasal exposure to mastic resin volatiles increased salivary flow in healthy and dry‐mouth individuals. This study assessed the biological
Wiktoria Potocka +4 more
wiley +1 more source
Investigation of the Pathomechanism of Chronic Cough Using an In Vitro Approach
Clinical &Experimental Allergy, Volume 55, Issue 3, Page 247-249, March 2025.
Umesh Singh, Jonathan A. Bernstein
wiley +1 more source
The High‐Intensity Zone: A Dynamic Inflammatory Hub in Lumbar Disc Degeneration
Orthopaedic Surgery, EarlyView.The HIZ, a dynamic inflammatory hub in lumbar disc degeneration, links inflammation‐degeneration‐pain; integrating advanced diagnostics and targeted therapies offers precise management for discogenic low back pain. ABSTRACT The lumbar intervertebral disc high‐intensity zone (HIZ), a focal hyperintensity within the annulus fibrosus on T2‐weighted ...
Qi Zhou +6 more
wiley +1 more source