Results 101 to 110 of about 37,042 (291)
Pharmacoloical exploitations of trpv1 receptors
, 2017 The capsaicin receptor, transient receptor potential vanilloid type 1 ion channel (TRPV1), has been identified as a polymodal transducer molecule on a sub-set of primary sensory neurons which responds to various stimuli including noxious heat (>~42 °C),
Kjorsvik, Nina Elisabeth
core
TRPV1+ and TRPV1− similarly converge on NTS neurons.
, 2013 Overall, TRPV1− inputs (blue) to NTS neurons had shorter latencies than TRPV1+ inputs (red). A) Histogram of latency to EPSC onset. TRPV1− afferent inputs (n = 24 inputs) arrived more quickly than TRPV1+ (n = 32 inputs).
Michael C. Andresen (343872) +3 more
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Repurposing antimicrobial agents for neuroprotection: Mechanisms, clinical potential, and challenges
Neuroprotection, EarlyView.Antimicrobial agents exert neuroprotective effects through modulation of interconnected pathways. Tetracyclines, macrolides, antimalarial agents, sulfones, and antiparasitic agents suppress neuroinflammation, oxidative stress, and apoptosis while preserving mitochondrial function and neurotransmission.
Mohammad Amin Manavi +5 more
wiley +1 more source
Phytotherapy Research, EarlyView.Schematic overview of the multi‐target and multi‐pathway mechanisms of PDBI in the prevention and management of hypertension. ABSTRACT Hypertension remains a major global risk factor for cardiovascular diseases, yet current treatments face challenges such as suboptimal blood pressure control and inadequate organ protection.
Qiqi Deng +6 more
wiley +1 more source
Frontiers in Bioscience-LandmarkDry eye disease (DED) is a prevalent ophthalmic ailment with intricate pathogenesis and that occurs primarily due to various factors which affect the ocular surface.
Qingqing Gou +3 more
doaj +1 more source
(A, B, E, F) Immunohistochemistry of MHCII (grayscale) and neuronal marker PGP9.5 (red) in L4 DRG tissue from TRPV1-lineage MHCII+/+ (WT), MHCII+/- (cHET) and MHCII-/- (cKO) naïve and day 14 PTX-treated female and male mice. Number = neuron diameter size,
Riley C. Cott (17935738) +3 more
core +1 more source
, 2013 Upper panels: A. TRPV1 siRNA – sequence No. 1: Knockdown of TRPV1, using siRNA, in HEK-293 and HT-29 cells resulted in inhibition of Hsp90, and Hsp70 expression. HEK293 & HT-29 cells were treated with either oligofectamine alone, heat shock at 42°C for 3
Younousse Saidi (382999) +3 more
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Phytotherapy Research, EarlyView.Graphical representation of ethnomedical uses, major bioactive compounds, pharmacological potential and toxicological risks of Ruta graveolens L. ABSTRACT Ruta graveolens L. is widely used in traditional European, Asian, African, and South American medicine for digestive, nervous, cardiovascular, respiratory, and reproductive disorders.
Tetiana Serhiienko +3 more
wiley +1 more source
Efeito antinociceptivo do eugenol em um modelo de dor muscular orofacial em camundongos: participação dos receptores glutamatérgicos, TRPs e ASICs [PDF]
, 2013 Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Neurociências, Florianópolis, 2012As Disfunções Temporomandibulares (DTMs) compreendem um grupo de distúrbios que podem acometer os ...
Dal Bó, Wladmir Antônio de Souza
core
Comparison of TRPV1 and TRPV1/mSlo1 currents.
, 2013 A, The time coruse of the TRPV1 currents. The TRPV1 currents, expressed in HEK293 cells, were recorded with repetitive voltage steps from -60 to 0 mV with a time interval of 2 seconds, before, during, and after the application of 5 μM Capsaicin as ...
Ying Wu (19057) +10 more
core +1 more source