Results 101 to 110 of about 13,621 (198)
TRPV1 expression in human cultured PTEC.
, 2013 A. Human PTECs were marked with DAPI and stained with a primary anti-TRPV1 antibody (giunea-pig polyclonal serum); omission of a primary antibody served as negative control (B). C.
Bastian Theisinger (310806) +14 more
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Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?
British Journal of Pharmacology, EarlyView.Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli +7 more
wiley +1 more source
TRPV1 Inhibits Ferroptosis and Mitophagy to Alleviate Heart Failure by Activating SFXN2
Frontiers in Bioscience-LandmarkBackground: Heart failure (HF) continues to represent a significant global public health concern. Transient receptor potential cation channel subfamily V member 1 (TRPV1) is a calcium-permeable channel that has been linked to cardiac ...
Pan Liu +8 more
doaj +1 more source
, 2006 Title page and Table of contents Introduction Results Discussion Summary Future Prospect Materials Methods References CV Publications Acknowledgements AbbreviationsThe transmission of pain signalling involves the cytoskeleton ...
Goswami, Chandan
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Novel approaches for drug development against chronic primary pain: A systematic review
British Journal of Pharmacology, EarlyView.Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus +5 more
wiley +1 more source
TRPV1 levels in of sperm cells selected by pharmacological modulation of TRPV1.
, 2016 A) TRPV1 protein expression of sperm cells migrated towards a 10 μM CPS gradient (CPS) or towards a 10 μM CPS gradient with pre-incubation with 10 μM CPZ (CPS+CPZ) or towards a 31–37°C temperature gradient with pre-incubation with 10 μM CPZ (T gradient +
Carlo Foresta (36982) +9 more
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British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Chemotherapy‐induced peripheral neuropathy (CIPN) is a prevalent and treatment‐resistant side effect of platinum‐based chemotherapy, characterised by mechanical allodynia. Cannabigerol (CBG), a non‐psychoactive cannabinoid, has shown antinociceptive potential, but its site and mechanism of action remain unclear.
Quinn W. Wade +7 more
wiley +1 more source
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016 Background The transient receptor potential vanilloid 1 (TRPV1) mediates cellular responses to pain, heat, or noxious stimuli by calcium influx; however, the cellular localization and function of TRPV1 in the cardiomyocyte is largely unknown.
Carl M. Hurt +9 more
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Activation and Regulation of TRPV1 : Studies in Recombinant Human Neuroblastoma TRPV1-SHSY5Y Cells
, 2009 TRPV1 is a transmembrane non-selective cation channel with preference for Ca2+. The receptor is primarily localised on dorsal root ganglion neurons and is activated by numerous endogenous and exogenous potentially irritating ligands eliciting pain.
Forsby, Anna, +2 more
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Immunolocalization of TRPV1 at symmetric synapses in mouse dentate ML.
, 2015 Preembedding immunogold method for electron microscopy (A-C). In TRPV1-WT (A, B), silver-intensified gold particles (arrowheads) are mostly distributed in dendritic (den) profiles but not in inhibitory synaptic terminals (ter).
Juan Mendizabal-Zubiaga (342146) +7 more
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