Results 121 to 130 of about 27,030 (231)

Molecular Mechanisms of Food Bioactive Constituents in the Management of Obesity and Hypertension: A Critical Review

Phytochemicals in Food and Medicine, Volume 1, Issue 3, September 2026.
Obesity and hypertension co‐exist and share molecular mechanisms in terms of dietary therapy, modulated by food bioactive constituents. ABSTRACT Obesity and hypertension are among the most pressing global public health challenges. They frequently co‐exist, with obesity‐related hypertension accounting for an estimated 75% of the hypertension burden ...
Samuel Oluwasegun Maccarthy, Emmanuel Anyachukwu Irondi, Abdulazeez Olamilekan Elemosho, Emmanuel Oladipo Ajani   +3 more
wiley   +1 more source

TRPV1 in skeletal muscles mediates the improvement of cardiac function induced by acupuncture at the PC6 acupoint in rats with acute myocardial infarction. [PDF]

Chin Med
Liu X, Wu Y, Zhai Y, Gao W, Meng X, Pei W, Fang Y, Guo Y, Liu Y.   +8 more
europepmc   +1 more source

Peripheral κ opioid receptor in pain and inflammation: From molecular signalling and gene expression to drug discovery

British Journal of Pharmacology, Volume 183, Issue 17, Page 5157-5189, September 2026.
The κ opioid receptor (κ receptor, KOR) is a G protein‐coupled receptor with well established roles in analgesia and immune modulation. Although historically studied primarily in the central nervous system (CNS), growing evidence indicates that κ signalling in peripheral tissues plays an important role in regulating pain, inflammation and immune ...
Rumsha Khan, Elena C. A. Becker, Boglarka B. Bata, Christian W. Gruber   +3 more
wiley   +1 more source

Modulating Protein Function through Genetically Encoded Oxidative Chemistry. [PDF]

J Am Chem Soc
Li H, Pavlič A, Ibrahim NE, Wu D, Shapiro MG.   +4 more
europepmc   +1 more source

Canoe full of hot paddlers: TRPV1 neurons steering cardiorespiratory control

The Journal of Physiology, EarlyView.
Richard J. A. Wilson, Nicholas Jendzjowsky   +1 more
wiley   +1 more source

Natural Agents for Preventing Skin Damage Induced by Visible Light: A Systematic Review of Preclinical and Clinical Evidence

Photodermatology, Photoimmunology &Photomedicine, Volume 42, Issue 5, September 2026.
ABSTRACT Background/Purpose Visible light (VL), and particularly high‐energy visible light (HEVL), reaching Earth's surface has emerged as a relevant contributor to skin damage. VL has been implicated in oxidative stress, inflammation, pigmentation disorders, and photoaging, especially in individuals with darker skin phototypes.
Azahara Rodríguez‐Luna, Alicia Zamarrón, Cristina García‐Muñoz, Juan‐Carlos Hernández‐Rodríguez, Henry W. Lim, Salvador González   +5 more
wiley   +1 more source

TRPA1 and TRPV1 Receptors Protect the Gastric Mucosa from Ethanol-Induced Injury: Evidence from Knockout Mice. [PDF]

Cells
Zalecki M, Kun J, Juranek J, Antushevich H, Helyes Z, Pintér E.   +5 more
europepmc   +1 more source

CPTCs Drive Somatic‐Visceral Communication via the Wnt Axis in Somatic Mechanotherapy: A Single‐Cell Deep Learning Study

The FASEB Journal, Volume 40, Issue 15, 15 August 2026.
Using an interpretable deep learning framework (CARSS) applied to multi‐tissue single‐cell RNA sequencing, we identify CD34⁺PDGFRα⁺ telocytes (CPTCs) as the primary mechanosensors bridging somatic acupuncture stimulation and visceral repair. Mechanical force at acupoints activates an AP‐1/Hsp70 immediate‐early gene program in fascial CPTCs, triggering ...
Haixiang Huang, Zhenwei Zhang, Bingbing Shen, Jianming Yue, Lu Mei, Xudong Zhu, Yonghong Shi, Qianmei Zhu, Yeping Shi, Yifan Luo, Yitong Xing, Meng Dai, Qiusheng Chen   +12 more
wiley   +1 more source

Immunometabolic and immune regulatory functions of capsaicin in cancer: mechanistic insights and emerging perspectives. [PDF]

Front Immunol
Xie K, Qi Z, Chen Z, Zhang R, Liu L, Li W, Cao D, Xie D, Shen J.   +8 more
europepmc   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, Volume 16, Issue 8, Page 1477-1490, August 2026.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source