Results 141 to 150 of about 37,042 (291)

Dependence of TRPV1 components upon cellular expression level in living cells expressing TRPV1-YFP.

, 2015
The graphs show the inverse of relative amplitudes of the three components of TRPV1 vs. average fluorescence intensity; the latter quantity is proportional to protein expression level in living cells.
Francesco Cardarelli (249459), Ranieri Bizzarri (589494), Carmine Di Rienzo (701316), Barbara Storti (193389), Fabio Beltram (193397)   +4 more
core   +1 more source

The ongoing oleoylethanolamide story: Therapeutic implications in the control of obesity and its comorbidities

British Journal of Pharmacology, EarlyView.
The global burden of obesity continues to rise, demanding effective pharmacological strategies for individuals in whom prevention alone is insufficient. Recent incretin‐based and multi‐agonist therapies have delivered unprecedented weight loss, demonstrating that the simultaneous modulation of multiple metabolic pathways can optimize body weight ...
Marzia Friuli, Alessia Campagna, Barbara Eramo, Christian Sepe, Annarita Zuena, Silvana Gaetani, Adele Romano   +6 more
wiley   +1 more source

Chemical Characterization and Pharmacological Activity of Byrsonima crassifolia (L.) Kunth (Murici): Antinociceptive Effects, Edema Reduction, and Molecular Docking. [PDF]

Chem Biodivers
Hydroethanolic extracts from Byrsonima crassifolia leaves and bark exhibit potent anti‐inflammatory and antinociceptive activities in zebrafish. Phenolic compounds, particularly kaempferol‐3‐O‐rutinoside, isoquercitrin, and rutin, target TRPA1, TRPV1, and COX‐2, integrating phytochemical, biological, and molecular docking evidence to support murici as ...
Frota LS, Barbosa SICG, de Oiveira MRC, do Nascimento GA, Santos SAAR, Ishiki HM, Magalhães FEA, Campos AR, de Morais SM.   +8 more
europepmc   +2 more sources

Effect of the venom of Conus princeps and Anthopleura sp. on the TRPV1 channel

, 2012
El receptor de potencial transitorio vaniloide 1 o TRPV1 por su siglas en inglés (Transient Receptor Potencial Vanilloid 1) es un canal catiónico tetramérico no selectivo con alta permeabilidad a Ca+2.
Jennifer Medina Elizalde
core  

TRPM3 regulates fear memory encoding and seizure susceptibility in the lateral amygdala

British Journal of Pharmacology, EarlyView.
Abstract Background and purpose TRPM3 is best known for its role as a peripheral sensor of pain and heat. Recent studies reporting gain‐of‐function TRPM3 mutations in patients with neurodevelopmental and epilepsy‐associated disorders suggest a previously unrecognized role of this channel in the brain.
Attila Gyéresi, Laura Mundrucz, Máté Deák, Angéla Kecskés, Éva Borbély, Viktória Kormos, Balázs Gaszner, Orsolya Mihály, Balázs István Tóth, Joris Vriens, Thomas Voets, Erzsébet Kövesdi, Miklós Kecskés   +12 more
wiley   +1 more source

TRPV1 immunoreactivity in vascular smooth muscle cells.

, 2013
Rat dorsal root ganglia sections were co-stained by anti TRPV1 (red) and anti vascular smooth muscle actin (SMA, green) antibodies. Some of the TRPV1 positive cells were co-stained by the antibody specific to vascular smooth muscle actin, suggesting ...
Zoltán Papp (5656855), Róbert Pórszász (481520), Ágnes Czikora (481516), Andrea Szalai (481519), Enikő T. Pásztor (481518), Attila Tóth (2847734), Judit Boczán (481521), István Édes (481522), Ibolya Rutkai (481517)   +8 more
core   +1 more source

Effects of 6‐OHDA‐Mediated Chemical Denervation of Sympathetic Axons in Inguinal Subcutaneous White Adipose Tissue

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims White adipose tissue (WAT) innervation by sensory and sympathetic axons contributes to tissue functions, but the consequences of selectively disrupting sympathetic input to WAT remain incompletely defined. Materials and Methods We utilised 6‐hydroxydopamine (6‐OHDA) as a validated approach to achieve bilateral sympathetic denervation of ...
Gilian Gunsch, Gargi Mishra, Magdalena Blaszkiewicz, Erica de Sousa, Jake W. Willows, Katharine W. Alltop, Annemarie Towle, Shawn Collins, Andre Khalil, Isabel F. Snodgrass, Lara Agha, Kiran Prakash, Rashmika Maganuru, Sugasini Dhavamani, John W. Newman, Kristy L. Townsend   +15 more
wiley   +1 more source

Inhibition of pyroptosis and apoptosis by capsaicin protects against LPS-induced acute kidney injury through TRPV1/UCP2 axis in vitro

Open Life Sciences, 2023
Han Jinrun, Wu Jinhao, Liu Hong, Huang Yu, Ju Wen, Xing Yifei, Zhang Xiaoping, Yang Jun   +7 more
doaj   +1 more source

Silver nanoparticles stimulate 5-Fluorouracil-induced colorectal cancer cells to kill through the upregulation TRPV1-mediated calcium signaling pathways

openIn questo articolo è presentata la capacità di TRPV1 di fungere da oncosoppressore grazie alla stimolazione con nanoparticelle d’argento e 5- fluorouracile.
ANTOLINI, GAIA
core  

Persistent in vitro nociceptor hyperexcitability and axonal retraction produced by repeated paclitaxel doses

The FEBS Journal, EarlyView.
Repeated paclitaxel exposure causes long‐lasting nociceptor hyperexcitability and axonal retraction in adult sensory neurons. Using a long‐term primary nociceptor culture, we show that hyperexcitability is mediated by sequential upregulation of NaV1.8, TRPV1, TRPA1, and TRPM8 channels.
Angela Lamberti, Victor Moreno Lozano, Asia Fernández‐Carvajal, Antonio Ferrer‐Montiel   +3 more
wiley   +1 more source