Results 141 to 150 of about 27,030 (231)

The Relationship Between (Endo)cannabinoids, the Microbiome and Melanoma

Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
CB1 and CB2 receptors are widely distributed in both normal and cancerous cells. Cannabinoids have a positive impact on reducing tumor growth in mice. A positive relationship exists between CB2 receptors and survival in skin melanoma. However, there is a negative impact on non‐small cell lung cancer and colon cancer, whereas a higher association of CB1
Farideh A. Javid, Marin Golčić, Anja Harej Hrkać, Andrej Belančić   +3 more
wiley   +1 more source

Bidirectional Roles of TRPV1 in a Latent Sensitization Model of Myofascial Low Back Pain. [PDF]

Eur J Pain
Blechschmidt V, Schlickenrieder B, Husk JR, Hoheisel U, Mörz H, Treede RD, Greffrath W.   +6 more
europepmc   +1 more source

Microenvironment‐Responsive Drug Delivery Systems for Ocular Surface Diseases: Mechanisms, Applications, and Translational Challenges

Small Science, Volume 6, Issue 8, August 2026.
Microenvironment‐responsive drug delivery systems overcome ocular physiological barriers by responding to temperature, pH, ions, reactive oxygen species, and enzymes. This review bridges material design, performance evaluation, and clinical translation, offering actionable insights for treating dry eye disease, infectious keratitis, and corneal ...
Jiamin Liu, Liangbo Chen, Yao Fu, Siyi Zhang   +3 more
wiley   +1 more source

TRPV1-linked neuropeptide axes in periodontitis and peri-implantitis. [PDF]

Front Endocrinol (Lausanne)
Lin Y, He Q, Ni J, Ye S, Chen L, Wu Y, Zhang C.   +6 more
europepmc   +1 more source

Complex Contributions of Methylglyoxal to Pain, Axon Degeneration, and Diabetic Peripheral Neuropathy

Journal of Neurochemistry, Volume 170, Issue 8, August 2026.
This work reviews how the metabolic by‐product methylglyoxal may contribute to the development of diabetic peripheral neuropathy (DPN), a common complication of diabetes characterized by nerve damage and chronic pain in the extremities. In diabetes, methylglyoxal levels rise due to increased glucose metabolism and reduced detoxification capacity. While
Gentry Totta‐Griese, Douglas E. Wright
wiley   +1 more source

Bioinformatics analysis of TRPV1 expression and its role in hepatocellular carcinoma prognosis. [PDF]

Discov Oncol
Kashyap VK, Sharma BP, Singh HN, Kumar S, Verma D, Parashar D, Yallapu MM, Cobos E, Chauhan SC.   +8 more
europepmc   +1 more source

Effectiveness and Tolerability of Topical Amitriptyline 10% Plus Lidocaine 2% Gel in Adults With Post‐Traumatic Trigeminal Neuropathic Pain: A Real‐World Evidence Study

Journal of Oral Rehabilitation, Volume 53, Issue 8, Page 1550-1561, August 2026.
A compounded amitriptyline 10% plus lidocaine 2% mucoadhesive gel was associated with substantial pain improvement and favourable tolerability in adults with post‐traumatic trigeminal neuropathic pain (PTNP). These findings support targeted mucosal delivery as a promising practical local option and a potential medication‐sparing strategy, particularly ...
Ashley Lebel, Imen Stambouli, Yves Boucher   +2 more
wiley   +1 more source

Inhibition of Microglial TRPV1 Ameliorates Brain Injury After Intracerebral Hemorrhage by Suppressing AMPK/PINK1-Mediated Mitophagy. [PDF]

CNS Neurosci Ther
Chen K, Deng X, Zeng J, Sun B, Yu J, Li T, Zhong J, Hong P, Wang P, Li F, Zhang Q, Ren J, Tang Q, Zhu T, Zhu J.   +14 more
europepmc   +1 more source

Effects of Combined Transcranial Direct Current Stimulation and Oral Capsaicinoids on Swallowing Function: A Randomized Controlled Trial

Journal of Oral Rehabilitation, Volume 53, Issue 8, Page 1543-1549, August 2026.
We investigated the effects of combined transcranial direct current stimulation (tDCS) and oral capsaicinoids on swallowing function in 21 healthy young adults. The combined cortical and peripheral sensory intervention could potentially facilitate swallowing.
Ivy Cheng, Sonja Suntrup‐Krüger
wiley   +1 more source

Validation of TRPA1 and TRPV1 Antibodies for Expression Detection in Mammalian Cells and Tissues. [PDF]

J Neurochem
de Las Casas M, Hernández-Ortego P, Torres-Montero R, De la Peña E, Gomis A, Viana F, Fernández-Trillo J.   +6 more
europepmc   +1 more source