Results 131 to 140 of about 27,030 (231)

Effect of Pulsed Radiofrequency with Various Time-Course on Rheumatoid Arthritis Joint Pain in Rats. [PDF]

J Pain Res
Li X, Wang M, Wang Y, Zhao G, Gao J, Wang C.   +5 more
europepmc   +1 more source

HOF‐Stabilized Apple EV Nanocargo in an NIR‐Responsive Hydrogel Enables On‐Demand Therapeutic Modulation for Transdermal Deep‐Joint Osteoarthritis Therapy

Advanced Healthcare Materials, Volume 15, Issue 29, 7 August 2026.
An NIR‐responsive transdermal hydrogel integrating apple EV nanocargo, berberine, piperine, HOFs, and graphene oxide enables localized osteoarthritis modulation. The platform supports enhanced transdermal delivery together with mild hyperthermia‐associated and redox‐related responses, leading to reduced inflammation and oxidative stress, improved ...
Yu‐Wen Tseng, Pei‐Wei Weng, Hsien‐Tsung Lu, Jiunn‐Horng Kang, Lekha Rethi, Lekshmi Rethi, Yan‐Ting Chen, Hieu Trung Nguyen, Yao‐Tung Tsai, Andrew E.‐Y. Chuang   +9 more
wiley   +1 more source

Investigation of Sevoflurane-Induced Apoptotic Damage in Human Cardiomyocytes and the Protective Efficacy of Ascorbic Acid. [PDF]

Medicina (Kaunas)
Aydoğan E, Övey İS, Karahan O.
europepmc   +1 more source

Heart‐Specific Spinal and Vagal Afferents: Transcriptomic Signatures and Optogenetically Modulated Functional Coupling With Cardiomyocytes

Comprehensive Physiology, Volume 16, Issue 4, August 2026.
Selective purification of heart‐specific spinal and vagal sensory neurons by retrograde labeling and FACS purification showed enhanced spontaneous, optogenetic, and chemically stimulated Ca2+ activity. Transcriptomic profiling identified distinct ion channel and GPCR signatures in heart‐specific sensory neurons.
T. Akgul Caglar, Y. E. Kazci, Z. B. Durdu, S. Sahoglu Goktas, S. Bay, E. Vatandaslar, M. U. Turhan, G. Ozturk, E. Cagavi   +8 more
wiley   +1 more source

Gatekeepers of Pain: A Scoping Review on How Nanoparticle Engineering Illuminates Selective Transient Receptor Potential Vanilloid 1 (TRPV1) Targeting. [PDF]

Cureus
Xiang AQ, Cho E, Jiang T, Balraj N, Abu-Baker S.   +4 more
europepmc   +1 more source

Early and Divergent Lipid Mediator Remodelling in Fast Versus Slow Skeletal Muscles of Female hSOD1G93A Mice

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 4, August 2026.
ABSTRACT Background Skeletal muscle atrophy in amyotrophic lateral sclerosis (ALS) drives loss of muscle strength, function and quality of life in ALS patients. The endocannabinoid system (ECS) regulates muscle homeostasis via regenerative and metabolic processes, and although ECS alterations have been reported in ALS neural tissues, ECS remodelling ...
Sebastiaan Dalle, Kaat Vanderbeke, Thibaut Burg, Moniek Schouten, Wout Lauriks, Nicole Hersmus, Ludo Van Den Bosch, Katrien Koppo   +7 more
wiley   +1 more source

Synthesis and Characterization of Zn‐Doped Fe3O4 Nanoparticles for Magnetic Hyperthermia: In Vitro Test Against Thermoresistant Pseudomonas aeruginosa and Candida albicans

Nano Select, Volume 7, Issue 8, August 2026.
Zn0.03Fe2.97O4 nanoparticles synthesized via a solvothermal route exhibit enhanced magnetic properties and efficient heating under safe clinical limits. This study reveals a synergistic antimicrobial mechanism against thermoresistant P. aeruginosa and C. albicans.
Flavio Cesar Franyutti‐Villegas, Ulises Salazar‐Kuri, Jorge Antonio Salinas‐Hernández, René Pablo Manzano‐Villanueva, Norma E. Rojas‐Ruiz, Nery Martha‐Aguilar, María Guadalupe López‐Merino, Miguel Ángel Méndez‐Rojas   +7 more
wiley   +1 more source

Endothelial TRPV1 Drives Choroidal Neovascularization in Wet Age-Related Macular Degeneration via NF-κB Signaling. [PDF]

Invest Ophthalmol Vis Sci
Sun N, Li J, Wang J, Wang J, Chen T, Wang Y, Liu C, Yang S, Yao T, Feng H, Wang Z.   +10 more
europepmc   +1 more source

Could NAPQI Contribute to Paracetamol Analgesia? Redox Modulation of Kv7 Ion Channels

Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
ABSTRACT Paracetamol (acetaminophen, APAP) is one of the most widely used analgesic and antipyretic drugs worldwide, yet its mechanism of action remains incompletely understood. While several pathways have been proposed, including cyclooxygenase inhibition and endocannabinoid modulation via AM404, none fully account for its pharmacological profile. The
Sara M‐Alicante, Janire Urrutia, Arantza Muguruza‐Montero, Miren Revuelta, Ane Arrizabalaga‐Iriondo, Alvaro Villarroel, Eider Nuñez   +6 more
wiley   +1 more source

<i>In Silico</i> Identification of Cholesterol Binding Sites in the Transient Potential Receptor Vanilloid 1 (TRPV1) Ion Channel. [PDF]

J Phys Chem B
Morris J, Eardley-Brunt ASJ, Blayney AM, Domene C.   +3 more
europepmc   +1 more source