Results 41 to 50 of about 64,951 (237)

Capsaicin treatment attenuates cholangiocarcinoma carcinogenesis.

PLoS ONE, 2014
UnlabelledCapsaicin, the most abundant pungent molecule produced by pepper plants, represents an important ingredient in spicy foods consumed throughout the world.
Annika Wutka, Vindhya Palagani, Samarpita Barat, Xi Chen, Mona El Khatib, Julian Götze, Hanane Belahmer, Steffen Zender, Przemyslaw Bozko, Nisar P Malek, Ruben R Plentz   +10 more
doaj   +1 more source

Capsaicin Potentiates Anticancer Drug Efficacy Through Autophagy-Mediated Ribophorin II Downregulation and Necroptosis in Oral Squamous Cell Carcinoma Cells

Frontiers in Pharmacology, 2021
The ability of capsaicin co-treatment to sensitize cancer cells to anticancer drugs has been widely documented, but the detailed underlying mechanisms remain unknown.
Yi-Ching Huang, Tien-Ming Yuan, Bang-Hung Liu, Kai-Li Liu, Kai-Li Liu, Chiung-Hua Wung, Show-Mei Chuang   +6 more
doaj   +1 more source

Capsaicin protects neuromuscular junctions from the inhibitory effects of botulinum neurotoxin A [PDF]

, 2008
Within 24 hrs after injecting botulinum neurotoxin A (BoNT/A) into the hindlimb, mice lost the toe spread reflex and developed progressive muscle weakness. At the same time, the compound muscle action potential amplitude decreased. Injection of capsaicin
Baskaran Thyagarajan, Carmen Garcia, Joseph McArdle, Joseph Potian, Kormakur Hognason, Natalia Krivitskaya   +5 more
core   +1 more source

Spicy science: David Julius and the discovery of temperature-sensitive TRP channels. [PDF]

, 2015
This invited biographical review covers the career of Dr. David Julius and his discovery of thermosensitive TRP channels. Dr. Julius is currently the Morris Herzstein Chair in Molecular Biology and Medicine and Professor and Chair of Physiology at the ...
Bautista, Diana
core   +2 more sources

Nigra‐Subthalamic Dopaminergic Circuitry Modulates and Represents Distinct Pain Modality in Physiological and Pain States in Mice

Advanced Science, EarlyView.
Nigral dopaminergic (DA) neurons modulate and represent pain with a preference to a particular modality (mechanical) and laterality (contralateral), which are controlled by nigral GABAergic neurons. The pain modulation is mimicked by the nigro‐subthalamic projection and its downstream neurons, involving D2‐like receptors.
Ying Ji, Shuyi Li, Jiaqi Zhang, Xiang‐Ying Xu, Cui Yin, Mu Niu, Danyang Liu, Yanyu Jiang, Yong Niu, Su Liu, Bin Zhang, Guiyun Cui, Chunyi Zhou, Cheng Xiao   +13 more
wiley   +1 more source

Experimental Evidence for Alleviating Nociceptive Hypersensitivity by Single Application of Capsaicin

Molecular Pain, 2015
The single application of high-concentration of capsaicin has been used as an analgesic therapy of persistent pain. However, its effectiveness and underlying mechanisms remain to be further evaluated with experimental approaches.
Xiao-Li Ma, Fang-Xiong Zhang, Fei Dong, Lan Bao, Xu Zhang   +4 more
doaj   +1 more source

MODEL KINETIKA DEGRADASI CAPSAICIN CABAI MERAH GILING PADA BERBAGAI KONDISI SUHU PENYIMPANAN (Kinetic Model of Capsaicin Degradation on Red Chilli Paste at Various Storage Temperature)

Agritech, 2014
The objective of this research was to asses relationship between temperature and storage time of capsaicin degradation of red chilli paste and to measure activation energy and shelf life using the Arrhenius model.
Dharia Renate, Filli Pratama, Kiki Yuliati, Gatot Priyanto   +3 more
doaj   +1 more source

Capsaicin Attenuates Lipopolysaccharide-Induced Inflammation and Barrier Dysfunction in Intestinal Porcine Epithelial Cell Line-J2

Frontiers in Physiology, 2021
Capsaicin is a spicy, highly pungent, colorless, vanilloid compound found in chili peppers with anti-inflammatory, antioxidant, anti-cancer, and analgesic properties.
Xiaoya Zhao, Bingqi Dong, Marissa Friesen, Shangxi Liu, Changqing Zhu, Chengbo Yang   +5 more
doaj   +1 more source

Functional Disorder at the Neural Interface: How Disordered Nanostructures Promote Proper Growth and Differentiation in In Vitro Neural Cultures

Advanced Science, EarlyView.
This work provides a practical guide for neuroengineers to design advanced neural interfaces, embracing and tailoring the concept of functional disorder. By bridging 2D and 3D in vitro models, this work highlights how non‐periodic, spatially heterogeneous, multiscale nanotopography can enable more physiologically relevant platforms for studying neural ...
F. Maita, E. Palmieri, I. Lucarini, L. Montaina, L. Maiolo   +4 more
wiley   +1 more source

Capsaicin-Induced Ca2+ Influx and Constriction of the Middle Meningeal Artery [PDF]

, 2014
Research in the past on transient receptor potential cation channel subfamily V member 1 (TRPV1) has been limited to mainly nervous tissue TRPV1 because of the channel’s role in pain perception.
Koide, Masayo, Kotlikoff, Michael I., Manuelyan, Inessa, Shui, Bo, Syed, Arsalan U., Wellman, George C.   +5 more
core   +1 more source