Proton block of proton-activated TRPV1 current. [PDF]
, 2015 The TRPV1 cation channel is a polymodal nociceptor that is activated by heat and ligands such as capsaicin and is highly sensitive to changes in extracellular pH. In the body core, where temperature is usually stable and capsaicin is normally absent, H(+)
Lee, Bo Hyun, Zheng, Jie
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Cancer Medicine, 2022 Background & Aims Capsaicin, a functional component of chili pepper, possesses anti‐inflammatory, analgesic, and anti‐cancer properties. This study aimed to determine the property of capsaicin against hepatocarcinogenesis in vivo and investigate the role
Zhi‐Qin Xie +6 more
doaj +1 more source
Selective disruption of high sensitivity heat activation but not capsaicin activation of TRPV1 channels by pore turret mutations. [PDF]
, 2012 The capsaicin receptor transient receptor potential vanilloid (TRPV)1 is a highly heat-sensitive ion channel. Although chemical activation and heat activation of TRPV1 elicit similar pungent, painful sensation, the molecular mechanism underlying ...
Cao, Xu +5 more
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Differences in the Control of Secondary Peristalsis in the Human Esophagus: Influence of the 5-HT4 Receptor versus the TRPV1 Receptor. [PDF]
PLoS ONE, 2016 Acute administration of 5-hydroxytryptamine4 (5-HT4) receptor agonist, mosapride or esophageal infusion of the transient receptor potential vanilloid receptor-1 (TRPV1) agonist capsaicin promotes secondary peristalsis.
Chih-Hsun Yi +6 more
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Pressurised Liquid Extraction of Capsaicinoids from Peppers [PDF]
, 2006 Se presenta el desarrollo de un método de extracción de capsaicinoides en pimientos mediante la técnica de extracción mediante fluidos ...
Fernández Barbero, Gerardo +2 more
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Nature Communications, 2018 The capsaicin receptor TRPV1 has been structurally characterized, but the capsaicin activation dynamics remain elusive. Here authors use fluorescent unnatural amino acid incorporation, computational modeling and Φ-analysis to derive the capsaicin-bound ...
Fan Yang +6 more
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NGX-4010, a capsaicin 8% patch, for the treatment of painful HIV-associated distal sensory polyneuropathy: integrated analysis of two phase III, randomized, controlled trials [PDF]
, 2013 BACKGROUND HIV-associated distal sensory polyneuropathy (HIV-DSP) is the most frequently reported neurologic complication associated with HIV infection.
Brew, Bruce J +9 more
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N-Arachidonoyl Dopamine Modulates Acute Systemic Inflammation via Nonhematopoietic TRPV1. [PDF]
, 2017 N-Arachidonoyl dopamine (NADA) is an endogenous lipid that potently activates the transient receptor potential vanilloid 1 (TRPV1), which mediates pain and thermosensation. NADA is also an agonist of cannabinoid receptors 1 and 2.
Hellman, Judith +7 more
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Capsaicin triggers autophagic cell survival which drives epithelial mesenchymal transition and chemoresistance in bladder cancer cells in an Hedgehog-dependent manner [PDF]
, 2016 Bladder cancer (BC) is a common urologic tumor characterized by high risk of recurrence and mortality. Capsaicin (CPS), used as an intravesical drug for overactive bladder, was demonstrated to induce cell death in different cancer cells including BC ...
Amantini, C +6 more
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The effects of Hot Pepper Extract and Capsaicin on Adipocyte Metabolism
Journal of Pharmacopuncture, 2008 Objectives : The purpose of this study is to investigate the effects of hot pepper extract and capsaicin on the adipogenesis in 3T3-L1 cells, lipolysis in rat epididymal adipocytes and histological changes in porcine adipose tissue.
Ching Sheng, Chu +3 more
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