Results 31 to 40 of about 40,616 (253)

Differences in the Control of Secondary Peristalsis in the Human Esophagus: Influence of the 5-HT4 Receptor versus the TRPV1 Receptor. [PDF]

PLoS ONE, 2016
Acute administration of 5-hydroxytryptamine4 (5-HT4) receptor agonist, mosapride or esophageal infusion of the transient receptor potential vanilloid receptor-1 (TRPV1) agonist capsaicin promotes secondary peristalsis.
Chih-Hsun Yi, Wei-Yi Lei, Jui-Sheng Hung, Tso-Tsai Liu, William C Orr, Pace Fabio, Chien-Lin Chen   +6 more
doaj   +1 more source

The conformational wave in capsaicin activation of transient receptor potential vanilloid 1 ion channel

Nature Communications, 2018
The capsaicin receptor TRPV1 has been structurally characterized, but the capsaicin activation dynamics remain elusive. Here authors use fluorescent unnatural amino acid incorporation, computational modeling and Φ-analysis to derive the capsaicin-bound ...
Fan Yang, Xian Xiao, Bo Hyun Lee, Simon Vu, Wei Yang, Vladimir Yarov-Yarovoy, Jie Zheng   +6 more
doaj   +1 more source

Capsaicin suppresses hepatocarcinogenesis by inhibiting the stemness of hepatic progenitor cells via SIRT1/SOX2 signaling pathway

Cancer Medicine, 2022
Background & Aims Capsaicin, a functional component of chili pepper, possesses anti‐inflammatory, analgesic, and anti‐cancer properties. This study aimed to determine the property of capsaicin against hepatocarcinogenesis in vivo and investigate the role
Zhi‐Qin Xie, Hong‐Xia Li, Xiao‐Juan Hou, Mei‐Yuan Huang, Ze‐Min Zhu, Li‐Xin Wei, Cai‐Xi Tang   +6 more
doaj   +1 more source

Capsaicin-Coated Silver Nanoparticles Inhibit Amyloid Fibril Formation of Serum Albumin

, 2016
We have synthesized capsaicin-coated silver nanoparticles (AgNPsCap) and have tested their anti-amyloid activity, considering serum albumin (BSA) as a model protein.
Dolat Singh Shekhawat (2820049), Bibin G. Anand (1697590), Karunakar Kar (1341003), Kriti Dubey (1697596)   +3 more
core   +1 more source

The effects of Hot Pepper Extract and Capsaicin on Adipocyte Metabolism

Journal of Pharmacopuncture, 2008
Objectives : The purpose of this study is to investigate the effects of hot pepper extract and capsaicin on the adipogenesis in 3T3-L1 cells, lipolysis in rat epididymal adipocytes and histological changes in porcine adipose tissue.
Ching Sheng, Chu, Ki Rok, Kwon, Tae Jin, Rhim, Dong Heui, Kim   +3 more
doaj   +1 more source

MODEL KINETIKA DEGRADASI CAPSAICIN CABAI MERAH GILING PADA BERBAGAI KONDISI SUHU PENYIMPANAN (Kinetic Model of Capsaicin Degradation on Red Chilli Paste at Various Storage Temperature)

Agritech, 2014
The objective of this research was to asses relationship between temperature and storage time of capsaicin degradation of red chilli paste and to measure activation energy and shelf life using the Arrhenius model.
Dharia Renate, Filli Pratama, Kiki Yuliati, Gatot Priyanto   +3 more
doaj   +1 more source

Combining Fret and Super‐Resolution Microscopy Reveals Kinase Activation and Mitochondrial Activity at the Nanoscale

Advanced Science, EarlyView.
BioSenSRRF is an open‐source workflow that combines conventional FRET biosensors with SRRF reconstruction to generate sub‐diffraction FRET index maps on standard microscopes. The pipeline integrates automated image registration, SRRF reconstruction, quantitative FRET index calculation, and random line‐based hotspot analysis to uncover AURKA‐dependent ...
Nicolas Y. Jolivet, Pierre‐Jean Desmaison, Xavier Pinson, Arthur Masson, Olivier Delalande, Giulia Bertolin   +5 more
wiley   +1 more source

Capsaicin Potentiates Anticancer Drug Efficacy Through Autophagy-Mediated Ribophorin II Downregulation and Necroptosis in Oral Squamous Cell Carcinoma Cells

Frontiers in Pharmacology, 2021
The ability of capsaicin co-treatment to sensitize cancer cells to anticancer drugs has been widely documented, but the detailed underlying mechanisms remain unknown.
Yi-Ching Huang, Tien-Ming Yuan, Bang-Hung Liu, Kai-Li Liu, Kai-Li Liu, Chiung-Hua Wung, Show-Mei Chuang   +6 more
doaj   +1 more source

Functional Disorder at the Neural Interface: How Disordered Nanostructures Promote Proper Growth and Differentiation in In Vitro Neural Cultures

Advanced Science, EarlyView.
This work provides a practical guide for neuroengineers to design advanced neural interfaces, embracing and tailoring the concept of functional disorder. By bridging 2D and 3D in vitro models, this work highlights how non‐periodic, spatially heterogeneous, multiscale nanotopography can enable more physiologically relevant platforms for studying neural ...
F. Maita, E. Palmieri, I. Lucarini, L. Montaina, L. Maiolo   +4 more
wiley   +1 more source

Experimental Evidence for Alleviating Nociceptive Hypersensitivity by Single Application of Capsaicin

Molecular Pain, 2015
The single application of high-concentration of capsaicin has been used as an analgesic therapy of persistent pain. However, its effectiveness and underlying mechanisms remain to be further evaluated with experimental approaches.
Xiao-Li Ma, Fang-Xiong Zhang, Fei Dong, Lan Bao, Xu Zhang   +4 more
doaj   +1 more source