International Journal of Nanomedicine, 2017 Xia-Rong Wang,1 Si-Qian Gao,1 Xiao-Qian Niu,1 Long-Jian Li,2 Xiao-Ying Ying,1 Zhong-Jie Hu,2 Jian-Qing Gao1,3 1Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 2Zhejiang Provincial Corps Hospital of Chinese ...
Wang XR +6 more
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Effects of Capsaicin on Biomimetic Membranes
Biomimetics, 2019 Capsaicin is a natural compound that produces a warm sensation and is known for its remarkable medicinal properties. Understanding the interaction between capsaicin with lipid membranes is essential to clarify the molecular mechanisms behind its ...
Neha Sharma +5 more
doaj +2 more sources
Effects of Selective Sphingosine‐1‐Phosphate Receptor 1 Agonist, TRV045, on Evoked Pain Tests: An Exploratory, Four‐Way Cross‐Over Study in Healthy Volunteers [PDF]
European Journal of Pain, Volume 30, Issue 6, July 2026.ABSTRACT Introduction Preclinical evidence suggests that dysregulation of the ceramide‐sphingosine‐1‐phosphate (S1P) axis may have analgesic properties. However, currently approved S1PR1 modulators such as fingolimod are hindered for this indication as they induce lymphopenia.
Wouter A. Bakker +9 more
wiley +2 more sources
Capsaicin treatment attenuates cholangiocarcinoma carcinogenesis.
PLoS ONE, 2014 UnlabelledCapsaicin, the most abundant pungent molecule produced by pepper plants, represents an important ingredient in spicy foods consumed throughout the world.
Annika Wutka +10 more
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Capsaicin: Emerging Pharmacological and Therapeutic Insights
Current Issues in Molecular BiologyCapsaicin, the most prominent pungent compound of chilli peppers, has been used in traditional medicine systems for centuries; it already has a number of established clinical and industrial applications.
Elena Madalina Petran +14 more
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Gut microbiota-dependent 24-hydroxycholesterol metabolism contributes to capsaicin-induced amelioration of Alzheimer’s disease-like pathology in mice [PDF]
Nature CommunicationsDietary capsaicin intake appears to affect the pathogenesis of Alzheimer’s disease (AD), while the underlying mechanisms remain unclear. Here, we found in human cohorts that moderate-to-high level of dietary capsaicin intake was associated with improved ...
Yawen Li +27 more
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Journal of Pain Research, 2014 Kun Zhang,1 Somayaji Ramamurthy,1 Thomas J Prihoda,2 Maxim S Eckmann1 1Department of Anesthesiology, 2Department of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA Purpose: The current study was designed to ...
Zhang K +3 more
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Activation of TREK‐1 and TREK‐2 Two‐Pore Domain Potassium Channels by the Kv4 Channel Modulator, NS5806 [PDF]
Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.ABSTRACT NS5806 is a diaryl‐urea small molecule developed for the treatment of pain and neurological disorders. A potent activator of Kv4.3 potassium channels, it is widely used to study Kv4 channel physiology in excitable cells, including trigeminal neurons.
E. L. Veale +4 more
wiley +2 more sources
Effect of Capsaicin (8%) Topical System on Sensory Function in Patients With Diabetic Peripheral Neuropathy: Analysis of the PACE Study [PDF]
Muscle &Nerve, Volume 73, Issue 6, Page 1109-1117, June 2026.This graphical abstract provides a summary of the analysis of the PACE study that evaluated the effect of high‐concentration capsaicin topical system (HCCTS) on sensory function in patients with DPN. From left to right: Progression of untreated DPN; Research question for current analysis; Outcomes used to evaluate sensory function; Intervention; Main ...
Nathaniel P. Katz +4 more
wiley +2 more sources
Capsaicin: A Potential Treatment to Improve Cerebrovascular Function and Cognition in Obesity and Ageing [PDF]
, 2023 Impaired cognition is the primary symptom of dementia, which can lead to functional disability and reduced quality of life among an increasingly ageing population.
Tammy Thornton +5 more
core +1 more source