Results 21 to 30 of about 40,616 (253)

Contemporary management of pain in cirrhosis: Toward precision therapy for pain

Hepatology, EarlyView., 2022
Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman, Neehar Parikh, Dan J. Clauw, David A. Williams, Elliot B. Tapper   +4 more
wiley   +1 more source

Capsaicin Enhances Glutamatergic Synaptic Transmission to Neonatal Rat Hypoglossal Motor Neurons via a TRPV1-Independent Mechanism

Frontiers in Cellular Neuroscience, 2017
We investigated whether capsaicin modulated synaptic transmission to hypoglossal motor neurons (HMNs) by acting on transient receptor potential vanilloid type 1 (TRPV1) receptors.
Prajwal P. Thakre, Mark C. Bellingham
doaj   +1 more source

Capsaicin Potently Blocks Salmonella typhimurium Invasion of Vero Cells

Antibiotics, 2022
Salmonella typhimurium (S. typhimurium) is one of the major food and waterborne bacteria that causes several health outbreaks in the world. Although there are few antibiotics against this bacterium, some of these drugs are challenged with resistance and ...
Joseph A. Ayariga, Daniel A. Abugri, Balagopal Amrutha, Robert Villafane   +3 more
doaj   +1 more source

Capsaicin in metabolic syndrome [PDF]

, 2018
Capsaicin, the major active constituent of chilli, is an agonist on transient receptor potential vanilloid channel 1 (TRPV1). TRPV1 is present on many metabolically active tissues, making it a potentially relevant target for metabolic interventions ...
Lindsay Brown, Sunil Panchal, Panchal, Sunil K., Edward Bliss, Brown, Lindsay, Panchal, Sunil K, Bliss, Edward, Panchal, Sunil K. (R20071), Bliss, Edward S., Sunil K. Panchal   +9 more
core   +1 more source

Capsaicin Acts Through Reducing P38 MAPK-Dependent Thymidylate Synthase Expression to Enhance 5-Fluorouracil-Induced Cytotoxicity in Human Lung Cancer Cells

Natural Product Communications, 2021
Capsaicin, an ingredient of green and red bell peppers, shows anticancer activity in several malignant cell lines. Thymidylate synthase (TS) is a well-validated anticancer drug target in non-small cell lung cancer (NSCLC) cells.
Chun-Liang Tung, Jyh-Cheng Chen, Jen-Chung Ko, Li-Ling Liu, Chin-Cheng Chien, I-Hsiang Huang, Yong-Cing Tsao, Hsiang-Hung Cheng, Tzu-Ying Chen, Ting-Chuan Yen, Yun-Wei Lin   +10 more
doaj   +1 more source

Resilience to capsaicin-induced mitochondrial damage in trigeminal ganglion neurons

Molecular Pain, 2020
Capsaicin is an agonist of transient receptor potential cation channel subfamily V member 1 (TRPV1). Strong TRPV1 stimulation with capsaicin causes mitochondrial damage in primary sensory neurons.
Mamoru Shibata, Yohei Kayama, Tsubasa Takizawa, Keiji Ibata, Toshihiko Shimizu, Michisuke Yuzaki, Norihiro Suzuki, Jin Nakahara   +7 more
doaj   +1 more source

The Mysteries of Capsaicin-Sensitive Afferents

Frontiers in Physiology, 2020
A fundamental subdivision of nociceptive sensory neurons is named after their unique sensitivity to capsaicin, the pungent ingredient in hot chili peppers: these are the capsaicin-sensitive afferents.
Michael J. M. Fischer, Cosmin I. Ciotu, Arpad Szallasi   +2 more
doaj   +1 more source

Effects of Capsaicin on Adipogenic Differentiation in Bovine Bone Marrow Mesenchymal Stem Cell [PDF]

Asian-Australasian Journal of Animal Sciences, 2014
Capsaicin is a major constituent of hot chili peppers that influences lipid metabolism in animals. In this study, we explored the effects of capsaicin on adipogenic differentiation of bovine bone marrow mesenchymal stem cells (BMSCs) in a dose- and time ...
Jin Young Jeong, Sekar Suresh, Mi Na Park, Mi Jang, Sungkwon Park, Kuppannan Gobianand, Seungkwon You, Sung-Heom Yeon, Hyun-Jeong Lee   +8 more
doaj   +1 more source

Enhanced Anti-Inflammatory Effects of Silibinin and Capsaicin Combination in Lipopolysaccharide-Induced RAW264.7 Cells by Inhibiting NF-κB and MAPK Activation

Frontiers in Chemistry, 2022
Silibinin and capsaicin both are natural product molecules with diverse biological activities. In this article, we investigated the anti-inflammatory effects of silibinin combined with capsaicin in lipopolysaccharide (LPS)-induced RAW264.7 cells.
Yingying Zheng, Jie Chen, Xiaozheng Wu, Xin Zhang, Chunmei Hu, Yu Kang, Jing Lin, Jiamin Li, Yuechang Huang, Xingmin Zhang, Chen Li   +10 more
doaj   +1 more source

In vitro Anti-Helicobacter pylori Activity of Capsaicin

, 2020
Worldwide, peptic ulcer and gastritis considered to be one ofthe biggest health challenge, Helicobacter pylori is responsible for more than eighty percent of chronic active gastritis where continual infection remains for decennary. However, the success
Luay Abu-Qatouseh, Nehaya ALKarabieh, Ali Al-Samydai, Isra Tayseer, Talal Aburjai, Wesam Ahmed   +5 more
core   +1 more source