Harnessing the Therapeutic Potential of Capsaicin and Its Analogues in Pain and Other Diseases
Molecules, 2016 Capsaicin is the most predominant and naturally occurring alkamide found in Capsicum fruits. Since its discovery in the 19th century, the therapeutic roles of capsaicin have been well characterized. The potential applications of capsaicin range from food
Shaherin Basith +3 more
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Targeting CXCR2 in Nociceptive Sensory Neurons Offers Novel Therapeutic Potentials for Postoperative Pain. [PDF]
Adv Sci (Weinh)Tissue incision induces CXCL5 release, which activates neuronal CXCR2 on incision‐innervating sensory neurons. Neuronal CXCR2 couples with TRPA1 to drive mechanical pain and engages p38 MAPK signaling to upregulate TRPV1 and promote heat pain. Targeted Cxcr2 knockdown relieves incisional pain while preserving CXCR2‐dependent neutrophil responses ...
Pan Y +10 more
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Effects of Capsaicin on Adipogenic Differentiation in Bovine Bone Marrow Mesenchymal Stem Cell [PDF]
Asian-Australasian Journal of Animal Sciences, 2014 Capsaicin is a major constituent of hot chili peppers that influences lipid metabolism in animals. In this study, we explored the effects of capsaicin on adipogenic differentiation of bovine bone marrow mesenchymal stem cells (BMSCs) in a dose- and time ...
Jin Young Jeong +8 more
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TGF-β1 Directly Sensitizes Capsaicin-Sensitive Lung Vagal Neurons to Promote Airway Hypersensitivity. [PDF]
Acta Physiol (Oxf)ABSTRACT Aim Transforming growth factor‐β1 (TGF‐β1) is a pleiotropic cytokine implicated in the pathogenesis of inflammatory airway diseases such as asthma. Airway hypersensitivity (AHS), arising from sensitization of capsaicin‐sensitive lung vagal (CSLV) afferents, is a hallmark of these airway diseases.
Chen YY, Chan NJ, Hsu CC.
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The Mysteries of Capsaicin-Sensitive Afferents
Frontiers in Physiology, 2020 A fundamental subdivision of nociceptive sensory neurons is named after their unique sensitivity to capsaicin, the pungent ingredient in hot chili peppers: these are the capsaicin-sensitive afferents.
Michael J. M. Fischer +2 more
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Resilience to capsaicin-induced mitochondrial damage in trigeminal ganglion neurons
Molecular Pain, 2020 Capsaicin is an agonist of transient receptor potential cation channel subfamily V member 1 (TRPV1). Strong TRPV1 stimulation with capsaicin causes mitochondrial damage in primary sensory neurons.
Mamoru Shibata +7 more
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Frontiers in Chemistry, 2022 Silibinin and capsaicin both are natural product molecules with diverse biological activities. In this article, we investigated the anti-inflammatory effects of silibinin combined with capsaicin in lipopolysaccharide (LPS)-induced RAW264.7 cells.
Yingying Zheng +10 more
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Differences in the Control of Secondary Peristalsis in the Human Esophagus: Influence of the 5-HT4 Receptor versus the TRPV1 Receptor. [PDF]
PLoS ONE, 2016 Acute administration of 5-hydroxytryptamine4 (5-HT4) receptor agonist, mosapride or esophageal infusion of the transient receptor potential vanilloid receptor-1 (TRPV1) agonist capsaicin promotes secondary peristalsis.
Chih-Hsun Yi +6 more
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Effects of Mono- and Dicapsaicinoid Functionalization on the Physicochemical Properties and Antimicrobial Photodynamic Activity of Protoporphyrin IX. [PDF]
ChemMedChemCapsaicin functionalization of Protoporphyrin IX influences aggregation behavior, lipophilicity, and photodynamic activity. A monosubstituted derivative exhibits enhanced antimicrobial photoinactivation of Staphylococcus aureus, whereas increased functionalization does not improve efficacy.
Cunha IVD +10 more
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Nature Communications, 2018 The capsaicin receptor TRPV1 has been structurally characterized, but the capsaicin activation dynamics remain elusive. Here authors use fluorescent unnatural amino acid incorporation, computational modeling and Φ-analysis to derive the capsaicin-bound ...
Fan Yang +6 more
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