Results 51 to 60 of about 29,187 (199)
The Modern Law Review, EarlyView.This case note critically examines the January 2026 High Court judgment in The King (on the application of The Howard League for Penal Reform) v The Secretary of State for Justice which dismissed a judicial review challenging the expansion of the use of PAVA spray in Young Offender Institutions (YOIs) in England.
Raymond Arthur
wiley +1 more source
Surgical Management of Non‐Allergic Rhinitis—An EAACI Task Force Position Paper
Allergy, EarlyView.ABSTRACT Non‐allergic rhinitis is a frequent yet underdiagnosed cause of chronic nasal symptoms, including nasal congestion, rhinorrhoea, and upper airway hyperreactivity. Its pathophysiology involves neurogenic dysregulation, leading to excessive mucus production and vasodilation.
Marie Lundberg +18 more
wiley +1 more source
Molecular Pain, 2017 Intradermally injected capsaicin induces secondary mechanical hyperalgesia and allodynia outside the primary (i.e., capsaicin-injected) site. This secondary mechanical hypersensitivity is attributed to central sensitization in which reactive oxygen ...
Jun-Ho La +5 more
doaj +1 more source
Journal of Pharmacological Sciences, 2003 A segment of guinea pig ileum was used to confirm the hypothesis that [6]-gingerol and lafutidine interact with capsaicin-sensitive neurons. Addition of 30 and 100 μM [6]-gingerol (a pungent constituent of ginger) induced contraction of the ileum ...
Akiyoshi Someya +3 more
doaj +1 more source
Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?
British Journal of Pharmacology, EarlyView.Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli +7 more
wiley +1 more source
Capsaicin and carcinogenesis. Conflicting evidence regarding effects on carcinogenesis [PDF]
Farmacja PolskaStudy subject. Effect of capsaicin on tumorigenesis. Plants of the Capsicum family including chili peppers are one of the oldest domesticated crops. The constituents of chili peppers, particularly capsaicin, have become the subject of intense research ...
Krzysztof Mariusz Halczuk +1 more
doaj +1 more source
Novel approaches for drug development against chronic primary pain: A systematic review
British Journal of Pharmacology, EarlyView.Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus +5 more
wiley +1 more source
Molecular Pain, 2018 Transient receptor potential vanilloid 1 (TRPV1) is a nonselective cation channel that is expressed in the sensory neurons and responds to various noxious stimuli including heat and capsaicin. The molecular properties of TRPV1 have been clearly examined;
Nozomu Okamoto +5 more
doaj +1 more source
Acidification of rat TRPV1 alters the kinetics of capsaicin responses
Molecular Pain, 2005 TRPV1 (vanilloid receptor 1) receptors are activated by a variety of ligands such as capsaicin, as well as by acidic conditions and temperatures above 42°C.
Faltynek Connie R +4 more
doaj +1 more source
Cancer pain: current practice and emerging targets
British Journal of Pharmacology, EarlyView.Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye +5 more
wiley +1 more source