Results 71 to 80 of about 29,187 (199)

Modulation of Capsaicin-Evoked Visceral Pain and Referred Hyperalgesia by Protease-Activated Receptors 1 and 2

Journal of Pharmacological Sciences, 2004
Protease-activated receptors (PARs) 1 and 2 are expressed in capsaicin-sensitive sensory neurons, being anti- and pro-nociceptive, respectively. Given the possible cross talk between PAR-2 and capsaicin receptors, we investigated if PAR-2 activation ...
Naoyuki Kawao, Hisao Ikeda, Tomoko Kitano, Ryotaro Kuroda, Fumiko Sekiguchi, Kazuo Kataoka, Yoshihisa Kamanaka, Atsufumi Kawabata   +7 more
doaj   +1 more source

Bridging gaps in diabetic neuropathy care: A Delphi‐based regional consensus from the Gulf Cooperation Council

Journal of Diabetes Investigation, EarlyView.
A three‐round Delphi consensus developed GCC‐specific, evidence‐based recommendations for diabetic peripheral neuropathy (DPN) and painful diabetic neuropathy (PND). The consensus emphasizes proactive screening, early multimodal management, and addressing regional barriers to improve early detection, optimize management, and enhance quality of life ...
Abdulrahman Alshaikh, Abdulnabi T Alattar, Ahmed Abdul Karim Hassoun, Afaf Alshammary, Hussein Elbadawi, Khaled Aldossari, Noor Al Busaidi, Saud Alsifri, Talal Muzaffar, Wiam I. Hussein, Christine Talaat, Abanoub Effat, Marwa Elsaghier, Rayaz A Malik   +13 more
wiley   +1 more source

The Antiproliferative and Apoptotic Effects of Capsaicin on an Oral Squamous Cancer Cell Line of Asian Origin, ORL-48

Medicina, 2019
Background and Objectives: The antitumor activities of capsaicin on various types of cancer cell lines have been reported but the effect of capsaicin on oral cancer, which is prevalent among Asians, are very limited. Thus, this study aimed to investigate
Mohammad Firdaus Kamaruddin, Mohammad Zakir Hossain, Aied Mohamed Alabsi, Marina Mohd Bakri   +3 more
doaj   +1 more source

Pathophysiology and emerging treatments for dermographic, cholinergic and cold urticaria

Journal of the European Academy of Dermatology and Venereology, EarlyView.
This review illustrates key proposed mast cell‐mediated activation pathways in dermographic, cholinergic and cold urticaria, highlighting IgE‐dependent and ‐independent mechanisms. These pathways are increasingly targeted by emerging drugs, aiming to interrupt mast cell activation and mediator release, offering more precise, mechanism‐based treatment ...
Mojca Bizjak‐Suran, Matjaž Fležar, Manuel Pedro Pereira   +2 more
wiley   +1 more source

Exploring the effect of capsaicin on gene expression and chemotherapy sensitization in gastric cancer cells

European Journal of Medical Research
Background Capsaicin, phytochemical component in red hot chili peppers, has previously been demonstrated to exhibit antitumor effect in various cancer type.
Weijian Meng, Kun Xie, Zhihong Qi, Rui Zhang, Jie Shen   +4 more
doaj   +1 more source

Effects of oral stimulation with capsaicin on salivary secretion and neural activities in the autonomic system and the brain

Journal of Dental Sciences, 2018
Background/purpose: Although it has been reported that capsaicin ingestion has effects of protecting stomach mucosa and promoting energy consumption, physiological responses to oral stimulation with capsaicin has not been elucidated.
Yoko Kono, Ayako Kubota, Masato Taira, Narumi Katsuyama, Kumiko Sugimoto   +4 more
doaj   +1 more source

Genomic variation drives plant flavor diversification

Journal of Integrative Plant Biology, EarlyView.
This review explains how genomic variation shapes plant flavor by altering the biosynthetic and regulatory pathways of key attributes like sweetness, acidity, bitterness, piquancy, astringency, and aroma. It also discusses how multi‐omics, AI‐assisted breeding, and gene editing can translate this knowledge into plants with improved flavor, nutrition ...
Huimin Hu, Yanwei Hao, Yiwei Zhou, Xia Zhang, Rui Xia, Pan Liao   +5 more
wiley   +1 more source

Comparative Study of Clinical Characteristics According to Pain Distribution in Lingual Burning Mouth Syndrome

Journal of Oral Rehabilitation, EarlyView.
Tongue pain mapping in 256 patients with lingual burning mouth syndrome identified distinct clinical phenotypes according to pain distribution. Wider pain areas were associated with higher pain intensity and poorer oral health‐related quality of life, supporting individualised assessment and targeted management.
Yoohyun Sim, Na‐Yeon Ha, Seok‐Jae Ko, Jae‐Woo Park, Jinsung Kim   +4 more
wiley   +1 more source

Is Capsaicin Effective in Relieving the Symptoms of Burning Mouth Syndrome? A Systematic Review

Journal of Oral Rehabilitation, EarlyView.
The capsaicin, administered topically or systemically, reduces pain symptoms in patients with Burning Mouth Syndrome (BMS). However, despite consistent clinical improvement, the current evidence is limited and of low certainty, highlighting the need for well‐designed studies to confirm its effectiveness. ABSTRACT Background Burning Mouth Syndrome (BMS)
Ana Paula de Andrade Silva, Ian Wesley Rocha dos Santos, Zuleni Alexandre da Silva, Deborah Ribeiro Frazão, José Mário Matos‐Sousa, Wallacy Watson Pereira Melo, Rafael Rodrigues Lima, Renata Duarte de Souza‐Rodrigues   +7 more
wiley   +1 more source

Innovations in Obesity Treatment: Beyond Adipose Tissue Dysfunction

Obesity Reviews, EarlyView.
Obesity drives chronic inflammation, insulin resistance, type 2 diabetes, and cancer development through adipocyte dysfunction. Addressing this multisystemic disorder requires integrated strategies beyond diet and exercise, such as thermogenesis activation via menthol or capsinoids and appetite control through GLP‐1/GIP agonists and neuromodulation to ...
Jesica Martínez‐Godfrey, Irene Pomares‐Bri, Paula de Juan‐Maciá, Mariló Olivares‐Vicente, Enrique Barrajón‐Catalán, Vicente Micol, Enrique Roche, María Herranz‐López   +7 more
wiley   +1 more source