Results 81 to 90 of about 40,616 (253)
, 1996 Previous studies with the vanilloid spice principle capsaicin have demonstrated a biphasic VO 2 response, with vasoconstriction, in the perfused rat hindlimb that has led to suggestions of vanilloid receptor subtypes (VN 1/VN 2) in this preparation (1 ...
Eldershaw, TPD (15476804) +4 more
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Frontiers in Physiology, 2017 Background: The effects of capsaicin on obesity and glucose homeostasis are still controversial and the mechanisms underlying these effects remain largely unknown.
Jun-Xian Song +23 more
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Capsaicin suppresses liver fat accumulation in high-fat diet-induced NAFLD mice
Animal Cells and Systems, 2020 Dietary capsaicin exhibits anti-steatosis activity in obese mice. High-fat diet (HFD)-induced mice is a highly studied approach to develop non-alcoholic fatty liver disease (NAFLD).
Mi Kyung Shin, Soo-Man Yang, In-Seob Han
doaj +1 more source
Cancer pain: current practice and emerging targets
British Journal of Pharmacology, EarlyView.Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye +5 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.Abstract Opioids are prescribed widely for chronic pain despite well‐recognised risks and variable long‐term benefit, reflecting the lack of effective alternatives for many patients. Combination therapies offer a promising strategy to enhance efficacy whilst reducing side effects.
André Mouraux +26 more
wiley +1 more source
Capsaicin Entrapment in Metal-Organic Framework Material Derived from γ-Cyclodextrin
, 2019 Capsaicin, a pungent molecule from red chilli is known for its therapeutic benefits. However, poor aqueous solubility coupled with inherent pungency has limited its applications.
Nisha kiran, Meena +3 more
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Membrane Interactivity of Capsaicin Antagonized by Capsazepine
, 2022 Although the pharmacological activity of capsaicin has been explained by its specific binding to transient receptor potential vanilloid type 1, the amphiphilic structure of capsaicin may enable it to act on lipid bilayers.
Maki Mizogami, Hironori Tsuchiya
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British Journal of Pharmacology, EarlyView.Transient receptor potential vanilloid 1 (TRPV1) was the first noxious heat‐sensitive channel discovered. In rodents, its role is robust in the heat response of the cell body of polymodal nociceptors, but surprisingly small in that of the peripheral terminals in the skin.
Gábor Pethő, Peter W. Reeh
wiley +1 more source
Sensors, 2013 Chili hotness is very much dependent on the concentration of capsaicin present in the chili fruit. A new biosensor based on a horseradish peroxidase enzyme-capsaicin reaction mediated by ferrocene has been successfully developed for the amperometric ...
Lee Yook Heng +2 more
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