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Results 91 to 100 of about 29,187 (199)

Low‐threshold cutaneous mechanoreceptors on the foot sole have enhanced sensitivity when skin temperature is elevated

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic illustration of microneurography recordings used to examine the effects of local skin heating on cutaneous mechanoreceptor responses in the human foot (left panel). A microelectrode inserted into a peripheral nerve records single‐unit activity from tactile afferent fibres while controlled mechanical stimuli are applied ...
Erika E. Howe +4 more
wiley +1 more source

Capsaicin-induced TRIB3 upregulation promotes apoptosis in cancer cells

Cancer Management and Research, 2018
Rong-Jaan Lin,1,2 I-Jung Wu,1,2 Jo-Yu Hong,3 Bang-Hung Liu,4 Ruei-Yue Liang,4 Tein-Ming Yuan,5 Show-Mei Chuang4,6,7 1College of Life Sciences, National Chung Hsing University, 2Taichung Hospital, Ministry of Health and Welfare, 3Bachelor Program of ...
Lin RJ +6 more
doaj

Advances in Chitosan Nanoparticles: A Comprehensive Review of Properties, Synthesis, Characterization, Multidisciplinary Applications, and Future Perspectives

Journal of Applied Polymer Science, Volume 143, Issue 33, September 5, 2026.
This review highlights the synthesis of chitosan nanoparticles from natural sources, the thorough characterization of them, and use of microscopic and spectroscopic methods. It emphasizes that it has some indispensable properties such as being non‐toxic, antimicrobial, and capable of controlled drug release.
Mariam Sohail Mansoor +6 more
wiley +1 more source

Climate‐smart Naga chili (Capsicum chinense Jacq.) cultivation: Adapting fertilizer and irrigation practices for changing climate

Agrosystems, Geosciences &Environment, Volume 9, Issue 3, September 2026.
Abstract Limited winter rainfall and rising irrigation costs threaten sustainable Naga chili (Capsicum chinense Jacq.) production in Bangladesh. However, the combined effects of crop‐specific irrigation and soil‐test‐based fertilization on Naga chili productivity and resource‐use efficiency remain poorly understood.
Rasendra Talukder +4 more
wiley +1 more source

Molecular Mechanisms of Food Bioactive Constituents in the Management of Obesity and Hypertension: A Critical Review

Phytochemicals in Food and Medicine, Volume 1, Issue 3, September 2026.
Obesity and hypertension co‐exist and share molecular mechanisms in terms of dietary therapy, modulated by food bioactive constituents. ABSTRACT Obesity and hypertension are among the most pressing global public health challenges. They frequently co‐exist, with obesity‐related hypertension accounting for an estimated 75% of the hypertension burden ...
Samuel Oluwasegun Maccarthy +3 more
wiley +1 more source

Peripheral κ opioid receptor in pain and inflammation: From molecular signalling and gene expression to drug discovery

British Journal of Pharmacology, Volume 183, Issue 17, Page 5157-5189, September 2026.
The κ opioid receptor (κ receptor, KOR) is a G protein‐coupled receptor with well established roles in analgesia and immune modulation. Although historically studied primarily in the central nervous system (CNS), growing evidence indicates that κ signalling in peripheral tissues plays an important role in regulating pain, inflammation and immune ...
Rumsha Khan +3 more
wiley +1 more source

Heart‐Specific Spinal and Vagal Afferents: Transcriptomic Signatures and Optogenetically Modulated Functional Coupling With Cardiomyocytes

Comprehensive Physiology, Volume 16, Issue 4, August 2026.
Selective purification of heart‐specific spinal and vagal sensory neurons by retrograde labeling and FACS purification showed enhanced spontaneous, optogenetic, and chemically stimulated Ca2+ activity. Transcriptomic profiling identified distinct ion channel and GPCR signatures in heart‐specific sensory neurons.
T. Akgul Caglar +8 more
wiley +1 more source

Medications That Regulate Pregnane X Receptor: A Systematic Review of Current Evidence

Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
PRISMA 2020 flow diagram of study selection for this systematic review of medications that regulate the pregnane X receptor (PXR), from 12 236 records screened to 101 included studies. ABSTRACT The pregnane X receptor (PXR) gene encodes a ligand‐activated protein involved with the metabolism and excretion of drugs, toxins, and other xenobiotics.
Petra Czarniak +4 more
wiley +1 more source

Metal‐Based Materials for Redox Modulation in Biomedicine

Rare Metals, Volume 45, Issue 8, August 2026.
ABSTRACT Metal materials have become increasingly important in modulating biological redox networks for therapeutic and diagnostic purposes, owing to their distinctive electronic properties and adaptable reactivity. This review synthesizes recent developments across various metal‐based materials, including elemental metals, metal oxides, coordination ...
Yan Fan +7 more
wiley +1 more source

Patient‐reported outcomes, postoperative pain and pain relief after day‐case surgery (POPPY): short‐term peri‐operative analgesic use

Anaesthesia, Volume 81, Issue 8, Page 1057-1067, August 2026.
Summary Introduction An increasing proportion of complex surgical procedures are being performed in the UK as day‐cases, with variable and limited follow up. Discharge prescriptions must provide adequate analgesia, while considering the safety of the patient and public, following best practice guidance and good opioid stewardship.
Anna Ratcliffe +2083 more
wiley +1 more source

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