Results 61 to 70 of about 44,345 (223)

The Translational Studies of Pain: From Spinal Neurones to Human Perception [PDF]

open access: yes, 2015
The discovery of new treatments for chronic pain relies on the detection of pre-clinical targets and the progression to successful clinical trials. In order to improve this transition reliable translational models must be identified, based on mechanisms ...
O'Neill, J
core  

The impact of topical capsaicin application on the muscle metaboreflex and microvascular responsiveness

open access: yesPhysiological Reports
Topical capsaicin reduces metaboreflex responses during post‐exercise circulatory arrest (PECA) in males, but its effects in females and on microvascular responsiveness in either sex remain unclear.
Nikolaus D. Carpenter   +4 more
doaj   +1 more source

Laryngeal Cryotherapy for Neurogenic Cough: Safety, Feasibility, and Prospective Outcomes

open access: yesThe Laryngoscope, EarlyView.
A prospective clinical trial investigated the safety and clinical outcomes of office‐based selective laryngeal cryotherapy for patients with refractory chronic cough. Patient were followed for 6 months posttreatment and had durable improvement in cough severity index and urge‐to‐cough scores and no serious long term adverse effects.
Shumon I. Dhar   +6 more
wiley   +1 more source

Research progress of capsaicin application in broiler production

open access: yesSiliao yanjiu, 2022
Capsaicin has obvious antibacterial and anti-inflammatory effects, which can improve the growth performance of broilers, improve immunity, promote intestinal development. Capsaicin has potential value of replacing antibiotics in poultry breeding industry.
DAI Bing, WU Bing
doaj  

Late INa as a Therapeutic Target: New Strategies, Computational Modelling, Drug Development, and Clinical Translation

open access: yesMedicinal Research Reviews, EarlyView.
ABSTRACT The Nav1.5 channel, a major isoform of voltage‐gated sodium ion channel, is mainly found in ventricular cardiomyocytes, playing a key role in generating essential cardiac action potentials for normal heart rhythms. Mutations in Nav1.5 have been associated with severe heart conditions such as long QT syndrome, Brugada syndrome, cardiac ...
Arkapravo Chattopadhyay   +3 more
wiley   +1 more source

Capsaicin Entrapment in Metal-Organic Framework Material Derived from γ-Cyclodextrin [PDF]

open access: yes, 2019
Capsaicin, a pungent molecule from red chilli is known for its therapeutic benefits. However, poor aqueous solubility coupled with inherent pungency has limited its applications.
Nisha kiran, Meena   +3 more
core   +1 more source

Efficacy of deterrents in minimizing nontarget species consumption of bait used for attracting wild pigs (Sus scrofa)

open access: yesPest Management Science, EarlyView.
Evaluated repellents were effective at deterring white‐tailed deer from consuming wild pig bait piles without deterring wild pig bait consumption, although the deterrents were not effective for other nontarget wildlife. Abstract BACKGROUND Wild pigs (Sus scrofa) are an invasive species that cause environmental and agricultural damage.
Caitlin A Kupferman   +3 more
wiley   +1 more source

Capsaicin in the Periaqueductal Gray Induces Analgesia Via Metabotropic Glutamate Receptor-Mediated Endocannabinoid Retrograde Disinhibition

open access: yes, 2012
BACKGROUND AND PURPOSE Capsaicin, an agonist of transient receptor potential vanilloid 1 TRPV1 channels, is pro- nociceptive in the periphery but is anti-nociceptive when administered into the ventrolateral periaqueductal gray vlPAG, a midbrain region ...
LIAO, HSIN-TZU;CHIOU, LIH-CHU   +1 more
core  

Transcriptome Inference and Systematic Approaches to Investigate TCM Compounds With Beneficial Metabolic Effects

open access: yesPhytotherapy Research, EarlyView.
ABSTRACT Obesity is a major risk factor for type 2 diabetes. Some traditional Chinese medicine (TCM) compounds can improve obesity by increasing energy consumption. This study aimed to identify and verify TCM compounds that promote adipose thermogenesis to alleviate obesity via transcriptomic analysis, molecular docking, network pharmacology, and ...
Jing Li   +6 more
wiley   +1 more source

Differential involvement of reactive oxygen species in a mouse model of capsaicin-induced secondary mechanical hyperalgesia and allodynia

open access: yesMolecular Pain, 2017
Intradermally injected capsaicin induces secondary mechanical hyperalgesia and allodynia outside the primary (i.e., capsaicin-injected) site. This secondary mechanical hypersensitivity is attributed to central sensitization in which reactive oxygen ...
Jun-Ho La   +5 more
doaj   +1 more source

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