TRPV4, TRPC1, and TRPP2 assemble to form a flow-sensitive heteromeric channel [PDF]
, 2014 Transient receptor potential (TRP) channels, a superfamily of ion channels, can be divided into 7 subfamilies, including TRPV, TRPC, TRPP, and 4 others. Functional TRP channels are tetrameric complexes consisting of 4 pore-forming subunits.
Birnbaumer, Lutz +5 more
core +1 more source
Generators of Pressure-Evoked Currents in Vertebrate Outer Retinal Neurons
Cells, 2021 (1) Background: High-tension glaucoma damages the peripheral vision dominated by rods. How mechanosensitive channels (MSCs) in the outer retina mediate pressure responses is unclear. (2) Methods: Immunocytochemistry, patch clamp, and channel fluorescence
Ji-Jie Pang, Fan Gao, Samuel M. Wu
doaj +1 more source
The Basal Thermal Sensitivity of the TRPV1 Ion Channel Is Determined by PKCβII [PDF]
, 2014 Copyright © 2014 the authors 0270-6474/14/348246-13$15.00/0.Peer reviewedPublisher ...
Hasan, Raquibul, Li, Lin, Zhang, Xuming
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TRP Channels Entering the Structural Era [PDF]
, 2013 Transient receptor potential (TRP) channels are important in many neuronal and non-neuronal physiological processes. The past 2 years have seen much progress in the use of structural biology techniques to elucidate molecular mechanisms of TRP channel ...
Gaudet, Rachelle
core +1 more source
Expression of transient receptor potential vanilloid (TRPV) channels in different passages of articular chondrocytes [PDF]
, 2012 Ion channels play important roles in chondrocyte mechanotransduction. The transient receptor potential vanilloid (TRPV) subfamily of ion channels consists of six members.
Barrett-Jolley, Richard +4 more
core +3 more sources
Structural and Biochemical Consequences of Disease-Causing Mutations in the Ankyrin Repeat Domain of the Human TRPV4 Channel [PDF]
, 2014 The TRPV4 calcium-permeable cation channel plays important physiological roles in osmosensation, mechanosensation, cell barrier formation, and bone homeostasis. Recent studies reported that mutations in TRPV4, including some in its ankyrin repeat domain (
Gaudet, Rachelle +3 more
core +2 more sources
Quantitative Real-Time PCR Detection of TRPV1–4 Gene Expression in Human Leukocytes from Healthy and Hyposensitive Subjects [PDF]
, 2008 BACKGROUND: Besides functioning as chemosensors for a broad range of endogenous and synthetic ligands, transient receptor potential vanilloid (TRPV) 1-4 channels have also been related to capsaicin (TRPV1), pain, and thermal stimuli perception, and ...
Giacomo Spinsanti +7 more
core +1 more source
Pharmacological Or Genetic Targeting Of Transient Receptor Potential (TRP) Channels Can Disrupt The Planarian Escape Response [PDF]
, 2019 In response to noxious stimuli, planarians cease their typical ciliary gliding and exhibit an oscillatory type of locomotion called scrunching. We have previously characterized the biomechanics of scrunching and shown that it is induced by specific ...
Cochet-Escartin, O. +5 more
core +4 more sources
What do we know about the transient receptor potential vanilloid 2 (TRPV2) ion channel? [PDF]
, 2013 Transient receptor potential (TRP) ion channels are emerging as a new set of membrane proteins involved in a vast array of cellular processes and regulated by a large number of physical and chemical stimuli, which involves them with sensory cell ...
Doñate-Macian, Pau +2 more
core +1 more source
BMC Genomics, 2006 Background The purpose of this work was to study the gene expression of transient receptor potential (TRP) channels in the mouse. The application of a standardized and quantitative technique, TaqMan RT-PCR, should give information about the pattern and ...
Krüger Jana +3 more
doaj +1 more source