Results 51 to 60 of about 238 (118)

Pharmacology of vanilloid transient receptor potential cation channels

, 2009
Depending on their primary structure, the 28 mammalian transient receptor potential (TRP) cation channels identified so far can be sorted into 6 subfamilies: TRPC ("Canonical"), TRPV ("Vanilloid"), TRPM ("Melastatin"), TRPP ("Polycystin"), TRPML ...
Appendino, Giovanni, Nilius, Bernd, Vriens, Joris   +2 more
core   +1 more source

Stimulation of TRPV1 by green laser light [PDF]

, 2012
Low-level laser irradiation of visible light had been introduced as a medical treatment already more than 40 years ago, but its medical application still remains controversial.
Wang, Lina, Schwarz, Wolfgang, Huang, Fang, Gu, Quanbao   +3 more
core   +1 more source

The role of TRP proteins in mast cells

Frontiers in Immunology, 2012
TRP proteins form cation channels that are regulated through strikingly diverse mechanisms including multiple cell surface receptors, changes in temperature, in pH and osmolarity, in cytosolic Ca2+ concentration ([Ca2+]i) and by phosphoinositides. The 28
Marc eFreichel, Julia eAlmering, Volodymyr eTsvilovskyy   +2 more
doaj   +1 more source

The Thoracic Lymphatic Vasculature: Interorgan Strategies to Achieve an Optimal Tissue Function

Comprehensive Physiology, Volume 16, Issue 2, April 2026.
In the thorax, organ‐specific features such as stomata and submesothelial lacunae, pulmonary perivascular and peribronchial vessels, and subepicardial lymphatic network allow the thoracic lymphatics to perform as a dynamically regulated system able to exploit local mechanical forces and tissue‐specific architecture to maintain fluid and solute ...
Daniela Negrini, Eleonora Solari, Cristiana Marcozzi, Andrea Moriondo   +3 more
wiley   +1 more source

Transient Receptor Potential Vanilloid 1 Expression Mediates Capsaicin-Induced Cell Death

Frontiers in Physiology, 2018
The transient receptor potential (TRP) ion channel family consists of a broad variety of non-selective cation channels that integrate environmental physicochemical signals for dynamic homeostatic control.
Ricardo Ramírez-Barrantes, Claudio Córdova, Sebastian Gatica, Sebastian Gatica, Belén Rodriguez, Carlo Lozano, Ivanny Marchant, Cesar Echeverria, Felipe Simon, Felipe Simon, Pablo Olivero   +10 more
doaj   +1 more source

Bidirectional Roles of TRPV1 in a Latent Sensitization Model of Myofascial Low Back Pain

European Journal of Pain, Volume 30, Issue 4, April 2026.
ABSTRACT Introduction Chronic primary low back pain (cpLBP) is a global health concern with poorly understood pathomechanisms, potentially involving spinal sensitization. The capsaicin receptor TRPV1 plays a crucial role in sensitization across pain models.
Vivian Blechschmidt, Bastian Schlickenrieder, Jonathan R. Husk, Ulrich Hoheisel, Handan Mörz, Rolf‐Detlef Treede, Wolfgang Greffrath   +6 more
wiley   +1 more source

Structural Analyses of the Ankyrin Repeat Domain of TRPV6 and Related TRPV Ion Channels^†,‡

, 2016
Transient receptor potential (TRP) proteins are cation channels composed of a transmembrane domain flanked by large N- and C-terminal cytoplasmic domains.
Rachelle Gaudet (1287813), Polina V. Lishko (1277544), Robert J. Huang (2452591), Christopher B. Phelps (2452597), Ruiqi R. Wang (2452594)   +4 more
core   +1 more source

Role of transient receptor potential (TRP) channels in osteoarthritis: a comprehensive review

Frontiers in Pharmacology
Osteoarthritis (OA) is a chronic degenerative joint disease, primarily characterized by the degeneration of articular cartilage, synovial inflammation, and persistent pain, which severely impairs the quality of life for hundreds of millions of patients ...
Pengyan Qiao, Wei Wang, Sumiao Liu, Yanli Yang, Pingzhi Wang, Yang Liu, Yazhen Su, Peng Hu, Jie Pan, Liyun Zhang   +9 more
doaj   +1 more source

Evaluating FABP5 as a Therapeutic Target for Pain Management

European Journal of Pain, Volume 30, Issue 4, April 2026.
ABSTRACT Background and Objective Fatty acid‐binding proteins (FABPs) are intracellular lipid transporters. Pharmacological inhibition of FABP5 is analgesic in preclinical visceral, inflammatory, neuropathic and joint pain models. Genetic knockout or knockdown of FABP5 induces analgesia in select visceral and inflammatory pain models.
William Warren, Myles Osborn, Martin Kaczocha, Andrew Yates, Saoirse O'Sullivan   +4 more
wiley   +1 more source

TRPV1-target drugs for the treatment of orofacial pain

Frontiers in Pharmacology
Orofacial pain, encompassing sensory and emotional discomfort in the facial and oral regions, is a multifaceted condition that significantly impacts patients’ quality of life.
Ana Cláudia Macedo Andrade, Natalia Molina Esquivel, Florencia Goldschmied Rossel, Bruna Benso   +3 more
doaj   +1 more source