Results 51 to 60 of about 6,526 (131)

Evaluating FABP5 as a Therapeutic Target for Pain Management

European Journal of Pain, Volume 30, Issue 4, April 2026.
ABSTRACT Background and Objective Fatty acid‐binding proteins (FABPs) are intracellular lipid transporters. Pharmacological inhibition of FABP5 is analgesic in preclinical visceral, inflammatory, neuropathic and joint pain models. Genetic knockout or knockdown of FABP5 induces analgesia in select visceral and inflammatory pain models.
William Warren, Myles Osborn, Martin Kaczocha, Andrew Yates, Saoirse O'Sullivan   +4 more
wiley   +1 more source

Pharmacological manipulation of the immediate effects of spinal trauma in neonatal rats reveals a crucial role for TRPV4 receptors

The Journal of Physiology, Volume 604, Issue 7, Page 3077-3093, 1 April 2026.
Abstract figure legend A, schematic illustration of the ventral aspect of an ex vivo preparation of the entire CNS from a neonatal rat subjected to a calibrated thoracic impact. The trauma induced a large depolarising injury potential (DIP, black trace) recorded from the L5 ventral root (VRrL5), which was markedly reduced by transient receptor ...
Atiyeh Mohammadshirazi, Caterina Ciani, Francesca Emma Mongelli, Rashid Giniatullin, Carmen Falcone, Giuliano Taccola   +5 more
wiley   +1 more source

In the gravid human uterus, oxytocin induces smooth muscle cell contraction via transient receptor potential vanilloid 4 channel activation

The Journal of Physiology, Volume 604, Issue 7, Page 3135-3158, 1 April 2026.
Abstract figure legend In gravid human uterus smooth muscle, the oxytocin receptor (OXTR) and transient receptor potential vanilloid 4 (TRPV4) calcium channel colocalize at <40 nm by proximity ligation. TRPV4 is necessary for oxytocin‐induced calcium influx and contractility in uterine smooth muscle cells.
Daiana Fornes, Jessica R. Ansari, Guillermina Michel, Cristina M. Alvira, David N. Cornfield   +4 more
wiley   +1 more source

Intravesical Cannabidiol for Inflammation and Pain in Interstitial Cystitis/Bladder Pain Syndrome via TLR4/NF-κB and TRPV1 Modulation

The World Journal of Men's Health
Purpose: This study explored the anti-inflammatory and analgesic mechanisms of intravesical cannabidiol (CBD) in cyclophosphamide (CYP)-induced interstitial cystitis/bladder pain syndrome (IC/BPS) rats. Materials and Methods: Female Sprague-Dawley rats
Jun Jie Piao, Soomin Kim, Hwa Jong Lee, Guan Qun Zhu, Kyung-Hwa Jeon, Sang-Hyuck Park, Rui-Li Guan, Wen Jie Tian, Zhong Cheng Xin, Sae Woong Kim, Woong Jin Bae   +10 more
doaj   +1 more source

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

FEBS Open Bio, Volume 16, Issue 3, Page 520-531, March 2026.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

Editorial: Vulvodynia and beyond: innate immune sensing, microbes, inflammation, and chronic pain

Frontiers in Cellular and Infection Microbiology, 2023
Megan L. Falsetta, Megan L. Falsetta
doaj   +1 more source

Identification of transient receptor potential channel genes from the swimming crab, Portunus Trituberculatus, and their expression profiles under acute temperature stress

BMC Genomics
Background Temperature is an important environment factor that is critical to the survival and growth of crustaceans. However, the mechanisms by which crustaceans detect changes in temperature are still unclear.
Yichen Qian, Qiaoling Yu, Jun Zhang, Yaoyao Han, Xi Xie, Dongfa Zhu   +5 more
doaj   +1 more source

Toward high-resolution modeling of small molecule–ion channel interactions

Frontiers in Pharmacology
Ion channels are critical drug targets for a range of pathologies, such as epilepsy, pain, itch, autoimmunity, and cardiac arrhythmias. To develop effective and safe therapeutics, it is necessary to design small molecules with high potency and ...
Brandon J. Harris, Brandon J. Harris, Phuong T. Nguyen, Guangfeng Zhou, Guangfeng Zhou, Heike Wulff, Frank DiMaio, Vladimir Yarov-Yarovoy, Vladimir Yarov-Yarovoy, Vladimir Yarov-Yarovoy   +9 more
doaj   +1 more source

Sex-related and temperature-dependent responses of transient receptor potential cation channel subfamily vanilloid (TRPVs) genes in chub mackerel.

Sex-related and temperature-dependent responses of transient receptor potential cation channel subfamily vanilloid (TRPVs) genes in chub mackerel.
identifier:oai:t2r2.star.titech.ac.jp ...
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Characterization of temperature-sensitive Transient Receptor Potential Cation Channel Subfamily Vanilloid (TRPV) 1 and its modulation of fshb expression in chub mackerel (Scomber japonicus)

Characterization of temperature-sensitive Transient Receptor Potential Cation Channel Subfamily Vanilloid (TRPV) 1 and its modulation of fshb expression in chub mackerel (Scomber japonicus)
identifier:oai:t2r2.star.titech.ac.jp ...
openaire