Results 51 to 60 of about 1,008,370 (159)

High-threshold mechanosensitive ion channels blocked by a novel conopeptide mediate pressure-evoked pain [PDF]

, 2007
Little is known about the molecular basis of somatosensory mechanotransduction in mammals. We screened a library of peptide toxins for effects on mechanically activated currents in cultured dorsal root ganglion neurons.
Abrahamsen, B, Robinson, M, Rugiero, F, Colless, B, Drew, LJ, Brust, A, Heinzmann, S, Lewis, RJ, Wood, JN, Gale, JE, Cesare, P, Bowden, S   +11 more
core  

The role of the membrane-initiated Heat Shock Response in cancer

Frontiers in Molecular Biosciences, 2016
The heat shock response (HSR) is a cellular response to diverse environmental and physiological stressors resulting in the induction of genes encoding molecular chaperones, proteases and other proteins that are essential for protection and recovery from ...
Zohar eBromberg, Yoram eWeiss
doaj   +1 more source

Transient receptor potential vanilloid 1 and 4 double knockout leads to increased bone mass in mice

Bone Reports, 2020
Calcium balance is important in bone homeostasis. The transient receptor potential vanilloid (TRPV) channel is a nonselective cation channel permeable to calcium and is activated by various physiological and pharmacological stimuli.
Haruki Nishimura, Makoto Kawasaki, Manabu Tsukamoto, Kunitaka Menuki, Hitoshi Suzuki, Takanori Matsuura, Kazuhiko Baba, Yasuhito Motojima, Teruaki Fujitani, Hideo Ohnishi, Yoshiaki Yamanaka, Kenji Kosugi, Yasuaki Okada, Kotaro Tokuda, Takafumi Tajima, Toru Yoshioka, Nobukazu Okimoto, Yoichi Ueta, Akinori Sakai   +18 more
doaj   +1 more source

Low‐threshold cutaneous mechanoreceptors on the foot sole have enhanced sensitivity when skin temperature is elevated

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic illustration of microneurography recordings used to examine the effects of local skin heating on cutaneous mechanoreceptor responses in the human foot (left panel). A microelectrode inserted into a peripheral nerve records single‐unit activity from tactile afferent fibres while controlled mechanical stimuli are applied ...
Erika E. Howe, Michael Apollinaro, Joanna Reeves, Christopher Nester, Leah R. Bent   +4 more
wiley   +1 more source

Activation of native TRPC1/C5/C6 channels by endothelin-1 is mediated by both PIP3 and PIP2 in rabbit coronary artery myocytes [PDF]

, 2009
We investigate activation mechanisms of native TRPC1/C5/C6 channels (termed TRPC1 channels) by stimulation of endothelin-1 (ET-1) receptor subtypes in freshly dispersed rabbit coronary artery myocytes using single channel recording and ...
Anthony P. Albert, Saleh, Sohag N., Albert, Anthony P., Sohag N. Saleh, William A. Large, Large, William A., Large, WA, Saleh, SN, Albert, AP   +8 more
core   +1 more source

The Role of Neuropeptide Y in Dental Pulp: Balancing Neurogenic Inflammation and Pain Modulation

International Endodontic Journal, Volume 59, Issue 10, Page 2028-2045, October 2026.
ABSTRACT Background Dental pulp is a densely innervated, low‐compliance tissue in which neurogenic inflammation can rapidly escalate into oedema, raised intrapulpal pressure, microvascular compromise, and pain. While Substance P (SP) and Calcitonin gene‐related peptide (CGRP) are well‐established drivers of pulp vasodilation, the Neuroopeptide Y (NPY ...
Javier Caviedes‐Bucheli, Esteban Ulate, Hugo‐Roberto Munoz, Nestor Ríos‐Osorio   +3 more
wiley   +1 more source

Functions of TRPs in retinal tissue in physiological and pathological conditions

Frontiers in Molecular Neuroscience
The Transient Receptor Potential (TRP) constitutes a family of channels subdivided into seven subfamilies: Ankyrin (TRPA), Canonical (TRPC), Melastatin (TRPM), Mucolipin (TRPML), no-mechano-potential C (TRPN), Polycystic (TRPP), and Vanilloid (TRPV ...
Thaianne Hanah Oliveira do Nascimento, Danniel Pereira-Figueiredo, Louise Veroneze, Amanda Alves Nascimento, Francesco De Logu, Romina Nassini, Paula Campello-Costa, Adriana da Cunha Faria-Melibeu, Daniel Souza Monteiro de Araújo, Karin Costa Calaza, Karin Costa Calaza   +10 more
doaj   +1 more source

Tris-hydroxymethyl-aminomethane enhances capsaicin-induced intracellular Ca2+ influx through transient receptor potential V1 (TRPV1) channels

Journal of Pharmacological Sciences, 2016
Non-selective transient receptor potential vanilloid (TRPV) cation channels are activated by various insults, including exposure to heat, acidity, and the compound capsaicin, resulting in sensations of pain in the skin, visceral organs, and oral cavity ...
Satoshi Murakami, Yuka Sudo, Kanako Miyano, Hitomi Nishimura, Motohiro Matoba, Seiji Shiraishi, Hiroki Konno, Yasuhito Uezono   +7 more
doaj   +1 more source

Pharmacology of vanilloid transient receptor potential cation channels [PDF]

, 2009
Depending on their primary structure, the 28 mammalian transient receptor potential (TRP) cation channels identified so far can be sorted into 6 subfamilies: TRPC ("Canonical"), TRPV ("Vanilloid"), TRPM ("Melastatin"), TRPP ("Polycystin"), TRPML ...
Appendino, Giovanni, Nilius, Bernd, Vriens, Joris   +2 more
core   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, Volume 16, Issue 8, Page 1477-1490, August 2026.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source