Results 51 to 60 of about 9,155 (170)

Functions of TRPs in retinal tissue in physiological and pathological conditions

Frontiers in Molecular Neuroscience
The Transient Receptor Potential (TRP) constitutes a family of channels subdivided into seven subfamilies: Ankyrin (TRPA), Canonical (TRPC), Melastatin (TRPM), Mucolipin (TRPML), no-mechano-potential C (TRPN), Polycystic (TRPP), and Vanilloid (TRPV ...
Thaianne Hanah Oliveira do Nascimento, Danniel Pereira-Figueiredo, Louise Veroneze, Amanda Alves Nascimento, Francesco De Logu, Romina Nassini, Paula Campello-Costa, Adriana da Cunha Faria-Melibeu, Daniel Souza Monteiro de Araújo, Karin Costa Calaza, Karin Costa Calaza   +10 more
doaj   +1 more source

Tris-hydroxymethyl-aminomethane enhances capsaicin-induced intracellular Ca2+ influx through transient receptor potential V1 (TRPV1) channels

Journal of Pharmacological Sciences, 2016
Non-selective transient receptor potential vanilloid (TRPV) cation channels are activated by various insults, including exposure to heat, acidity, and the compound capsaicin, resulting in sensations of pain in the skin, visceral organs, and oral cavity ...
Satoshi Murakami, Yuka Sudo, Kanako Miyano, Hitomi Nishimura, Motohiro Matoba, Seiji Shiraishi, Hiroki Konno, Yasuhito Uezono   +7 more
doaj   +1 more source

Phagocytosis depends on TRPV2-mediated calcium influx and requires TRPV2 in lipids rafts: alteration in macrophages from patients with cystic fibrosis. [PDF]

, 2018
Whereas many phagocytosis steps involve ionic fluxes, the underlying ion channels remain poorly defined. As reported in mice, the calcium conducting TRPV2 channel impacts the phagocytic process.
A Abu-Arish, A Aderem, A Di, A Magenau, A Oláh, A Perez, A Perálvarez-Marín, B Svobodova, D Wang, DJ Hackam, E Hisanaga, E Pernet, F Antigny, F Antigny, G Santoni, H Balghi, H Grassmé, H Matsui, JD Young, JH Guo, Jvan Grevenynghe, K Abe, K Aoyagi, K Simonin-Le Jeune, K-Y Jih, L Ambrus, L Nie, L Petrocellis De, L Wei, LM Carrithers, LV Deriy, M Lévêque, M Nabissi, M Nagasawa, M Nagasawa, M Saito, MD Carrithers, MJ Caterina, MP Kowalski, N Qin, NE Alexis, P Schatzlmaier, P Zhang, T Hishikawa, T Ma, TM Link, Y Iwata, É Sághy   +47 more
core   +4 more sources

Modulation of the endocannabinoid system reduces inflammatory signalling in canine mammary carcinoma cells

Veterinary Record Open, Volume 13, Issue 1, June 2026.
Abstract Background Canine mammary carcinoma (CMC) is characterised by a chronic inflammatory microenvironment resembling human breast cancer; however, the upstream regulatory mechanisms driving this phenotype remain unclear. The endocannabinoid system (ECS) has emerged as a potential modulator of inflammation and tumour biology.
Gianluca Antonio Franco, Ylenia Marino, Claudia Rifici, Roberta Fusco, Davide di Paola, Salvatore Cuzzocrea, Giuseppe Catone, Cecilia Vullo, Enrico Gugliandolo   +8 more
wiley   +1 more source

“Immuno-Transient Receptor Potential Ion Channels”: The Role in Monocyte- and Macrophage-Mediated Inflammatory Responses

Frontiers in Immunology, 2018
Monocytes and macrophages play important roles in health and disease. They have a central role in protecting the host, as they clear pathogens and modulate other immune cell functions through the production of regulatory molecules.
Giorgio Santoni, Maria Beatrice Morelli, Maria Beatrice Morelli, Consuelo Amantini, Matteo Santoni, Massimo Nabissi, Oliviero Marinelli, Oliviero Marinelli, Angela Santoni, Angela Santoni   +9 more
doaj   +1 more source

Cells and ionic conductances contributing to spontaneous activity in bladder and urethral smooth muscle

The Journal of Physiology, Volume 604, Issue 9, Page 3611-3632, 1 May 2026.
Abstract figure legend Cells and conductances contributing to spontaneous activity in the lower urinary tract. Bladder and urethra exhibit spontaneous contractions at both cellular and tissue levels. Both detrusor and urethral smooth muscle cells display activity that is regular and rhythmic.
Bernard T. Drumm, Neha Gupta, Alexandru Mircea, Caoimhin S. Griffin   +3 more
wiley   +1 more source

Understand spiciness: mechanism of TRPV1 channel activation by capsaicin. [PDF]

, 2017
Capsaicin in chili peppers bestows the sensation of spiciness. Since the discovery of its receptor, transient receptor potential vanilloid 1 (TRPV1) ion channel, how capsaicin activates this channel has been under extensive investigation using a variety ...
Yang, Fan, Zheng, Jie
core   +2 more sources

Inhibition of Microglial TRPV1 Ameliorates Brain Injury After Intracerebral Hemorrhage by Suppressing AMPK/PINK1‐Mediated Mitophagy

CNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.
After intracerebral hemorrhage, microglial TRPV1 channel opening increases intracellular calcium, triggering excessive AMPK‐PINK1‐mediated mitophagy. This causes microglial dysfunction, neuronal necrosis/apoptosis, blood–brain barrier disruption, and neurological impairment.
Kezhu Chen, Xiangyang Deng, Jun Zeng, Baoye Sun, Jingyu Yu, Tianwen Li, Junjie Zhong, Pengjie Hong, Peng Wang, Fengshi Li, Quan Zhang, Junwei Ren, Qisheng Tang, Tongming Zhu, Jianhong Zhu   +14 more
wiley   +1 more source

Identification of Inhibitory Ca2+ Binding Sites in the Upper Vestibule of the Yeast Vacuolar TRP Channel

iScience, 2019
Summary: By vacuolar patch-clamp and Ca2+ imaging experiments, we show that the yeast vacuolar transient receptor potential (TRPY) channel 1 is activated by cytosolic Ca2+ and inhibited by Ca2+ from the vacuolar lumen.
Mahnaz Amini, Hongmei Wang, Anouar Belkacemi, Martin Jung, Adam Bertl, Gabriel Schlenstedt, Veit Flockerzi, Andreas Beck   +7 more
doaj   +1 more source

The Thoracic Lymphatic Vasculature: Interorgan Strategies to Achieve an Optimal Tissue Function

Comprehensive Physiology, Volume 16, Issue 2, April 2026.
In the thorax, organ‐specific features such as stomata and submesothelial lacunae, pulmonary perivascular and peribronchial vessels, and subepicardial lymphatic network allow the thoracic lymphatics to perform as a dynamically regulated system able to exploit local mechanical forces and tissue‐specific architecture to maintain fluid and solute ...
Daniela Negrini, Eleonora Solari, Cristiana Marcozzi, Andrea Moriondo   +3 more
wiley   +1 more source