Results 61 to 70 of about 9,155 (170)

Influence of 1α, 25-dihydroxyvitamin D3 [1, 25(OH)2D3] on the expression of Sox 9 and the transient receptor potential vanilloid 5/6 ion channels in equine articular chondrocytes [PDF]

, 2014
Background Sox 9 is a major marker of chondrocyte differentiation. When chondrocytes are cultured in vitro they progressively de-differentiate and this is associated with a decline in Sox 9 expression. The active form of vitamin D, 1, 25 (OH)2D3 has
B Lehmann, B Nilius, BD Boyan, CJ Brew, D Kumar, DK Bonen, E Wright, EC Castillo, G Hargus, GS Lee, H Akiyama, HM Embark, I Kou, I Sekiya, IM Hdud, IM Hdud, IM Hdud, J Teerapornpuntakit, JC Fleet, JG Hoenderop, JG Hoenderop, JI Sive, K Gavenis, LC Bridgewater, LC Tetlow, LP Zanello, M Cucchiarini, M Fernandez-Cancio, M Zhang, MR Haussler, N Shintani, PD Benya, PM Gebhard, Q Zhao, R Bouillon, R Vennekens, RJ Wood, S Morais Da Silva, S Taparia, SJ Van Cromphaut, SR Tew, SR Tew, T Aigner, T Kirsch, T Nijenhuis, T Wagner, V Lefebvre, W Bi, W Bi, WF Xie, Y Kawakami, Y Koyano, Y Song, Y Xue   +53 more
core   +2 more sources

Bidirectional Roles of TRPV1 in a Latent Sensitization Model of Myofascial Low Back Pain

European Journal of Pain, Volume 30, Issue 4, April 2026.
ABSTRACT Introduction Chronic primary low back pain (cpLBP) is a global health concern with poorly understood pathomechanisms, potentially involving spinal sensitization. The capsaicin receptor TRPV1 plays a crucial role in sensitization across pain models.
Vivian Blechschmidt, Bastian Schlickenrieder, Jonathan R. Husk, Ulrich Hoheisel, Handan Mörz, Rolf‐Detlef Treede, Wolfgang Greffrath   +6 more
wiley   +1 more source

The role of TRP proteins in mast cells

Frontiers in Immunology, 2012
TRP proteins form cation channels that are regulated through strikingly diverse mechanisms including multiple cell surface receptors, changes in temperature, in pH and osmolarity, in cytosolic Ca2+ concentration ([Ca2+]i) and by phosphoinositides. The 28
Marc eFreichel, Julia eAlmering, Volodymyr eTsvilovskyy   +2 more
doaj   +1 more source

Regional differences in store-operated Ca2+ entry in the epithelium of the intact human lens [PDF]

, 2009
An elevated level of Ca2+ is an important factor in cataract, yet precisely how Ca2+ enters the lens is unknown. Lens epithelial cells contain a range of G-protein–coupled receptors and receptor tyrosine kinases that induce increases in intracellular Ca2+
Duncan, George, Illingworth, Christopher D., Rhodes, Jeremy D., Russell, Sarah L., Wormstone, I. Michael   +4 more
core   +1 more source

Evaluating FABP5 as a Therapeutic Target for Pain Management

European Journal of Pain, Volume 30, Issue 4, April 2026.
ABSTRACT Background and Objective Fatty acid‐binding proteins (FABPs) are intracellular lipid transporters. Pharmacological inhibition of FABP5 is analgesic in preclinical visceral, inflammatory, neuropathic and joint pain models. Genetic knockout or knockdown of FABP5 induces analgesia in select visceral and inflammatory pain models.
William Warren, Myles Osborn, Martin Kaczocha, Andrew Yates, Saoirse O'Sullivan   +4 more
wiley   +1 more source

Transient Receptor Potential Vanilloid 1 Expression Mediates Capsaicin-Induced Cell Death

Frontiers in Physiology, 2018
The transient receptor potential (TRP) ion channel family consists of a broad variety of non-selective cation channels that integrate environmental physicochemical signals for dynamic homeostatic control.
Ricardo Ramírez-Barrantes, Claudio Córdova, Sebastian Gatica, Sebastian Gatica, Belén Rodriguez, Carlo Lozano, Ivanny Marchant, Cesar Echeverria, Felipe Simon, Felipe Simon, Pablo Olivero   +10 more
doaj   +1 more source

Stimulation of 3D osteogenesis by mesenchymal stem cells using a nanovibrational bioreactor [PDF]

, 2017
Bone grafts are one of the most commonly transplanted tissues. However, autologous grafts are in short supply, and can be associated with pain and donor-site morbidity.
Biggs, Manus J. P., Blackburn, Gavin, Burgess, Karl, Childs, Peter G., Curtis, Adam S. G., Dalby, Matthew J., González-García, Cristina, Jayawarna, Vineetha, Orapiriyakul, Wich, Pemberton, Gabriel D., Reid, Stuart, Salmerón-Sánchez, Manuel, Thomas, Dilip, Tsimbouri, Penelope M., Vallejo-Giraldo, Catalina, Yang, Jingli   +15 more
core   +2 more sources

Pharmacological manipulation of the immediate effects of spinal trauma in neonatal rats reveals a crucial role for TRPV4 receptors

The Journal of Physiology, Volume 604, Issue 7, Page 3077-3093, 1 April 2026.
Abstract figure legend A, schematic illustration of the ventral aspect of an ex vivo preparation of the entire CNS from a neonatal rat subjected to a calibrated thoracic impact. The trauma induced a large depolarising injury potential (DIP, black trace) recorded from the L5 ventral root (VRrL5), which was markedly reduced by transient receptor ...
Atiyeh Mohammadshirazi, Caterina Ciani, Francesca Emma Mongelli, Rashid Giniatullin, Carmen Falcone, Giuliano Taccola   +5 more
wiley   +1 more source

In the gravid human uterus, oxytocin induces smooth muscle cell contraction via transient receptor potential vanilloid 4 channel activation

The Journal of Physiology, Volume 604, Issue 7, Page 3135-3158, 1 April 2026.
Abstract figure legend In gravid human uterus smooth muscle, the oxytocin receptor (OXTR) and transient receptor potential vanilloid 4 (TRPV4) calcium channel colocalize at <40 nm by proximity ligation. TRPV4 is necessary for oxytocin‐induced calcium influx and contractility in uterine smooth muscle cells.
Daiana Fornes, Jessica R. Ansari, Guillermina Michel, Cristina M. Alvira, David N. Cornfield   +4 more
wiley   +1 more source

TRPV1-target drugs for the treatment of orofacial pain

Frontiers in Pharmacology
Orofacial pain, encompassing sensory and emotional discomfort in the facial and oral regions, is a multifaceted condition that significantly impacts patients’ quality of life.
Ana Cláudia Macedo Andrade, Natalia Molina Esquivel, Florencia Goldschmied Rossel, Bruna Benso   +3 more
doaj   +1 more source