Involvement of TRPV3 and TRPM8 ion channel proteins in induction of mammalian cold-inducible proteins [PDF]
, 2018 Cold-inducible RNA-binding protein (CIRP), RNA-binding motif protein 3 (RBM3) and serine and arginine rich splicing factor 5 (SRSF5) are RNA-binding proteins that are transcriptionally upregulated in response to moderately low temperatures and a variety ...
Fujita Jun +7 more
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Emerging Roles of L-Type Voltage-Gated and Other Calcium Channels in T Lymphocytes [PDF]
, 2013 In T lymphocytes, calcium ion controls a variety of biological processes including development, survival, proliferation, and effector functions. These distinct and specific roles are regulated by different calcium signals, which are generated by various ...
Abdallah eBadou +4 more
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Editorial: Vulvodynia and beyond: innate immune sensing, microbes, inflammation, and chronic pain
Frontiers in Cellular and Infection Microbiology, 2023 Megan L. Falsetta, Megan L. Falsetta
doaj +1 more source
Transient receptor potential channels in Flaviviridae infection: A comprehensive review
ChannelsDiseases caused by Flaviviridae viruses exert profound global health and economic burdens due to their high incidence and associated mortality. Infection by the Flaviviridae family often leads to severe acute or chronic illnesses, including hemorrhagic ...
Fuchun Jiang +2 more
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Effect of osmotic stress on the expression of TRPV4 and BKCa channels and possible interaction with ERK1/2 and p38 in cultured equine chondrocytes [PDF]
, 2014 The metabolic activity of articular chondrocytes is influenced by osmotic alterations that occur in articular cartilage secondary to mechanical load.
Ali Mobasheri +7 more
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Microglia in Alzheimer's disease: a role for ion channels [PDF]
, 2018 Alzheimer's disease is the most common form of dementia, it is estimated to affect over 40 million people worldwide. Classically, the disease has been characterized by the neuropathological hallmarks of aggregated extracellular amyloid-β and ...
Dallas, Mark L. +4 more
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BMC GenomicsBackground Temperature is an important environment factor that is critical to the survival and growth of crustaceans. However, the mechanisms by which crustaceans detect changes in temperature are still unclear.
Yichen Qian +5 more
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Toward high-resolution modeling of small molecule–ion channel interactions
Frontiers in PharmacologyIon channels are critical drug targets for a range of pathologies, such as epilepsy, pain, itch, autoimmunity, and cardiac arrhythmias. To develop effective and safe therapeutics, it is necessary to design small molecules with high potency and ...
Brandon J. Harris +9 more
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Ionic basis of a mechanotransduction current in adult rat dorsal root ganglion neurons [PDF]
, 2006 Sensory mechanical transduction – necessary for hearing, proprioception, and the senses of touch and pain – remains poorly understood. In somatosensation, even the basic properties of the mechanically sensitive excitatory ionic currents that are assumed ...
Gordon C McCarter, Jon D Levine
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Endocannabinoid system and anticancer properties of cannabinoids [PDF]
, 2016 Cannabinoids impact human body by binding to cannabinoids receptors (CB1 and CB2). The two main phytocannabinoids are Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD).
Nowak, Agnieszka +3 more
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