Results 81 to 90 of about 238 (118)
Toward high-resolution modeling of small molecule–ion channel interactions
Frontiers in PharmacologyIon channels are critical drug targets for a range of pathologies, such as epilepsy, pain, itch, autoimmunity, and cardiac arrhythmias. To develop effective and safe therapeutics, it is necessary to design small molecules with high potency and ...
Brandon J. Harris +9 more
doaj +1 more source
, 2012 Transient receptor potential vanilloid (TRPV) channels respond to polymodal stresses to induce pain, inflammation and tissue fibrosis. In this study, we probed for their functional expression in human conjunctival epithelial (HCjE) cells and ex vivo ...
Mergler, S. +7 more
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, 2018 Since their discovery in late 1970, transient receptor potential (TRP) channels have been implicated in a variety of cellular and physiological functions (Minke, 2010). The superfamily of TRP channels consists of nearly 30 members that are organized into
Lishko, Polina V, Bjorkgren, Ida
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Determining the functional role of TRPC channels in primary cells.
, 2005 Although the TRPC members of the mammalian transient receptor potential TRP cation channel family were the first to be described in 1995, the depth of knowledge of TRPC channels has fallen behind that of their counterparts in the TRPV and TRPM ...
Su Li (294188) +5 more
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, 2019 Transient receptor potential (TRP) channels belong to a superfamily of sensory-related ion channels responding to a wide variety of thermal, mechanical, or chemical stimuli.
최선
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Contribution of TRPV channels to osmosensory transduction, thirst, and vasopressin release
, 2008 Systemic osmoregulation is an integrated physiological process through which water intake and excretion are continuously balanced against salt intake and excretion to maintain the osmolality of the extracellular fluid near an optimal ‘set-point’ value ...
Sharif-Naeini, R. +3 more
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TRPV4: MOLECULAR CONDUCTOR OF A DIVERSE ORCHESTRA
, 2016 Transient receptor potential vanilloid type 4 (TRPV4) ion channels are Ca2+ permeable non-selective cation channels which exhibit a remarkable range of expression throughout the human body.
White, John, P.M +5 more
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TRP channels in kidney disease.
, 2007 Contains fulltext : 52278.pdf (Publisher’s version ) (Open Access)Mammalian TRP channel proteins form six-transmembrane cation-permeable channels that may be grouped into six subfamilies on the basis of amino acid sequence homology ...
Bindels, R.J.M. +5 more
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, 2012 Hypoxia-induced pulmonary vasoconstriction (HPV) is critical for matching of ventilation/perfusion in lungs. Although hypoxic inhibition of K+ channels has been a leading hypothesis for depolarization of pulmonary arterial smooth muscle cells (PASMCs ...
Eun-Young Seo +9 more
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TRP channels in normal and dystrophic skeletal muscle.
, 2012 TRP proteins constitute non-selective cation-permeable ion channels, most of which are permeable to Ca(2+). In skeletal muscle, several isoforms of the TRPC (Canonical), TRPV (Vanilloid) and TRPM (Melastatin) subfamilies are expressed.
Gailly, Philippe
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