Results 91 to 100 of about 1,008,370 (159)

Toward high-resolution modeling of small molecule–ion channel interactions

Frontiers in Pharmacology
Ion channels are critical drug targets for a range of pathologies, such as epilepsy, pain, itch, autoimmunity, and cardiac arrhythmias. To develop effective and safe therapeutics, it is necessary to design small molecules with high potency and ...
Brandon J. Harris, Brandon J. Harris, Phuong T. Nguyen, Guangfeng Zhou, Guangfeng Zhou, Heike Wulff, Frank DiMaio, Vladimir Yarov-Yarovoy, Vladimir Yarov-Yarovoy, Vladimir Yarov-Yarovoy   +9 more
doaj   +1 more source

Transient receptor potential cation channels in disease [PDF]

, 2007
The transient receptor potential (TRP) superfamily consists of a large number of cation channels that are mostly permeable to both monovalent and divalent cations.
Owsianik, Grzegorz, Voets, Thomas, Nilius, Bernd, Peters, John A.   +3 more
core   +1 more source

Regulation Mechanisms of TRPV Channels by Protein Kinase C [PDF]

, 2007
総合研究大学院大学博士（理学）TRP (transient receptor potential) channels were first described in Drosophila, where photoreceptors carrying trp gene mutations exhibited an abnormal transient responsiveness to continuous light.
東, 智広, HIGASHI, Tomohiro, ヒガシ, トモヒロ   +2 more
core  

Worm sensation! [PDF]

, 2005
Wood John N, Drew, LJ, Liam J Drew, John N Wood, Wood, JN, Drew Liam J   +5 more
core   +1 more source

On the putative role of transient receptor potential cation channels in asthma

, 2009
The mammalian transient receptor potential (TRP) superfamily consists of 28 mammalian TRP cation channels, which can be subdivided into six main subfamilies: the TRPC ('Canonical'), TRPV ('Vanilloid'), TRPM ('Melastatin'), TRPP ('Polycystin'), TRPML ...
Vennekens, Rudi, R. Vennekens, Colsoul, Barbara, Nilius, Bernd, B. Colsoul, B. Nilius   +5 more
core   +1 more source

Sex-related and temperature-dependent responses of transient receptor potential cation channel subfamily vanilloid (TRPVs) genes in chub mackerel.

Sex-related and temperature-dependent responses of transient receptor potential cation channel subfamily vanilloid (TRPVs) genes in chub mackerel.
identifier:oai:t2r2.star.titech.ac.jp ...
openaire   +1 more source

TRPV channels mediate temperature-sensing in human corneal endothelial cells

, 2010
The physiology and transparency of the cornea are dependent on corneal endothelial function. the role of temperature sensitive ion channels in maintaining such activity is unknown.
Mergler, Stefan, Valtink, Monika, Lindemann, Dirk, Reinach, Peter S., Pleyer, Uwe, Engelmann, Katrin, Coulson-Thomas, Vivien Jane [UNIFESP]   +6 more
core   +1 more source

Multimodal Activation and Regulation of Neuronal Mechanosensitive Cation Channels

, 2008
Recent findings show that mechanosensitive cation channels are expressed in the central nervous system. These molecules can be found not only, as expected, in mechanosensory cells but also in neurons not involved in sensory mechanotransduction.
PELLEGRINI M., PELLEGRINO M, BARSANTI C, PELLEGRINO, MARIO, PELLEGRINI, Monica   +4 more
core  

Characterization of temperature-sensitive Transient Receptor Potential Cation Channel Subfamily Vanilloid (TRPV) 1 and its modulation of fshb expression in chub mackerel (Scomber japonicus)

Characterization of temperature-sensitive Transient Receptor Potential Cation Channel Subfamily Vanilloid (TRPV) 1 and its modulation of fshb expression in chub mackerel (Scomber japonicus)
identifier:oai:t2r2.star.titech.ac.jp ...
openaire   +1 more source

From the TPR pathway and the neuroimmune unit to the cutaneous HPA axis: a neuro-endo-immune cross-talk in rosacea. [PDF]

Front Med (Lausanne)
He Z, Feng YY, Ning T, Wu P, Yang C, Zhang Q.   +5 more
europepmc   +1 more source