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Human mutations highlight an intersubunit cation–π bond that stabilizes the closed but not open or inactivated states of TRPV channels [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance Transient receptor potential (TRP) channels are key cation channels that respond to thermal, chemical, electric, or mechanical stimuli. There are >60 mutations known in TrpV4 that cause defects in bone or neural development.
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Hearing Research, 2005
The transient receptor potential cation channel subfamily V (TRPV) is a non-specific cation ion channel receptor family that is gated by heat, protons, low extracellular osmolarity and arachidonic acid derivatives. Since some of these endogenous agonists of TRPV receptors are reactive oxygen intermediates produced by lipoxygenases, it has been ...
Tadashi Kitahara +2 more
exaly +3 more sources
The transient receptor potential cation channel subfamily V (TRPV) is a non-specific cation ion channel receptor family that is gated by heat, protons, low extracellular osmolarity and arachidonic acid derivatives. Since some of these endogenous agonists of TRPV receptors are reactive oxygen intermediates produced by lipoxygenases, it has been ...
Tadashi Kitahara +2 more
exaly +3 more sources
The FASEB Journal, 2017
Study objective Mechanical ventilation can damage the lung by causing endothelial barrier failure, edema formation and lung injury. Yet, the exact mechanisms underlying the mechanotransduction at the microvascular barrier are still unclear.
Laura Michalick +2 more
openaire +1 more source
Study objective Mechanical ventilation can damage the lung by causing endothelial barrier failure, edema formation and lung injury. Yet, the exact mechanisms underlying the mechanotransduction at the microvascular barrier are still unclear.
Laura Michalick +2 more
openaire +1 more source
Membrane échangeur de cation inorganique à BBB : focus sur le transport du lithium et les canaux TRPV dans les cellules endothéliales cérébrales humaines Dans un premier temps, nous avons exploré l'effet du lithium sur l'expression des ARNs des transporteurs et des enzymes de métabolisation dans les cellules hCMEC / D3.
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A cooperative knock-on mechanism underpins Ca2+-selective cation permeation in TRPV channels
Journal of General Physiology, 2023Callum M Ives, Ulrich Zachariae
exaly
Blockade of TRPV channels by intracellular spermine
Journal of General Physiology, 2023Grigory Maksaev +2 more
exaly
Calcium binding and permeation in TRPV channels: Insights from molecular dynamics simulations
Journal of General Physiology, 2023Chen Song, Chunhong Liu, Lingfeng Xue
exaly
Structural insights into the gating mechanisms of TRPV channels
Cell Calcium, 2020Vera Moiseenkova-Bell +2 more
exaly
Role of the TRPV Channels in the Endoplasmic Reticulum Calcium Homeostasis
Cells, 2020V'Yacheslav Lehen'Kyi +2 more
exaly
New Potential Therapies from Vanilloid Transient Receptor Cation (TRPV) Channels.
Current pharmaceutical design, 2008Di Marzo V, Starowicz K
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