Results 41 to 50 of about 6,526 (131)

Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases

BMEMat, Volume 4, Issue 2, June 2026.
This review highlights the immunomodulatory potential of nanomaterials (NMs) in treating neurodegenerative diseases (NDs). It focuses on their roles in regulating innate and adaptive immune responses to maintain immune homeostasis. By providing insights into these mechanisms, the review lays the groundwork for innovative NMs therapeutic strategies to ...
Xinru Zhou, Jia Liu, Shulin Lai, Suhan Yin, Bingmin Luo, Longquan Shao, Yiyuan Kang   +6 more
wiley   +1 more source

Modulation of the endocannabinoid system reduces inflammatory signalling in canine mammary carcinoma cells

Veterinary Record Open, Volume 13, Issue 1, June 2026.
Abstract Background Canine mammary carcinoma (CMC) is characterised by a chronic inflammatory microenvironment resembling human breast cancer; however, the upstream regulatory mechanisms driving this phenotype remain unclear. The endocannabinoid system (ECS) has emerged as a potential modulator of inflammation and tumour biology.
Gianluca Antonio Franco, Ylenia Marino, Claudia Rifici, Roberta Fusco, Davide di Paola, Salvatore Cuzzocrea, Giuseppe Catone, Cecilia Vullo, Enrico Gugliandolo   +8 more
wiley   +1 more source

The role of TRP proteins in mast cells

Frontiers in Immunology, 2012
TRP proteins form cation channels that are regulated through strikingly diverse mechanisms including multiple cell surface receptors, changes in temperature, in pH and osmolarity, in cytosolic Ca2+ concentration ([Ca2+]i) and by phosphoinositides. The 28
Marc eFreichel, Julia eAlmering, Volodymyr eTsvilovskyy   +2 more
doaj   +1 more source

Cells and ionic conductances contributing to spontaneous activity in bladder and urethral smooth muscle

The Journal of Physiology, Volume 604, Issue 9, Page 3611-3632, 1 May 2026.
Abstract figure legend Cells and conductances contributing to spontaneous activity in the lower urinary tract. Bladder and urethra exhibit spontaneous contractions at both cellular and tissue levels. Both detrusor and urethral smooth muscle cells display activity that is regular and rhythmic.
Bernard T. Drumm, Neha Gupta, Alexandru Mircea, Caoimhin S. Griffin   +3 more
wiley   +1 more source

Transient Receptor Potential Vanilloid 1 Expression Mediates Capsaicin-Induced Cell Death

Frontiers in Physiology, 2018
The transient receptor potential (TRP) ion channel family consists of a broad variety of non-selective cation channels that integrate environmental physicochemical signals for dynamic homeostatic control.
Ricardo Ramírez-Barrantes, Claudio Córdova, Sebastian Gatica, Sebastian Gatica, Belén Rodriguez, Carlo Lozano, Ivanny Marchant, Cesar Echeverria, Felipe Simon, Felipe Simon, Pablo Olivero   +10 more
doaj   +1 more source

Inhibition of Microglial TRPV1 Ameliorates Brain Injury After Intracerebral Hemorrhage by Suppressing AMPK/PINK1‐Mediated Mitophagy

CNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.
After intracerebral hemorrhage, microglial TRPV1 channel opening increases intracellular calcium, triggering excessive AMPK‐PINK1‐mediated mitophagy. This causes microglial dysfunction, neuronal necrosis/apoptosis, blood–brain barrier disruption, and neurological impairment.
Kezhu Chen, Xiangyang Deng, Jun Zeng, Baoye Sun, Jingyu Yu, Tianwen Li, Junjie Zhong, Pengjie Hong, Peng Wang, Fengshi Li, Quan Zhang, Junwei Ren, Qisheng Tang, Tongming Zhu, Jianhong Zhu   +14 more
wiley   +1 more source

The Thoracic Lymphatic Vasculature: Interorgan Strategies to Achieve an Optimal Tissue Function

Comprehensive Physiology, Volume 16, Issue 2, April 2026.
In the thorax, organ‐specific features such as stomata and submesothelial lacunae, pulmonary perivascular and peribronchial vessels, and subepicardial lymphatic network allow the thoracic lymphatics to perform as a dynamically regulated system able to exploit local mechanical forces and tissue‐specific architecture to maintain fluid and solute ...
Daniela Negrini, Eleonora Solari, Cristiana Marcozzi, Andrea Moriondo   +3 more
wiley   +1 more source

TRPV1-target drugs for the treatment of orofacial pain

Frontiers in Pharmacology
Orofacial pain, encompassing sensory and emotional discomfort in the facial and oral regions, is a multifaceted condition that significantly impacts patients’ quality of life.
Ana Cláudia Macedo Andrade, Natalia Molina Esquivel, Florencia Goldschmied Rossel, Bruna Benso   +3 more
doaj   +1 more source

Bidirectional Roles of TRPV1 in a Latent Sensitization Model of Myofascial Low Back Pain

European Journal of Pain, Volume 30, Issue 4, April 2026.
ABSTRACT Introduction Chronic primary low back pain (cpLBP) is a global health concern with poorly understood pathomechanisms, potentially involving spinal sensitization. The capsaicin receptor TRPV1 plays a crucial role in sensitization across pain models.
Vivian Blechschmidt, Bastian Schlickenrieder, Jonathan R. Husk, Ulrich Hoheisel, Handan Mörz, Rolf‐Detlef Treede, Wolfgang Greffrath   +6 more
wiley   +1 more source

Modulation of transient receptor potential vanilloid 4-mediated membrane currents and synaptic transmission by protein kinase C

Molecular Pain, 2009
Background Transient receptor potential Vanilloid (TRPV) receptors are involved in nociception and are expressed predominantly in sensory neurons. TRPV1, a non-selective cation channel has been extensively studied and is responsible for inflammatory ...
Premkumar Louis S, Yu Shuang-Quan, Cao De-Shou   +2 more
doaj   +1 more source