Results 11 to 20 of about 1,008,370 (159)

Molecular details of ruthenium red pore block in TRPV channels

EMBO Reports
Transient receptor potential vanilloid (TRPV) channels play a critical role in calcium homeostasis, pain sensation, immunological response, and cancer progression. TRPV channels are blocked by ruthenium red (RR), a universal pore blocker for a wide array
Ruth A Pumroy, José J De Jesús-Pérez, Anna D Protopopova, Julia A Rocereta, Edwin C Fluck, Tabea Fricke, Bo-Hyun Lee, Tibor Rohacs, Andreas Leffler, Vera Moiseenkova-Bell   +9 more
doaj   +3 more sources

A co-operative knock-on mechanism underpins Ca ²⁺ -selective cation permeation in TRPV channels [PDF]

Journal of General Physiology, 2022
The selective exchange of ions across cellular membranes is a vital biological process. Ca 2+ -mediated signalling is implicated in a broad array of physiological processes in cells, whilst elevated intracellular concentrations of Ca 2+ are cytotoxic.
Callum M. Ives, Neil J. Thomson, Ulrich Zachariae   +2 more
core   +6 more sources

A novel ion channel formed by interaction of TRPML3 with TRPV5. [PDF]

PLoS ONE, 2013
TRPML3 and TRPV5 are members of the mucolipin (TRPML) and TRPV subfamilies of transient receptor potential (TRP) cation channels. Based on sequence similarities of the pore forming regions and on structure-function evidence, we hypothesized that the pore
Zhaohua Guo, Christian Grimm, Lars Becker, Anthony J Ricci, Stefan Heller   +4 more
doaj   +3 more sources

Differential Effects of TRPA and TRPV Channels on Behaviors of

Journal of Experimental Neuroscience, 2016
TRPA and TRPV ion channels are members of the transient receptor potential (TRP) cation channel superfamily, which mediates various sensory transductions.
Jennifer Thies, Vanessa Neutzler, Fidelma O'leary, He Liu   +3 more
doaj   +2 more sources

Human mutations highlight an intersubunit cation–π bond that stabilizes the closed but not open or inactivated states of TRPV channels [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Transient receptor potential (TRP) channels are key cation channels that respond to thermal, chemical, electric, or mechanical stimuli. There are >60 mutations known in TrpV4 that cause defects in bone or neural development.
Paul Blount, Andriy Anishkin, Jinfeng Teng   +2 more
exaly   +3 more sources

Transient receptor potential channels in Flaviviridae infection: A comprehensive review [PDF]

Channels
Diseases caused by Flaviviridae viruses exert profound global health and economic burdens due to their high incidence and associated mortality. Infection by the Flaviviridae family often leads to severe acute or chronic illnesses, including hemorrhagic ...
Fuchun Jiang, Xiaoqiang Yao, Chang-Bo Zheng   +2 more
doaj   +2 more sources

Role of transient receptor potential (TRP) channels in osteoarthritis: a comprehensive review [PDF]

Frontiers in Pharmacology
Osteoarthritis (OA) is a chronic degenerative joint disease, primarily characterized by the degeneration of articular cartilage, synovial inflammation, and persistent pain, which severely impairs the quality of life for hundreds of millions of patients ...
Pengyan Qiao, Wei Wang, Sumiao Liu, Yanli Yang, Pingzhi Wang, Yang Liu, Yazhen Su, Peng Hu, Jie Pan, Liyun Zhang   +9 more
doaj   +2 more sources

BRET-Based Approaches for Ion Channels: Emerging Applications and Future Directions. [PDF]

Arch Pharm (Weinheim)
Bioluminescence resonance energy transfer (BRET) is a versatile method for studying ligand–protein interactions. Its compatibility with high‐throughput screening and real‐time kinetics has made it widely used in drug discovery. Here, we summarize recent applications of BRET‐based methods for studying ligand binding to ion channels, highlighting key ...
Kock N, Heitzer L, Massa J, Taterra M, Bermúdez M, Koch O, Schiedel M.   +6 more
europepmc   +2 more sources

A REVIEW ON ROLE OF TRPV CATION CHANNELS

Journal of Biomedical and Pharmaceutical Research, 2021
The mammalian branch of the Transient Receptor Potential (TRP) superfamily of cation channels consists of 28 members. They can be subdivided in six main subfamilies: the TRPC (‘Canonical’), TRPV (‘Vanilloid’), TRPM (‘Melastatin’), TRPP (‘Polycystin’), TRPML (‘Mucolipin’) and the TRPA (‘Ankyrin’) group.
Deep Sharma, Rekha Rana, Kiran Thakur
openaire   +2 more sources

Transient Receptor Potential Vanilloid Subtype 1: Potential Role in Infection, Susceptibility, Symptoms and Treatment of COVID-19

Frontiers in Medicine, 2021
The battle against the new coronavirus that continues to kill millions of people will be still long. Novel strategies are demanded to control infection, mitigate symptoms and treatment of COVID-19. This is even more imperative given the long sequels that
Filippo Liviero, Manuela Campisi, Paola Mason, Sofia Pavanello   +3 more
doaj   +1 more source