Results 11 to 20 of about 6,526 (131)
A co-operative knock-on mechanism underpins Ca 2+ -selective cation permeation in TRPV channels
Journal of General Physiology, 2022 The selective exchange of ions across cellular membranes is a vital biological process. Ca 2+ -mediated signalling is implicated in a broad array of physiological processes in cells, whilst elevated intracellular concentrations of Ca 2+ are cytotoxic.
Callum M. Ives +2 more
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A REVIEW ON ROLE OF TRPV CATION CHANNELS
Journal of Biomedical and Pharmaceutical Research, 2021 The mammalian branch of the Transient Receptor Potential (TRP) superfamily of cation channels consists of 28 members. They can be subdivided in six main subfamilies: the TRPC (‘Canonical’), TRPV (‘Vanilloid’), TRPM (‘Melastatin’), TRPP (‘Polycystin’), TRPML (‘Mucolipin’) and the TRPA (‘Ankyrin’) group.
Deep Sharma, Rekha Rana, Kiran Thakur
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A novel ion channel formed by interaction of TRPML3 with TRPV5. [PDF]
PLoS ONE, 2013 TRPML3 and TRPV5 are members of the mucolipin (TRPML) and TRPV subfamilies of transient receptor potential (TRP) cation channels. Based on sequence similarities of the pore forming regions and on structure-function evidence, we hypothesized that the pore
Zhaohua Guo +4 more
doaj +1 more source
Vascular Dysfunction in Diabetes and Obesity: Focus on TRP Channels
Frontiers in Physiology, 2021 Transient receptor potential (TRP) superfamily consists of a diverse group of non-selective cation channels that has a wide tissue distribution and is involved in many physiological processes including sensory perception, secretion of hormones ...
Raiana dos Anjos Moraes +4 more
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Nicotinamide is an endogenous agonist for a C. elegans TRPV OSM-9 and OCR-4 channel
Nature Communications, 2016 TRPV are cation channels activated by physical and chemical stimuli. Here the authors show that nicotinamide is a soluble, endogenous agonist for orthologous TRPV channels fromC.
Awani Upadhyay +10 more
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Neonatal Bladder Irritation Is Associated With Vanilloid Receptor TRPV1 Expression in Adult Rats [PDF]
International Neurourology Journal, 2018 Purpose To evaluate whether mild chemical irritation of the bladder in neonatal rats is associated with persistent vanilloid receptor transient receptor potential vanilloid subfamily 1 (TRPV1) activity in adult rats.
Jee Soo Park +4 more
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The FASEB Journal, 2013 Study objective Ca 2+ entry via TRPV4 has been implicated in stretch‐induced barrier failure in isolated lungs. Here, we assessed the relevance of TRPV4 in VILI in vivo , and probed for the contribution
Laura Michalick +3 more
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Differential Effects of TRPA and TRPV Channels on Behaviors of
Journal of Experimental Neuroscience, 2016 TRPA and TRPV ion channels are members of the transient receptor potential (TRP) cation channel superfamily, which mediates various sensory transductions.
Jennifer Thies +3 more
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Structure of the full-length TRPV2 channel by cryo-EM
Nature Communications, 2016 Transient receptor potential (TRP) proteins are Ca2+-permeable cation channels activated by a range of chemical and physical stimuli. Here the authors describe a cryo-EM structure of the full-length TRPV2 channel that provides insight into the regulation
Kevin W. Huynh +6 more
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TRP Channels in Angiogenesis and Other Endothelial Functions
Frontiers in Physiology, 2018 Angiogenesis is the growth of blood vessels mediated by proliferation, migration, and spatial organization of endothelial cells. This mechanism is regulated by a balance between stimulatory and inhibitory factors.
Tarik Smani +7 more
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