Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK [PDF]
Cell Metabolism, 2019 Fructose-1,6-bisphosphate (FBP) aldolase links sensing of declining glucose availability to AMPK activation via the lysosomal pathway. However, how aldolase transmits lack of occupancy by FBP to AMPK activation remains unclear.
Changchuan Xie +34 more
core +7 more sources
Nicotinamide is an endogenous agonist for a C. elegans TRPV OSM-9 and OCR-4 channel
Nature Communications, 2016 TRPV are cation channels activated by physical and chemical stimuli. Here the authors show that nicotinamide is a soluble, endogenous agonist for orthologous TRPV channels fromC.
Awani Upadhyay +10 more
doaj +2 more sources
Molecular details of ruthenium red pore block in TRPV channels
EMBO ReportsTransient receptor potential vanilloid (TRPV) channels play a critical role in calcium homeostasis, pain sensation, immunological response, and cancer progression. TRPV channels are blocked by ruthenium red (RR), a universal pore blocker for a wide array
Ruth A Pumroy +9 more
doaj +2 more sources
Evidence for Novel Pharmacological Sensitivities of Transient Receptor Potential (TRP) Channels in Schistosoma mansoni. [PDF]
PLoS Neglected Tropical Diseases, 2015 Schistosomiasis, caused by parasitic flatworms of the genus Schistosoma, is a neglected tropical disease affecting hundreds of millions globally. Praziquantel (PZQ), the only drug currently available for treatment and control, is largely ineffective ...
Swarna Bais +3 more
doaj +1 more source
TRP Channels in Cancer: Signaling Mechanisms and Translational Approaches
Biomolecules, 2023 Ion channels play a crucial role in a wide range of biological processes, including cell cycle regulation and cancer progression. In particular, the transient receptor potential (TRP) family of channels has emerged as a promising therapeutic target due ...
Matilde Marini +5 more
doaj +1 more source
Diagnostics, 2021 Spontaneous swallowing contributes to airway protection and depends on the activation of brainstem reflex circuits in the central pattern generator (CPG).
Weslania Nascimento +6 more
doaj +1 more source
TRPV4-A Missing Link Between Mechanosensation and Immunity [PDF]
, 2020 Transient receptor potential vanilloid-type 4 (TRPV4) cation channel is widely expressed in all tissues as well as in immune cells and its function as mechanosensitive Ca2+ channel seems to be conserved throughout all mammalian species. Of late, emerging
Kuebler, Wolfgang M., Michalick, Laura
core +1 more source
Atypical pharmacology of schistosome TRPA1-like ion channels. [PDF]
PLoS Neglected Tropical Diseases, 2018 Parasitic flatworms of the genus Schistosoma cause schistosomiasis, a neglected tropical disease estimated to affect over 200 million people worldwide.
Swarna Bais +5 more
doaj +1 more source
Vascular Dysfunction in Diabetes and Obesity: Focus on TRP Channels
Frontiers in Physiology, 2021 Transient receptor potential (TRP) superfamily consists of a diverse group of non-selective cation channels that has a wide tissue distribution and is involved in many physiological processes including sensory perception, secretion of hormones ...
Raiana dos Anjos Moraes +4 more
doaj +1 more source
Neonatal Bladder Irritation Is Associated With Vanilloid Receptor TRPV1 Expression in Adult Rats [PDF]
International Neurourology Journal, 2018 Purpose To evaluate whether mild chemical irritation of the bladder in neonatal rats is associated with persistent vanilloid receptor transient receptor potential vanilloid subfamily 1 (TRPV1) activity in adult rats.
Jee Soo Park +4 more
doaj +1 more source