Discovery and pharmacological characterization of a novel potent inhibitor of diacylglycerol-sensitive TRPC cation channels. [PDF]
Br J Pharmacol, 2015 Background and PurposeThe cation channel transient receptor potential canonical (TRPC) 6 has been associated with several pathologies including focal segmental glomerulosclerosis, pulmonary hypertension and ischaemia reperfusion‐induced lung oedema. We set out to discover novel inhibitors ofTRPC6channels and investigate the therapeutic potential of ...
Maier T +13 more
europepmc +4 more sources
Remarkable Progress with Small-Molecule Modulation of TRPC1/4/5 Channels: Implications for Understanding the Channels in Health and Disease [PDF]
Cells, 2018 Proteins of the TRPC family can form many homo- and heterotetrameric cation channels permeable to Na+, K+ and Ca2+. In this review, we focus on channels formed by the isoforms TRPC1, TRPC4 and TRPC5.
Aisling Minard +6 more
doaj +4 more sources
TRPC3 and TRPC6: Multimodal Cation-Conducting Channels Regulating Cardiovascular Contractility and Remodeling [PDF]
CellsTransient receptor potential canonical (TRPC) channels function as multimodal cation channels that integrate chemical and mechanical cues to regulate cellular signaling.
Takuro Numaga-Tomita, Motohiro Nishida
doaj +2 more sources
Role of transient receptor potential (TRP) channels in osteoarthritis: a comprehensive review [PDF]
Frontiers in PharmacologyOsteoarthritis (OA) is a chronic degenerative joint disease, primarily characterized by the degeneration of articular cartilage, synovial inflammation, and persistent pain, which severely impairs the quality of life for hundreds of millions of patients ...
Pengyan Qiao +9 more
doaj +2 more sources
Effects of TRPC1’s Lysines on Heteromeric TRPC5-TRPC1 Channel Function [PDF]
CellsBackground: TRPC5 proteins form plasma membrane cation channels and are expressed in the nervous and cardiovascular systems. TRPC5 activation leads to cell depolarization and increases neuronal excitability, whereas a homologous TRPC1 inhibits TRPC5 ...
Isaac S. Demaree +5 more
doaj +2 more sources
Research progress on the role of canonical transient receptor potential channels in skeletal muscle diseases [PDF]
Jichu yixue yu linchuang, 2023 Canonical transient receptor potential(TRPC) is a kind of non-selective cation channel located in the cell membrane, which plays an important role in electrophysiological activity of cells.
XIE Dongge, LI Junhao, HAN Han, LI Shoutian
doaj +1 more source
Transient receptor potential canonical type 3 channels control the vascular contractility of mouse mesenteric arteries [PDF]
, 2014 Transient receptor potential canonical type 3 (TRPC3) channels are non-selective cation channels and regulate intracellular Ca2+ concentration. We examined the role of TRPC3 channels in agonist-, membrane depolarization (high K+)-, and mechanical ...
Abramowitz, Joel +6 more
core +13 more sources
Frontiers in Cell and Developmental Biology, 2021 The seven canonical members of transient receptor potential (TRPC) proteins form cation channels that evoke membrane depolarization and intracellular calcium concentration ([Ca2+]i) rise, which are not only important for regulating cell function but ...
Jaepyo Jeon +12 more
doaj +1 more source
Inhibition of diacylglycerol-sensitive TRPC channels by synthetic and natural steroids. [PDF]
PLoS ONE, 2012 TRPC channels are a family of nonselective cation channels that regulate ion homeostasis and intracellular Ca(2+) signaling in numerous cell types. Important physiological functions such as vasoregulation, neuronal growth, and pheromone recognition have ...
Susanne Miehe +8 more
doaj +1 more source
TRPC1/5-CaV3 Complex Mediates Leptin-Induced Excitability in Hypothalamic Neurons
Frontiers in Neuroscience, 2021 Leptin regulates hypothalamic POMC+ (pro-opiomelanocortin) neurons by inducing TRPC (Transient Receptor Potential Cation) channel-mediate membrane depolarization.
Paula P. Perissinotti +2 more
doaj +1 more source