Results 1 to 10 of about 4,753 (136)

Discovery and pharmacological characterization of a novel potent inhibitor of diacylglycerol-sensitive TRPC cation channels. [PDF]

Br J Pharmacol, 2015
Background and PurposeThe cation channel transient receptor potential canonical (TRPC) 6 has been associated with several pathologies including focal segmental glomerulosclerosis, pulmonary hypertension and ischaemia reperfusion‐induced lung oedema. We set out to discover novel inhibitors ofTRPC6channels and investigate the therapeutic potential of ...
Maier T, Follmann M, Hessler G, Kleemann HW, Hachtel S, Fuchs B, Weissmann N, Linz W, Schmidt T, Löhn M, Schroeter K, Wang L, Rütten H, Strübing C.   +13 more
europepmc   +4 more sources

Transient Receptor Potential Canonical (TRPC) Channels: Then and Now

Cells, 2020
Twenty-five years ago, the first mammalian Transient Receptor Potential Canonical (TRPC) channel was cloned, opening the vast horizon of the TRPC field. Today, we know that there are seven TRPC channels (TRPC1–7).
Xingjuan Chen, Gagandeep Sooch, Isaac S. Demaree, Fletcher A. White, Alexander G. Obukhov   +4 more
doaj   +3 more sources

The mammalian TRPC cation channels

Biochimica Et Biophysica Acta - Molecular Cell Research, 2004
Transient Receptor Potential-Canonical (TRPC) channels are mammalian homologs of Transient Receptor Potential (TRP), a Ca(2+)-permeable channel involved in the phospholipase C-regulated photoreceptor activation mechanism in Drosophila. The seven mammalian TRPCs constitute a family of channels which have been proposed to function as store-operated as ...
Mohamed Trebak, James Putney, Guillermo Vazquez   +2 more
exaly   +3 more sources

Inhibition of diacylglycerol-sensitive TRPC channels by synthetic and natural steroids. [PDF]

PLoS ONE, 2012
TRPC channels are a family of nonselective cation channels that regulate ion homeostasis and intracellular Ca(2+) signaling in numerous cell types. Important physiological functions such as vasoregulation, neuronal growth, and pheromone recognition have ...
Susanne Miehe, Peter Crause, Thorsten Schmidt, Matthias Löhn, Heinz-Werner Kleemann, Thomas Licher, Werner Dittrich, Hartmut Rütten, Carsten Strübing   +8 more
doaj   +3 more sources

Bicarbonate-Triggered In Vitro Capacitation of Boar Spermatozoa Conveys an Increased Relative Abundance of the Canonical Transient Receptor Potential Cation (TRPC) Channels 3, 4, 6 and 7 and of CatSper-γ Subunit mRNA Transcripts

Animals, 2022
Sperm capacitation is a stepwise complex biochemical process towards fertilization. It includes a crucial early calcium (Ca2+) transport mediated by CatSper channels and Canonical Transient Potential Channels (TRPC). We studied the relative abundance of mRNA transcripts changes of the CatSper β, γ and δ subunits and TRPC-channels 1, 3, 4, 6 and 7 in ...
Cristina A Martinez, Manuel Hidalgo, Jesus Dorado   +2 more
exaly   +9 more sources

TRPC3 and TRPC6: Multimodal Cation-Conducting Channels Regulating Cardiovascular Contractility and Remodeling [PDF]

Cells
Transient receptor potential canonical (TRPC) channels function as multimodal cation channels that integrate chemical and mechanical cues to regulate cellular signaling.
Takuro Numaga-Tomita, Motohiro Nishida
doaj   +2 more sources

Role of transient receptor potential (TRP) channels in osteoarthritis: a comprehensive review [PDF]

Frontiers in Pharmacology
Osteoarthritis (OA) is a chronic degenerative joint disease, primarily characterized by the degeneration of articular cartilage, synovial inflammation, and persistent pain, which severely impairs the quality of life for hundreds of millions of patients ...
Pengyan Qiao, Wei Wang, Sumiao Liu, Yanli Yang, Pingzhi Wang, Yang Liu, Yazhen Su, Peng Hu, Jie Pan, Liyun Zhang   +9 more
doaj   +2 more sources

Effects of TRPC1’s Lysines on Heteromeric TRPC5-TRPC1 Channel Function [PDF]

Cells
Background: TRPC5 proteins form plasma membrane cation channels and are expressed in the nervous and cardiovascular systems. TRPC5 activation leads to cell depolarization and increases neuronal excitability, whereas a homologous TRPC1 inhibits TRPC5 ...
Isaac S. Demaree, Sanjay Kumar, Kayla Tennessen, Quyen Q. Hoang, Fletcher A. White, Alexander G. Obukhov   +5 more
doaj   +2 more sources

Research progress on the role of canonical transient receptor potential channels in skeletal muscle diseases [PDF]

Jichu yixue yu linchuang, 2023
Canonical transient receptor potential(TRPC) is a kind of non-selective cation channel located in the cell membrane, which plays an important role in electrophysiological activity of cells.
XIE Dongge, LI Junhao, HAN Han, LI Shoutian
doaj   +1 more source

Contribution of TRPC Channels in Neuronal Excitotoxicity Associated With Neurodegenerative Disease and Ischemic Stroke

Frontiers in Cell and Developmental Biology, 2021
The seven canonical members of transient receptor potential (TRPC) proteins form cation channels that evoke membrane depolarization and intracellular calcium concentration ([Ca2+]i) rise, which are not only important for regulating cell function but ...
Jaepyo Jeon, Fan Bu, Guanghua Sun, Jin-Bin Tian, Shun-Ming Ting, Jun Li, Jaroslaw Aronowski, Lutz Birnbaumer, Lutz Birnbaumer, Lutz Birnbaumer, Marc Freichel, Marc Freichel, Michael X. Zhu   +12 more
doaj   +1 more source