Results 21 to 30 of about 4,772 (153)
Rat hypocretin/orexin neurons are maintained in a depolarized state by TRPC channels. [PDF]
PLoS ONE, 2010 In a previous study we proposed that the depolarized state of the wake-promoting hypocretin/orexin (hcrt/orx) neurons was independent of synaptic inputs as it persisted in tetrodotoxin and low calcium/high magnesium solutions.
Vesna Cvetkovic-Lopes +7 more
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TRPC Channels in the SOCE Scenario
Cells, 2020 Transient receptor potential (TRP) proteins form non-selective Ca2+ permeable channels that contribute to the modulation of a number of physiological functions in a variety of cell types. Since the identification of TRP proteins in Drosophila, it is well
Jose J. Lopez +5 more
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Cells, 2020 The cation channel subunit TRPC1 is strongly expressed in central neurons including neurons in the CA1 region of the hippocampus where it forms complexes with TRPC4 and TRPC5.
Frauke Kepura +3 more
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Pacemaking in the heart: a redundant and robust system of mutually entrained oscillators driving cardiac automaticity. [PDF]
J PhysiolAbstract figure legend Cardiac pacemaking: the redundant and robust organ‐to‐subcellular system driving the spontaneous electrical activity responsible for regular, rhythmic excitation of the heart. Abstract The heart is an electrically controlled, mechanical pump that provides a constant supply of blood to the body.
MacDonald EA, Quinn TA.
europepmc +2 more sources
Angiotensin-II-Evoked Ca2+ Entry in Murine Cardiac Fibroblasts Does Not Depend on TRPC Channels
Cells, 2020 TRPC proteins form cation conducting channels regulated by different stimuli and are regulators of the cellular calcium homeostasis. TRPC are expressed in cardiac cells including cardiac fibroblasts (CFs) and have been implicated in the development of ...
Juan E. Camacho Londoño +8 more
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Leptin-Induced Endothelium-Independent Vasoconstriction in Thoracic Aorta and Pulmonary Artery of Spontaneously Hypertensive Rats: Role of Calcium Channels and Stores. [PDF]
PLoS ONE, 2017 Decreased leptin-induced endothelium-dependent vasodilation has been reported in spontaneously hypertensive rats (SHR). Here, we report leptin-induced vasoconstriction in endothelium-denuded pulmonary artery and thoracic aorta from SHR and sought to ...
Samantha Gomart +10 more
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TRPC Channels in Cardiac Plasticity
Cells, 2020 The heart flexibly changes its structure in response to changing environments and oxygen/nutrition demands of the body. Increased and decreased mechanical loading induces hypertrophy and atrophy of cardiomyocytes, respectively.
Takuro Numaga-Tomita, Motohiro Nishida
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Frontiers in Pharmacology, 2015 Transient receptor potential canonical (TRPC) channels are Ca2+-permeable, nonselective cation channels that carry receptor-operated Ca2+ currents (ROCs) triggered by receptor-induced, phospholipase C (PLC)-catalyzed hydrolysis of phosphatidylinositol 4 ...
Masayuki X Mori +6 more
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Cells, 2019 The study of the structure−function relationship of ion channels has been one of the most challenging goals in contemporary physiology. Revelation of the three-dimensional (3D) structure of ion channels has facilitated our understanding of many of ...
Jinsung Kim +3 more
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Frontiers in Neuroscience, 2021 We investigated the contribution of excitatory transient receptor potential canonical (TRPC) cation channels to posttraumatic hyperexcitability in the brain 7 days following controlled cortical impact model of traumatic brain injury (TBI) to the parietal
Chase M. Carver +3 more
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