Results 1 to 10 of about 18,800 (265)

TRPC Channels in Cardiac Plasticity [PDF]

Cells, 2020
The heart flexibly changes its structure in response to changing environments and oxygen/nutrition demands of the body. Increased and decreased mechanical loading induces hypertrophy and atrophy of cardiomyocytes, respectively.
Motohiro Nishida
exaly   +5 more sources

TRPC Channels in the SOCE Scenario

Cells, 2020
Transient receptor potential (TRP) proteins form non-selective Ca2+ permeable channels that contribute to the modulation of a number of physiological functions in a variety of cell types. Since the identification of TRP proteins in Drosophila, it is well
Jose J. Lopez, Isaac Jardin, Jose Sanchez-Collado, Ginés M. Salido, Tarik Smani, Juan A. Rosado   +5 more
doaj   +8 more sources

Structure–Function Relationship and Physiological Roles of Transient Receptor Potential Canonical (TRPC) 4 and 5 Channels [PDF]

Cells, 2019
The study of the structure−function relationship of ion channels has been one of the most challenging goals in contemporary physiology. Revelation of the three-dimensional (3D) structure of ion channels has facilitated our understanding of many of ...
Jinsung Kim, Juyeon Ko, Chansik Hong, Insuk So   +3 more
doaj   +2 more sources

Transient Receptor Potential Canonical (TRPC) Channels: Then and Now

Cells, 2020
Twenty-five years ago, the first mammalian Transient Receptor Potential Canonical (TRPC) channel was cloned, opening the vast horizon of the TRPC field. Today, we know that there are seven TRPC channels (TRPC1–7).
Xingjuan Chen, Fletcher A White, Alexander G Obukhov   +2 more
exaly   +3 more sources

TRPC channels contribute to endothelial dysfunction in pulmonary arterial hypertension [PDF]

Respiratory Research
Background- Pulmonary arterial hypertension (PAH) is a rare, fatal, and progressive pulmonary vascular disease. Pulmonary endothelial cell dysfunction is a hallmark of PAH, defined by excessive proliferation and dysregulated angiogenesis, along with ...
Anaïs Saint-Martin Willer, Bastien Masson, Loann Laubry, Mary Dutheil, Kristelle El Jekmek, Gilles Carpentier, Mathieu Gourmelon, Jessica Sabourin, Marc Humbert, Olaf Mercier, Grégoire Ruffenach, David Montani, Véronique Capuano, Fabrice Antigny   +13 more
doaj   +2 more sources

TRPC Channels as Mediators of Hypoxia-Induced Pulmonary Hypertension in Obstructive Sleep Apnea [PDF]

Int J Mol Sci
Torres Y, Aristizábal-Pachón A, Otero L.   +2 more
europepmc   +3 more sources

TRPC proteins contribute to development of diabetic retinopathy and regulate glyoxalase 1 activity and methylglyoxal accumulation

Molecular Metabolism, 2018
Andrea Schlotterer, Rebekka Medert, Peter P Nawroth   +2 more
exaly   +2 more sources

TRPC1 channel clustering during store-operated Ca2+ entry in keratinocytes

Frontiers in Physiology, 2023
Skin is the largest organ in the human body with ∼95% of its surface made up of keratinocytes. These cells maintain a healthy skin barrier through regulated differentiation driven by Ca2+-transcriptional coupling.
Declan Manning, Richard Barrett-Jolley, Richard L. Evans, Caroline Dart   +3 more
doaj   +1 more source

Effect of SKF96365 on Myocardial Fibrosis in Type-II Diabetic Rats

Frontiers in Bioscience-Landmark, 2023
Background: Diabetes mellitus type 2 is a risk factor for developing heart failure and myocardial fibrosis, but there is no specific therapy for diabetic heart disease.
Huan-zhi Liu, Wei Wu
doaj   +1 more source

Research progress on the role of canonical transient receptor potential channels in skeletal muscle diseases [PDF]

Jichu yixue yu linchuang, 2023
Canonical transient receptor potential(TRPC) is a kind of non-selective cation channel located in the cell membrane, which plays an important role in electrophysiological activity of cells.
XIE Dongge, LI Junhao, HAN Han, LI Shoutian
doaj   +1 more source