Results 1 to 10 of about 9,890 (134)
Transient receptor potential canonical (TRPC) channels in diabetes and associated complications [PDF]
ChannelsTRPC channels are widely expressed in various tissues and cell types, and accumulating evidence indicates that they play critical roles in pancreatic β cell function, including the regulation of insulin secretion.
Yi Wu, Shengming Chen, Xiaolu Xia
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Transient Receptor Potential Canonical (TRPC) Channels: Then and Now
Cells, 2020 Twenty-five years ago, the first mammalian Transient Receptor Potential Canonical (TRPC) channel was cloned, opening the vast horizon of the TRPC field. Today, we know that there are seven TRPC channels (TRPC1–7).
Alexander G Obukhov +2 more
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TRPC channels contribute to endothelial dysfunction in pulmonary arterial hypertension [PDF]
Respiratory ResearchBackground- Pulmonary arterial hypertension (PAH) is a rare, fatal, and progressive pulmonary vascular disease. Pulmonary endothelial cell dysfunction is a hallmark of PAH, defined by excessive proliferation and dysregulated angiogenesis, along with ...
Anaïs Saint-Martin Willer +13 more
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TRPC Channels in Cardiac Plasticity
Cells, 2020 The heart flexibly changes its structure in response to changing environments and oxygen/nutrition demands of the body. Increased and decreased mechanical loading induces hypertrophy and atrophy of cardiomyocytes, respectively.
Motohiro Nishida +2 more
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TRPC1 channel clustering during store-operated Ca2+ entry in keratinocytes
Frontiers in Physiology, 2023 Skin is the largest organ in the human body with ∼95% of its surface made up of keratinocytes. These cells maintain a healthy skin barrier through regulated differentiation driven by Ca2+-transcriptional coupling.
Declan Manning +3 more
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Effect of SKF96365 on Myocardial Fibrosis in Type-II Diabetic Rats
Frontiers in Bioscience-Landmark, 2023 Background: Diabetes mellitus type 2 is a risk factor for developing heart failure and myocardial fibrosis, but there is no specific therapy for diabetic heart disease.
Huan-zhi Liu, Wei Wu
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Frontiers in Cell and Developmental Biology, 2021 The seven canonical members of transient receptor potential (TRPC) proteins form cation channels that evoke membrane depolarization and intracellular calcium concentration ([Ca2+]i) rise, which are not only important for regulating cell function but ...
Jaepyo Jeon +12 more
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Research progress on the role of canonical transient receptor potential channels in skeletal muscle diseases [PDF]
Jichu yixue yu linchuang, 2023 Canonical transient receptor potential(TRPC) is a kind of non-selective cation channel located in the cell membrane, which plays an important role in electrophysiological activity of cells.
XIE Dongge, LI Junhao, HAN Han, LI Shoutian
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Role of Transient Receptor Potential Canonical Channels in Heart Physiology and Pathophysiology
Frontiers in Cardiovascular Medicine, 2020 Transient receptor potential canonical (TRPC) channels are involved in the regulation of cardiac function under (patho)physiological conditions and are closely associated with the pathogenesis of cardiac hypertrophy, arrhythmias, and myocardial ...
Hairuo Wen +3 more
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Transient Receptor Potential Canonical Channels in Health and Disease: A 2020 Update
Cells, 2021 This 2020 Special Issue “TRPC channels” of Cells was dedicated to commemorating the 25th anniversary of discovery of the Transient Receptor Potential Canonical (TRPC) channel subfamily [...]
Priya R. Kirtley +3 more
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