Transient receptor potential canonical (TRPC) channels in diabetes and associated complications [PDF]
ChannelsTRPC channels are widely expressed in various tissues and cell types, and accumulating evidence indicates that they play critical roles in pancreatic β cell function, including the regulation of insulin secretion.
Yi Wu, Shengming Chen, Xiaolu Xia
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TRPC Channels in Cardiac Plasticity
Cells, 2020 The heart flexibly changes its structure in response to changing environments and oxygen/nutrition demands of the body. Increased and decreased mechanical loading induces hypertrophy and atrophy of cardiomyocytes, respectively.
Takuro Numaga-Tomita, Motohiro Nishida
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Diethylcarbamazine elicits calcium signals by activation of Brugia malayi TRP-2b channels heterologously expressed in HEK293 cells [PDF]
Scientific ReportsDiethylcarbamazine is a classic anthelmintic that is used for the prevention and treatment of lymphatic filariasis. The mode of action of diethylcarbamazine is still not well understood with the consensus that it acts on the host immune system, rather ...
Paul D. E. Williams +3 more
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Research progress on the role of canonical transient receptor potential channels in skeletal muscle diseases [PDF]
Jichu yixue yu linchuang, 2023 Canonical transient receptor potential(TRPC) is a kind of non-selective cation channel located in the cell membrane, which plays an important role in electrophysiological activity of cells.
XIE Dongge, LI Junhao, HAN Han, LI Shoutian
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TRPC1 channel clustering during store-operated Ca2+ entry in keratinocytes
Frontiers in Physiology, 2023 Skin is the largest organ in the human body with ∼95% of its surface made up of keratinocytes. These cells maintain a healthy skin barrier through regulated differentiation driven by Ca2+-transcriptional coupling.
Declan Manning +3 more
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Transient Receptor Potential Canonical Channels in Health and Disease: A 2020 Update
Cells, 2021 This 2020 Special Issue “TRPC channels” of Cells was dedicated to commemorating the 25th anniversary of discovery of the Transient Receptor Potential Canonical (TRPC) channel subfamily [...]
Priya R. Kirtley +3 more
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Inhibition of diacylglycerol-sensitive TRPC channels by synthetic and natural steroids. [PDF]
PLoS ONE, 2012 TRPC channels are a family of nonselective cation channels that regulate ion homeostasis and intracellular Ca(2+) signaling in numerous cell types. Important physiological functions such as vasoregulation, neuronal growth, and pheromone recognition have ...
Susanne Miehe +8 more
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TRPC1/5-CaV3 Complex Mediates Leptin-Induced Excitability in Hypothalamic Neurons
Frontiers in Neuroscience, 2021 Leptin regulates hypothalamic POMC+ (pro-opiomelanocortin) neurons by inducing TRPC (Transient Receptor Potential Cation) channel-mediate membrane depolarization.
Paula P. Perissinotti +2 more
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Ca2+ Influx through TRPC Channels Is Regulated by Homocysteine–Copper Complexes
Biomolecules, 2023 An elevated level of circulating homocysteine (Hcy) has been regarded as an independent risk factor for cardiovascular disease; however, the clinical benefit of Hcy lowering-therapy is not satisfying.
Gui-Lan Chen +6 more
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TRPC Channels: Dysregulation and Ca2+ Mishandling in Ischemic Heart Disease
Cells, 2020 Transient receptor potential canonical (TRPC) channels are ubiquitously expressed in excitable and non-excitable cardiac cells where they sense and respond to a wide variety of physical and chemical stimuli.
Débora Falcón +7 more
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