Results 1 to 10 of about 1,209,942 (198)

TRPC Channels in Cardiac Plasticity [PDF]

Cells, 2020
The heart flexibly changes its structure in response to changing environments and oxygen/nutrition demands of the body. Increased and decreased mechanical loading induces hypertrophy and atrophy of cardiomyocytes, respectively.
Takuro Numaga-Tomita, Motohiro Nishida
doaj   +6 more sources

The mammalian TRPC cation channels [PDF]

Biochimica Et Biophysica Acta - Molecular Cell Research, 2004
Transient Receptor Potential-Canonical (TRPC) channels are mammalian homologs of Transient Receptor Potential (TRP), a Ca(2+)-permeable channel involved in the phospholipase C-regulated photoreceptor activation mechanism in Drosophila. The seven mammalian TRPCs constitute a family of channels which have been proposed to function as store-operated as ...
Mohamed Trebak, James Putney, Guillermo Vazquez   +2 more
exaly   +4 more sources

TRPC Channels in the SOCE Scenario [PDF]

Cells, 2020
Transient receptor potential (TRP) proteins form non-selective Ca2+ permeable channels that contribute to the modulation of a number of physiological functions in a variety of cell types. Since the identification of TRP proteins in Drosophila, it is well
Jose J. Lopez, Isaac Jardin, Jose Sanchez-Collado, Ginés M. Salido, Tarik Smani, Juan A. Rosado   +5 more
doaj   +8 more sources

TRPC Channels in Proteinuric Kidney Diseases [PDF]

Cells, 2019
Over a decade ago, mutations in the gene encoding TRPC6 (transient receptor potential cation channel, subfamily C, member 6) were linked to development of familial forms of nephrosis. Since this discovery, TRPC6 has been implicated in the pathophysiology
Gentzon Hall, Liming Wang, Robert F. Spurney   +2 more
doaj   +4 more sources

Transient receptor potential canonical (TRPC) channels in diabetes and associated complications [PDF]

Channels
TRPC channels are widely expressed in various tissues and cell types, and accumulating evidence indicates that they play critical roles in pancreatic β cell function, including the regulation of insulin secretion.
Yi Wu, Shengming Chen, Xiaolu Xia
doaj   +2 more sources

TRPC3-Driven Calcium Microdomains Instruct Peripheral Nerve Regeneration With Protective Implications for Central Neurons. [PDF]

Adv Sci (Weinh)
How localized Ca2+ signals orchestrate neural repair remains unclear. Here, we show that TRPC3‐driven calcium microdomains direct nerve repair by coupling spatially confined Ca2+ signals to axon regeneration. This module operates in injured peripheral neurons and correlates with neuroprotection in Parkinson's disease, revealing a spatial logic for ...
Lu Y, Zhao J, Xie Z, Wang Y, Wang R, Wang B, Shen C, Chen Y, Yao J, Li Z, Xu H, Chai Z, Zhang Z, Wang C, Huang R.   +14 more
europepmc   +2 more sources

The potential of TRPC channel-mediated autophagy in myocardial ischemia-reperfusion injury [PDF]

Journal of Cardiothoracic Surgery
Background Myocardial ischemia/reperfusion injury (MI/RI) is a common complication in the treatment of acute myocardial infarction, which is often accompanied by high disability rate and mortality.Autophagy is a highly conserved cellular process widely ...
Han Han, Yanru Wang, Shoutian Li
doaj   +2 more sources

Drafting the calmodulation playbook: Emerging structural insights into transient receptor potential channel regulation by calmodulin. [PDF]

J Physiol
Abstract figure legend Calmodulin (CaM) is a ubiquitous calcium (Ca2+) sensor that translates intracellular Ca2+ signals into modulation of hundreds of effector proteins including ion channels. CaM is increasingly recognized as a key regulator of the transient receptor potential (TRP) channel family, yet the underlying ‘calmodulation playbook’ is only ...
Alemayhu AM, Paulsen CE.
europepmc   +2 more sources

Mechanism and functional significance of TRPC channel multimerization [PDF]

Seminars in Cell and Developmental Biology, 2006
Ca(2+) signaling regulates many important physiological events within a diverse set of living organisms. In particular, sustained Ca(2+) signals play an important role in controlling cell proliferation, cell differentiation and the activation of immune cells.
Mitchel L Villereal
exaly   +3 more sources

Pulmonary Hypertension Molecular Switch: HIF Signaling Pathway. [PDF]

Pulm Circ
ABSTRACT Pulmonary hypertension (PH) is a multifaceted disorder characterized by the crucial involvement of activated hypoxia‐inducible factors (HIFs). Recent investigations have unveiled HIFs' ability to orchestrate a wide array of signaling cascades, encompassing voltage‐gated potassium channels, non‐selective cation channels (NSCCs), Ca2+/PKC/MAPKs,
Sun Y, Ding R, Su X, Qin L, Wang L, Yi J, Hu R, You S, Tan Z, Dai A.   +9 more
europepmc   +2 more sources